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Walter L. Acosta

Observed names: Acosta, Walter, Walter Acosta
ORCID: 0000-0002-5525-306X
Observed ORCID: 0000-0002-5525-306X
OpenAlex ID: A5023678395
Enzyme replacement for GM1-gangliosidosis: Uptake, lysosomal activation, and cellular disease correction using a novel β-galactosidase:RTB lectin fusion
2015 · Jose Condori, Walter Acosta, et al. · Molecular Genetics and Metabolism · 53
RTB Lectin: a novel receptor-independent delivery system for lysosomal enzyme replacement therapies
2015 · Walter Acosta, Jorge Ayala, et al. · Scientific Reports · 29
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A new glucocerebrosidase deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease
2016 · Wendy Westbroek, Matthew Nguyen, et al. · Disease Models & Mechanisms · 25
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Targeting Macromolecules to CNS and Other Hard-to-Treat Organs Using Lectin-Mediated Delivery
2020 · Walter Acosta, Carole L. Cramer · International Journal of Molecular Sciences · 20
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Preclinical Enzyme Replacement Therapy with a Recombinant β-Galactosidase-Lectin Fusion for CNS Delivery and Treatment of GM1-Gangliosidosis
2022 · Jason Andrew Weesner, Ida Annunziata, et al. · Cells · 13
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High-throughput imaging method for direct assessment of GM1 ganglioside levels in mammalian cells
2016 · Walter Acosta, Reid Martin, et al. · Data in Brief · 4
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Novel bioproduction and delivery strategies for MPS IIIA enzyme replacement therapeutics
2016 · Jose Condori, Varun Katta, et al. · Molecular Genetics and Metabolism · 3
Lectin-mediated delivery of α-L-iduronidase: A novel approach for MPS I enzyme replacement therapy
2016 · Walter L. Acosta, Li Ou, et al. · Molecular Genetics and Metabolism · 3
Enzyme replacement therapy with α-L-iduronidase and lectin RTB fusion protein in treating murine Hurler syndrome
2016 · Li Ou, Walter Acosta, et al. · Molecular Genetics and Metabolism · 3
Uptake, lysosomal activation, and disease correction in GM1 Gangliosidosis cells by plant-made β-galactosidase: Lectin fusions
2016 · Jorge Ayala, Walter Acosta, et al. · Molecular Genetics and Metabolism · 2
Receptor-independent mechanisms of RTB lectin-mediated ERT delivery provide unique advantages in enzyme uptake capacity, transcytosis, and lysosomal correction
2017 · Reid Martin, Walter Acosta, et al. · Molecular Genetics and Metabolism · 1
Período de Recuperación Apoyado por STEAM en Contexto de Pandemia
2023 · Acosta, Walter, Hernández, Sandra A. · Educación en la Química
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Lectin-mediated delivery to tissues and organs affected by the development of anti-drug antibodies in MPS I mouse model
2023 · Walter Acosta, Rachel Hampton, et al. · Molecular Genetics and Metabolism
Preclinical enzyme replacement therapy with a recombinant β-galactosidase-lectin fusion for CNS delivery and treatment of GM1-gangliosidosis
2023 · Jason A. Weesner, Diantha van de Vlekkert, et al. · Molecular Genetics and Metabolism
Correction of bone pathology in MPS I mouse model using lectin-mediated delivery
2023 · Walter L. Acosta, Rachel Hampton, et al. · Molecular Genetics and Metabolism
RTB-lectin facilitates the distribution of enzymes across the blood-brain-barrier and correction in the MPS IIIA mouse model
2023 · Shivakumar D. Pattada, Jorge Ayala, et al. · Molecular Genetics and Metabolism
Intracellular stability and efficacy of β-galactosidase fusions as a GM1 gangliosidosis ERT are significantly influenced by mouse versus human multi-enzyme complex interactions
2023 · Tianhong Yang, Walter L. Acosta, et al. · Molecular Genetics and Metabolism
Works count: 17
Citation count: 156
H-index: 5
I10-index: 5
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