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Author

Lalehan Oktay

ORCID: 0000-0002-3293-5551
Observed ORCID: 0000-0002-3293-5551
OpenAlex ID: A5023228195
Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing
2021 · Serdar Durdagi, Çağdaş Dağ, et al. · Structure · 40
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The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
2021 · Serdar Durdagi, Timucin Avsar, et al. · Molecular Therapy · 35
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Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99
2018 · Haydar Çelik, Marika Sciandra, et al. · Oncogene · 33
Inhibition of altered Orai1 channels in Müller cells protects photoreceptors in retinal degeneration
2023 · Basma Sukkar, Lalehan Oktay, et al. · Glia · 8
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A Novel Algorithm for the Virtual Screening of Extensive Small Molecule Libraries Against ERCC1/XPF Protein-Protein Interaction for the Identification of Therapeutic Resistance-Bypassing Small Anticancer Molecules
2024 · Salma Ghazy, Lalehan Oktay, et al. · TURKISH JOURNAL OF BIOLOGY · 6
Developing Dynamic Structure‐Based Pharmacophore and ML‐Trained QSAR Models for the Discovery of Novel Resistance‐Free RET Tyrosine Kinase Inhibitors Through Extensive MD Trajectories and NRI Analysis
2024 · Ehsan Sayyah, Lalehan Oktay, et al. · ChemMedChem · 6
Binary-QSAR guided virtual screening of FDA approved drugs and compounds in clinical investigation against SARS-CoV-2 main protease
2021 · Serdar Durdagi, Lalehan Oktay, et al. · TURKISH JOURNAL OF BIOLOGY · 5
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Covalent docking-driven virtual screening of extensive small-molecule libraries against Bruton tyrosine kinase for the identification of highly selective and potent novel therapeutic candidates
2024 · Ezgi Sambur, Lalehan Oktay, et al. · Journal of Molecular Graphics and Modelling · 4
Developing dynamic structure-based pharmacophore and QSAR models for the discovery of novel resistance-free RET tyrosine kinase inhibitors through extensive molecular dynamics trajectories for accelerated and successful virtual screening of ultra large ligand libraries
2024 · Serdar Durdagi, Ehsan Sayyah, et al. · Biophysical Journal · 3
Utilizing Heteroatom Types and Numbers from Extensive Ligand Libraries to Develop Novel hERG Blocker QSAR Models Using Machine Learning-Based Classifiers
2023 · Safa Haddad, Lalehan Oktay, et al. · ACS Omega · 3
Niraparib Demonstrates Therapeutic Potential in Multiple Sclerosis through Inhibition of IL-17A Receptor Interaction and Promotion of Remyelination
2025 · Muge Didem Orhan, Lalehan Oktay, et al. · ACS Chemical Neuroscience · 2
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Dynamic Structure-based Pharmacophore Models for Virtual Screening of Small Molecule Libraries Targeting the YB-1
2023 · Lalehan Oktay, Ehsan Sayyah, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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New diclofenac hydrazones: Design, synthesis, in silico studies and anticancer evaluation against breast cancer
2025 · Kaan Birgül, Lalehan Oktay, et al. · Journal of Molecular Structure · 1
Abstract 1933: Discovery of first-in-class small molecule CD99 inhibitors for targeted therapy of Ewing sarcoma
2017 · Haydar Celik, Marika Sciandra, et al. · Cancer Research · 1
Prioritizing Candidate YB-1 Cold Shock Domain Ligands via 5D-ElectroShape and Boltz Generative Cofolding
2026 · Lalehan Oktay, Cem Uğuz, et al. · ACS Omega
Development of Dynamic Structure‐Based Pharmacophore Models to Target OX40–OX40L Interaction With Potential Small Molecule Therapeutics: Targeting Tumor Microenvironment
2026 · Saima Ikram, Ehsan Sayyah, et al. · ChemistrySelect
Abstract 6693: Targeting oncogenic miR-135b in colorectal cancer: Computational modeling and small molecule screening for RNA-based therapy
2025 · Berat Demir, Lalehan Oktay, et al. · Cancer Research
Targeting miRNA for Colorectal Cancer: In Silico Identification and Physics-based De Novo Modeling of Oncogenic miR-135b for Small Molecule RNA Therapy
2024 · Berat Demir, Lalehan Oktay, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Molecular modeling of PARP1 inhibition through miRNA gene silencing for the treatment of retinitis pigmentosa
2023 · Lalehan Oktay, Aylin Moayedi, et al. · Biophysical Journal
Computational drug repurposing effort for identifying novel hits against Y box binding protein 1 as a targeted therapy for ovarian cancer
2023 · Serdar Durdagi, Lalehan Oktay · Biophysical Journal
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Works count: 20
Citation count: 149
H-index: 6
I10-index: 3
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