Author

Greg Nicholas Brooke

Observed names: Brooke, Greg N., Brooke, Greg Nicholas, G N Brooke, G. Brooke, G. N. Brooke, G.N. Brooke, Greg Brooke, Greg N Brooke, Greg N. Brooke

Institution: University of Essex

Observed institutions: University of Essex, Queen Mary University of London, University of Cambridge, Cancer Research UK, Hammersmith Hospital, Cancer Research UK Cambridge Center, Kennedy Institute of Rheumatology, Barts Cancer Institute, University College London, Imperial College London, Newcastle University

ORCID: 0000-0003-4501-4134

Observed ORCID: 0000-0003-4501-4134

OpenAlex ID: A5020742188

The Role of Androgen Receptor Mutations in Prostate Cancer Progression

2009 · G. Brooke, C. Bevan · Current Genomics · 177

Gliotoxin Is a Dual Inhibitor of Farnesyltransferase and Geranylgeranyltransferase I with Antitumor Activity Against Breast Cancer In Vivo

2004 · D. M. Vigushin, N. Mirsaidi, et al. · Medical Oncology · 104

Prohibitin, a protein downregulated by androgens, represses androgen receptor activity

2006 · S C Gamble, D Chotai, et al. · Oncogene · 89

The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

2021 · D. A. Leach, A. Mohr, et al. · Nature Communications · 87

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Revising the role of the androgen receptor in breast cancer

2014 · F M Fioretti, A Sita-Lumsden, et al. · Journal of Molecular Endocrinology · 86

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Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression

2007 · G N Brooke, M G Parker, et al. · Oncogene · 79

FUS/TLS Is a Novel Mediator of Androgen-Dependent Cell-Cycle Progression and Prostate Cancer Growth

2010 · Greg N. Brooke, Rachel L. Culley, et al. · Cancer Research · 76

Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces

2012 · Solène Grosdidier, Laia R. Carbó, et al. · Molecular Endocrinology · 68

Structural and functional modelling of SARS-CoV-2 entry in animal models

2020 · Greg N. Brooke, Filippo Prischi · Scientific Reports · 64

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Role of the HSP90-Associated Cochaperone p23 in Enhancing Activity of the Androgen Receptor and Significance for Prostate Cancer

2012 · Vikash Reebye, Laia Querol Cano, et al. · Molecular Endocrinology · 47

Assessing Phototoxicity in a Mammalian Cell Line: How Low Levels of Blue Light Affect Motility in PC3 Cells

2021 · Rana A. Alghamdi, Marino Exposito-Rodriguez, et al. · Frontiers in Cell and Developmental Biology · 37

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The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance

2021 · Ryan Cronin, Greg N. Brooke, et al. · Oncogene · 32

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PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity

2024 · Sundarraj Jayakumar, Manthan Patel, et al. · Nature Communications · 31

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The co‐chaperone p23 promotes prostate cancer motility and metastasis

2014 · Laia Querol Cano, Derek N. Lavery, et al. · Molecular Oncology · 31

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MSC.sTRAIL Has Better Efficacy than MSC.FL-TRAIL and in Combination with AKTi Blocks Pro-Metastatic Cytokine Production in Prostate Cancer Cells

2019 · Andrea Mohr, Tianyuan Chu, et al. · Cancers · 25

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Fas-threshold signalling in MSCs promotes pancreatic cancer progression and metastasis

2021 · Andrea Mohr, Tianyuan Chu, et al. · Cancer Letters · 24

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Circulating Nucleic Acids as Biomarkers of Prostate Cancer

2013 · Ailsa Sita-Lumsden, Claire E Fletcher, et al. · Biomarkers in Medicine · 24

Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer

2014 · Bharath Rudraraju, Marjolein Droog, et al. · Breast Cancer Research and Treatment · 23

Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens

2011 · D A Dart, G N Brooke, et al. · Oncogene · 23

Nucleosome reorganisation in breast cancer tissues

2024 · Divya R. Jacob, Wilfried M. Guiblet, et al. · Clinical Epigenetics · 19

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Roles of steroid receptors in the lung and COVID-19

2021 · Damien A. Leach, Greg N. Brooke, et al. · Essays in Biochemistry · 19

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Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I

2003 · David M Vigushin, Greg Brooke, et al. · Bioorganic & Medicinal Chemistry Letters · 19

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells

2013 · Silvia Ottaviani, Greg N Brooke, et al. · Journal of Molecular Endocrinology · 18

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Mechanisms of androgen receptor repression in prostate cancer

2006 · S.M. Powell, G.N. Brooke, et al. · Biochemical Society Transactions · 18

Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer

2023 · Rebekah Anamarie Gundersen, Tianyuan Chu, et al. · Cancer Nanotechnology · 15

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Works count: 76

Citation count: 1,306

H-index: 19

I10-index: 28