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Masakazu Kakuni

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice
2015 · Chise Tateno, Yosuke Kawase, et al. · PLoS ONE · 139
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In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice
2010 · Chihiro Yamasaki, Miho Kataoka, et al. · Drug Metabolism and Pharmacokinetics · 70
Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection
2015 · Naoki Yamamoto, Yusuke Sato, et al. · Journal of Hepatology · 67
Morphological and microarray analyses of human hepatocytes from xenogeneic host livers
2012 · Chise Tateno, Fuyuki Miya, et al. · Laboratory Investigation · 66
Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies
2013 · Masakazu Kakuni, Chihiro Yamasaki, et al. · International Journal of Molecular Sciences · 49
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Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
2011 · Maki Hasegawa, Harunobu Tahara, et al. · Drug Metabolism and Disposition · 47
Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury
2012 · Masakazu Kakuni, Mayu Morita, et al. · Toxicology Letters · 46
Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
2008 · Masako Uchii, Tadafumi Tamura, et al. · Arthritis Research & Therapy · 45
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Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism
2014 · Thomas J. Bateman, Vijay G.B. Reddy, et al. · Drug Metabolism and Disposition · 44
Organic Anion–Transporting Polypeptide (OATP)–Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized Liver
2017 · Masashi Uchida, Yoriko Tajima, et al. · Drug Metabolism and Disposition · 32
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Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV
2020 · Nobuyo Higashi-Kuwata, Sanae Hayashi, et al. · Journal of Hepatology · 30
Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model
2018 · Xin Ye, Chise Tateno, et al. · ACS Infectious Diseases · 27
Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of theIL28Bgene
2012 · Tsunamasa Watanabe, Fuminaka Sugauchi, et al. · Gut · 23
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Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5
2018 · Kaito Nihira, Ken-ichiro Nan-ya, et al. · Toxicological Sciences · 20
Protective effects of glutathione on 5-fluorouracil-induced myelosuppression in mice
2003 · Seiji Kojima, Katsumi Takaba, et al. · Archives of Toxicology · 19
The Digestive System of the Agouti(Dasyprocta leporina) －Gross Anatomy and Histology－
2000 · Gary Wayne GARCIA, Quinn Stephan BAPTISTE, et al. · Japanese Journal of Zoo and Wildlife Medicine · 19
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Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism
2020 · Seigo Sanoh, Yoichi Naritomi, et al. · Xenobiotica · 18
MurineCyp3aknockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans
2015 · Naoyuki Nakada, Akio Kawamura, et al. · Biopharmaceutics & Drug Disposition · 16
Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse
2002 · Masakazu Kakuni, Keiichiro Morimura, et al. · Japanese Journal of Cancer Research · 15
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Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection
2019 · Yuji Ishida, Masakazu Kakuni, et al. · Journal of Interferon & Cytokine Research · 14
Chimeric mice with human hepatocytes: A new system for genotoxicity studies
2019 · Chise Tateno, Masahito Fukumuro, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 9
Lipoprotein profile and lipid metabolism of PXB-cells®, human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs
2020 · Keishi HATA, TOMATSU Sayaka, et al. · Biomedical Research · 7
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Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic mice.
2006 · Rawiwan Puatanachokchai, Masakazu Kakuni, et al. · PubMed · 7
Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies
2022 · Masakazu Kakuni · Current Protocols · 3
Histological Study on Intestinal Diverticulum of Tree Shrew (Tupaia Javanica).
2002 · Masakazu KAKUNI, Takashi MAKITA, et al. · EXPERIMENTAL ANIMALS · 3
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Works count: 49
Citation count: 844
H-index: 17
I10-index: 20
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