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Zaihui Zhang

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors
2020 · Paul C. McDonald, Stephen Chia, et al. · American Journal of Clinical Oncology · 280
Integrin-linked kinase (ILK): a “hot” therapeutic target
2000 · T.Nathan Yoganathan, Penny Costello, et al. · Biochemical Pharmacology · 98
Applications of amide isosteres in medicinal chemistry
2019 · Shaoyi Sun, Qi Jia, et al. · Bioorganic & Medicinal Chemistry Letters · 94
Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase-1 Inhibitors as Novel Therapeutics for Human Disease
2013 · Zaihui Zhang, Natalie A. Dales, et al. · Journal of Medicinal Chemistry · 90
Lipophilic coordination compounds: aluminum, gallium, and indium complexes of 1-aryl-3-hydroxy-2-methyl-4-pyridinones
1991 · Zaihui Zhang, Steven J. Rettig, et al. · Inorganic Chemistry · 72
Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties
2002 · N. Yoganathan, A. Yee, et al. · Pharmacology & Therapeutics · 61
Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)
2011 · Jay A. Cadieux, Zaihui Zhang, et al. · Bioorganic & Medicinal Chemistry Letters · 45
Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia
2021 · Xiaojia Niu, Katharina Rothe, et al. · Blood · 41
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer
2021 · Mam Y. Mboge, Jacob Combs, et al. · Journal of Medicinal Chemistry · 40
The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Nav1.7
2014 · Shaoyi Sun, Qi Jia, et al. · Bioorganic & Medicinal Chemistry Letters · 38
Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model
2012 · Sultan Chowdhury, Shifeng Liu, et al. · Medicinal Chemistry Research · 37
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors
2012 · Zaihui Zhang, Vishnumurthy Kodumuru, et al. · Bioorganic & Medicinal Chemistry Letters · 37
Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands
2013 · Josef G. Meingassner, Heinrich Aschauer, et al. · Journal of Investigative Dermatology · 33
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Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome
2012 · Zaihui Zhang, Shaoyi Sun, et al. · Journal of Medicinal Chemistry · 33
Physical and structural studies of N-carboxymethyl- and N-(p-methoxyphenyl)-3-hydroxy-2-methyl-4-pyridinone
1992 · Zaihui Zhang, Steven J. Rettig, et al. · Canadian Journal of Chemistry · 32
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Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice
2013 · Shaoyi Sun, Richard Dean, et al. · Bioorganic & Medicinal Chemistry · 20
Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases
2013 · Shaoyi Sun, Zaihui Zhang, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Characterization of Tris(N-substituted-2-methyl-3-hydroxy-4-pyridinonato)technetium(IV) Cations
1994 · D. Scott Edwards, Shuang Liu, et al. · Inorganic Chemistry · 16
Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death
2025 · Gioele Renzi, Paul C. McDonald, et al. · European Journal of Medicinal Chemistry · 13
Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations
2023 · Katharina Köchl, Tobias Schopper, et al. · Scientific Reports · 13
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Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors
2014 · Shaoyi Sun, Zaihui Zhang, et al. · Bioorganic & Medicinal Chemistry · 13
Potential 67Ga radiopharmaceuticals for myocardial imaging: Tris(1-aryl-3-hydroxy-2-methyl-4-pyridinonato)gallium(III) complexes
1992 · Zaihui Zhang, Donald M. Lyster, et al. · International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology · 13
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage
2023 · Xianyan Hu, Rong Zou, et al. · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · 10
Abstract B148: Activity of the TAM kinase-targeting compound, SLC-391, is mediated by the engagement of the immune system in CT-26 syngeneic mouse model
2018 · Shenshen Lai, Rick Li, et al. · Molecular Cancer Therapeutics · 10
Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects
2013 · Shaoyi Sun, Zaihui Zhang, et al. · Bioorganic & Medicinal Chemistry Letters · 10
Works count: 50
Citation count: 1,215
H-index: 17
I10-index: 27
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