Author

Saaïd Safieddine

Observed names: S. Safieddine, Saaid Safieddine, Safieddine, Saaid

Institutions: Centre National de la Recherche Scientifique, Inserm, Institut Pasteur, Université Paris Cité, Université Paris-Saclay, Assistance Publique – Hôpitaux de Paris, Bicêtre Hospital, Fondation Pour l'Audition, Institut de l'Audition

Observed institutions: Centre National de la Recherche Scientifique, National Institutes of Health, Inserm, Institut Pasteur, Universität Hamburg, Collège de France, Université Paris Cité, Université Paris-Saclay, Sorbonne Université, Centre Hospitalier Universitaire de Montpellier, Assistance Publique – Hôpitaux de Paris, Hôpital Saint Charles, National Institute on Deafness and Other Communication Disorders, Bicêtre Hospital, Université Montpellier 2, Université Pierre-et-Marie-Curie, Fondation Pour l'Audition, Institut de l'Audition

ORCID: 0000-0002-6159-0572

Observed ORCID: 0000-0002-6159-0572

OpenAlex ID: A5024266430

Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse

2006 · Isabelle Roux, Saaid Safieddine, et al. · Cell · 753

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KCNQ4, a K + channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway

2000 · Tatjana Kharkovets, Jean-Pierre Hardelin, et al. · Proceedings of the National Academy of Sciences · 401

Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model

2019 · Omar Akil, Frank Dyka, et al. · Proceedings of the National Academy of Sciences · 302

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Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin–catenins complex

2000 · Polonca Küssel‐Andermann, Aziz El‐Amraoui, et al. · The EMBO Journal · 229

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

2015 · Sedigheh Delmaghani, Jean Defourny, et al. · Cell · 221

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The Auditory Hair Cell Ribbon Synapse: From Assembly to Function

2012 · Saaid Safieddine, Aziz El-Amraoui, et al. · Annual Review of Neuroscience · 209

SNARE complex at the ribbon synapses of cochlear hair cells: analysis of synaptic vesicle‐ and synaptic membrane‐associated proteins

1999 · Saaid Safieddine, Robert J. Wenthold · European Journal of Neuroscience · 202

Control of Exocytosis by Synaptotagmins and Otoferlin in Auditory Hair Cells

2010 · Maryline Beurg, Nicolas Michalski, et al. · Journal of Neuroscience · 154

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Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

2017 · Nicolas Michalski, Juan D Goutman, et al. · eLife · 152

Deafness: from genetic architecture to gene therapy

2023 · Christine Petit, Crystel Bonnet, et al. · Nature Reviews Genetics · 149

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Otoferlin Is Critical for a Highly Sensitive and Linear Calcium-Dependent Exocytosis at Vestibular Hair Cell Ribbon Synapses

2009 · Didier Dulon, Saaid Safieddine, et al. · Journal of Neuroscience · 149

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Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome

2018 · Didier Dulon, Samantha Papal, et al. · Journal of Clinical Investigation · 146

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Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G

2017 · Alice Emptoz, Vincent Michel, et al. · Proceedings of the National Academy of Sciences · 141

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Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses

2009 · Isabelle Roux, Suzanne Hosie, et al. · Human Molecular Genetics · 125

Calcium- and Otoferlin-Dependent Exocytosis by Immature Outer Hair Cells

2008 · Maryline Beurg, Saaid Safieddine, et al. · Journal of Neuroscience · 97

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Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

2018 · Laura F. Corns, Stuart L. Johnson, et al. · Nature Communications · 89

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Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders

2019 · Anne G. M. Schilder, Matthew P. Su, et al. · Otology & Neurotology · 88

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Choline Acetyltransferase, Glutamate Decarboxylase, Tyrosine Hydroxylase, Calcitonin Gene‐related Peptide and Opioid Peptides Coexist in Lateral Efferent Neurons of Rat and Guinea‐pig

1997 · Saaid Safieddine, Ana Maria Soto Prior, et al. · European Journal of Neuroscience · 82

Co-expression of NMDA and AMPA/kainate receptor mRNAs in cochlear neurones

1992 · Saaid Safieddine, Michael Eybalin · Neuroreport · 78

Triple Immunofluorescence Evidence for the Coexistence of Acetylcholine, Enkephalins and Calcitonin Gene‐related Peptide Within Efferent (Olivocochlear) Neurons of Rats and Guinea‐pigs

1992 · Saaid Safieddine, Michel Eybalin · European Journal of Neuroscience · 71

αII-βV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells

2008 · Kirian Legendre, Saaid Safieddine, et al. · Journal of Cell Science · 70

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Chapter 8 Mouse Models for Human Hereditary Deafness

2008 · Michel Leibovici, Saaid Safieddine, et al. · Current topics in developmental biology/Current Topics in Developmental Biology · 68

The Glutamate Receptor Subunit δ1 Is Highly Expressed in Hair Cells of the Auditory and Vestibular Systems

1997 · Saaid Safieddine, Robert J. Wenthold · Journal of Neuroscience · 68

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Exocytotic Machineries of Vestibular Type I and Cochlear Ribbon Synapses Display Similar Intrinsic Otoferlin-Dependent Ca2+ Sensitivity But a Different Coupling to Ca2+ Channels

2014 · P. F. Y. Vincent, Y. Bouleau, et al. · Journal of Neuroscience · 66

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Unconventional Myosin VIIA Is a Novel A-kinase-anchoring Protein

2000 · Polonca Küssel-Andermann, Aziz El-Amraoui, et al. · Journal of Biological Chemistry · 64

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Works count: 69

Citation count: 4,734

H-index: 33

I10-index: 40