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Ceri M. Wiggins

ERK1/2‐dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl‐1 and Bcl‐xL
2007 · Katherine E Ewings, Kathryn Hadfield‐Moorhouse, et al. · The EMBO Journal · 180
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Bim and the Pro-Survival Bcl-2 Proteins: Opposites Attract, ERK Repels
2007 · Katherine E. Ewings, Ceri M. Wiggins, et al. · Cell Cycle · 159
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Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene‐targeted therapeutics
2009 · Annette S. Gillings, Kathryn Balmanno, et al. · FEBS Journal · 98
BIMEL, an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation
2011 · Ceri M. Wiggins, Peter Tsvetkov, et al. · Journal of Cell Science · 71
c-Cbl is not required for ERK1/2-dependent degradation of BimEL
2007 · Ceri M. Wiggins, Hamid Band, et al. · Cellular Signalling · 26
Development and Characterization of a Modular CRISPR and RNA Aptamer Mediated Base Editing System
2021 · Juan Carlos Collantes, Victor M. Tan, et al. · The CRISPR Journal · 18
Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent
2016 · Emma J. Haagensen, Huw D. Thomas, et al. · European Journal of Cancer · 17
An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation
2024 · Immacolata Porreca, Robert Blassberg, et al. · Molecular Therapy · 16
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A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds
2017 · Claire J. Cairney, Lauren S. Godwin, et al. · PLoS Genetics · 13
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Refining the minimal sequence required for ERK1/2-dependent poly-ubiquitination and proteasome-dependent turnover of BIM
2010 · Ceri M. Wiggins, Mark Johnson, et al. · Cellular Signalling · 10
Abstract 4289: 3-Dimensional growth reveals KRAS dependency.
2013 · Rebecca Foster, Clare Mudd, et al. · Cancer Research · 3
Hit screening with multivariate robust outlier detection
2024 · Hui Sun Leong, Tianhui Zhang, et al. · PLoS ONE · 2
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Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells
2023 · Anna Dickson, Niamh Mullooly, et al. · SLAS DISCOVERY · 2
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Abstract 700: Investigating KRAS synthetic lethal/co-dependency interactions using siRNA and CRISPR
2015 · Simon F. Scrace, Elpida Tsonou, et al. · Cancer Research · 1
CRISPR screening in primary human lung fibroblasts and small airway epithelial cells identifies novel targets to reduce cellular senescence with potential to treat both COPD and IPF
2023 · Johan Mattsson, Jenna Bradley, et al. · European Respiratory Journal
Identification of negative regulators of Wnt/β-catenin signaling in lung epithelial cells through whole genome CRISPR screen
2023 · Markus Tammia, Anna Dickson, et al. · European Respiratory Journal
Abstract 1927: High-throughput cell line panel drug screening in organoids and 3D systems
2019 · Tim M. Scales, Anett Rada-Kovacs, et al. · Tumor Biology
Abstract 1927: High-throughput cell line panel drug screening in organoids and 3D systems
2019 · Tim M. Scales, Anett Rada-Kovacs, et al. · Cancer Research
Abstract 2912: CRISPR-Cas9: A tool for rapid target discovery and validation
2018 · Ceri M. Wiggins, David Walter, et al. · Cancer Research
Abstract A25: Synthetic lethal CRISPR-Cas9 screen imply an oncogenic role for FBXW7 mutations in colon cancer
2017 · Jonathan D. Moore, Chantelle Hudson, et al. · Molecular Cancer Therapeutics
Identifying synthetic lethal targets in colon cancer using CRISPR-Cas9 and siRNA screens
2016 · P. Russell, D. Walter, et al. · European Journal of Cancer
Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent
2016 · Emma Haagensen, Huw Thomas, et al. · Newcastle University ePrints (Newcastle Univesity)
The In(del)s and Outs of CRISPR-Cas9 Screens
2016 · Ceri Wiggins, Steffen Lawo · Genetic Engineering & Biotechnology News
Abstract 2137: Using Rac1 isogenic cells to model tumor metastasis
2012 · Ceri Wiggins, Holly Astley, et al. · Cancer Research
Works count: 24
Citation count: 616
H-index: 10
I10-index: 10
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