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Robert Epple

Observed names: Epple, R., Epple, Robert, R. EPPLE, R. Epple
ORCID: 0000-0001-7157-806X
Observed ORCID: 0000-0001-7157-806X
OpenAlex ID: A5020078905
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
2016 · Yong Jia, Cai-Hong Yun, et al. · Nature · 926
Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks
2002 · Philippe Dupau, Robert Epple, et al. · Advanced Synthesis & Catalysis · 248
EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
2016 · Yong Jia, Jose Juarez, et al. · Cancer Research · 121
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A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins
2002 · Malin A. Andersson, Robert Epple, et al. · Angewandte Chemie International Edition · 119
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers
2016 · Gérald Lelais, Robert Epple, et al. · Journal of Medicinal Chemistry · 95
Investigation of Flavin-Containing DNA-Repair Model Compounds
1997 · Robert Epple, Ernst-Udo Wallenborn, et al. · Journal of the American Chemical Society · 72
Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3
2006 · David C. Tully, Hong Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 57
Repair of UV Light Induced DNA Lesions: A Comparative Study with Model Compounds
1998 · Thomas Carell, Robert Epple · European Journal of Organic Chemistry · 53
Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists
2009 · Robert Epple, Christopher Cow, et al. · Journal of Medicinal Chemistry · 48
Synthesis of Flavin‐Containing Model Compounds for DNA Photolyase Mediated DNA Repair
1996 · Thomas Carell, Robert Epple, et al. · Angewandte Chemie International Edition in English · 46
A Comparative Repair Study of Thymine- and Uracil-Photodimers with Model Compounds and a Photolyase Repair Enzyme
2000 · Jens Butenandt, Robert Epple, et al. · Chemistry - A European Journal · 40
1,3,5-Trisubstituted aryls as highly selective PPARδ agonists
2006 · Robert Epple, Mihai Azimioara, et al. · Bioorganic & Medicinal Chemistry Letters · 39
Solid-Phase Synthesis of Nucleoside Analogues
2003 · Robert Epple, Romas Kudirka, et al. · Journal of Combinatorial Chemistry · 36
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
2006 · David C. Tully, Hong Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 32
A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins
2002 · Malin A. Andersson, Robert Epple, et al. · Angewandte Chemie · 30
3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists. Part 2
2006 · Robert Epple, Mihai Azimioara, et al. · Bioorganic & Medicinal Chemistry Letters · 29
Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo
2018 · Juraj Velcicky, Ursula Bodendorf, et al. · Journal of Medicinal Chemistry · 28
Flavin- and Deazaflavin-Containing Model Compounds Mimic the Energy Transfer Step in Type-II DNA-Photolyases
1998 · Robert Epple, Thomas Carell · Angewandte Chemie International Edition · 28
Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma
2020 · Casey J. N. Mathison, Donatella Chianelli, et al. · ACS Medicinal Chemistry Letters · 26
3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1
2006 · Robert Epple, Ross Russo, et al. · Bioorganic & Medicinal Chemistry Letters · 24
Efficient Light-Dependent DNA Repair Requires a Large Cofactor Separation
1999 · Robert Epple, Thomas Carell · Journal of the American Chemical Society · 22
Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1
2005 · Hong Liu, David C. Tully, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Synthesis and structure of (carboxymethyl)‐functionalized cyclobuta‐fused uracil dimers
1997 · Thomas Carell, Robert Epple, et al. · Helvetica Chimica Acta · 18
新規PPARδ作動薬としての3,4,5‐三置換イソオキサゾール:1部
2006 · Robert Epple, Russo Ross, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S
2007 · Arnab K. Chatterjee, Hong Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 16
Works count: 61
Citation count: 2,279
H-index: 21
I10-index: 30
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