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Nadezhda S. Dyrkheeva

Observed names: Dyrkheeva, Nadezhda S., N S Dyrkheeva, N. S. Dyrkheeva, N.S. Dyrkheeva, Nadezhda Dyrkheeva, Nadezhda S Dyrkheeva, Nadezhda.S. Dyrkheeva, ДЫРХЕЕВА Н.С., Дырхеева Н.С., Н. С. Дырхеева, Н.С. Дырхеева
Observed institutions: National Institutes of Health, Russian Academy of Sciences, Novosibirsk State University, Institute of Chemical Biology and Fundamental Medicine, National Institute of Environmental Health Sciences, Siberian Branch of the Russian Academy of Sciences
ORCID: 0000-0002-8360-1041
Observed ORCID: 0000-0002-8360-1041
OpenAlex ID: A5024516955
Capturing snapshots of APE1 processing DNA damage
2015 · Bret D Freudenthal, William A Beard, et al. · Nature Structural & Molecular Biology · 175
Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin
2016 · Alexandra Zakharenko, Olga Luzina, et al. · Journal of Natural Products · 82
Contamination of exosome preparations, isolated from biological fluids
2017 · A.E. Grigor'eva, N.S. Dyrkheeva, et al. · Biomeditsinskaya Khimiya · 66
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Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair
2015 · Rajendra Prasad, Nadezhda Dyrkheeva, et al. · PLoS ONE · 58
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Dual DNA topoisomerase 1 and tyrosyl‐DNA phosphodiesterase 1 inhibition for improved anticancer activity
2019 · Alexandra Zakharenko, Nadezhda Dyrkheeva, et al. · Medicinal Research Reviews · 48
AP endonuclease 1 as a key enzyme in repair of apurinic/apyrimidinic sites
2016 · N. S. Dyrkheeva, N. A. Lebedeva, et al. · Biochemistry (Moscow) · 48
New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors
2019 · Aleksander S. Filimonov, Arina A. Chepanova, et al. · Molecules · 46
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Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
2023 · Alexandra L. Zakharenko, Olga A. Luzina, et al. · International Journal of Molecular Sciences · 37
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Usnic Acid Conjugates with Monoterpenoids as Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
2020 · Olga Luzina, Alexander Filimonov, et al. · Journal of Natural Products · 35
Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1
2020 · Irina V. Il’ina, Nadezhda S. Dyrkheeva, et al. · Molecules · 34
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Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors
2018 · Olga Zakharova, Olga Luzina, et al. · Bioorganic & Medicinal Chemistry · 34
Contamination of exosome preparations, isolated from biological fluids
2017 · A. E. Grigor’eva, N. S. Dyrkheeva, et al. · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · 33
Base Excision Repair of Tandem Modifications in a Methylated CpG Dinucleotide
2014 · Akira Sassa, Melike Çağlayan, et al. · Journal of Biological Chemistry · 31
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Multifunctional human apurinic/apyrimidinic endonuclease 1: Role of additional functions
2007 · N. S. Dyrkheeva, S. N. Khodyreva, et al. · Molecular Biology · 30
The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
2020 · Elizaveta D. Gladkova, Ivan V. Nechepurenko, et al. · International Journal of Molecular Sciences · 29
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New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1
2021 · Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, et al. · International Journal of Molecular Sciences · 28
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New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
2021 · Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, et al. · Biomolecules · 28
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Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments
2021 · Aldar A. Munkuev, Evgenii S. Mozhaitsev, et al. · Molecules · 28
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Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study
2020 · Oksana V. Salomatina, Irina I. Popadyuk, et al. · Steroids · 27
Efficiency of exonucleolytic action of apurinic/apyrimidinic endonuclease 1 towards matched and mismatched dNMP at the 3′ terminus of different oligomeric DNA structures correlates with thermal stability of DNA duplexes
2006 · Nadezhda S. Dyrkheeva, Alexander A. Lomzov, et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 27
DNA complexes with human apurinic/apyrimidinic endonuclease 1: structural insights revealed by pulsed dipolar EPR with orthogonal spin labeling
2019 · Olesya A Krumkacheva, Georgiy Yu Shevelev, et al. · Nucleic Acids Research · 26
Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells
2019 · Kseniya Kovaleva, Olga Oleshko, et al. · Journal of Natural Products · 22
Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
2018 · Anastasia O. Komarova, Mikhail S. Drenichev, et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 22
Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1
2017 · A. L. Zakharenko, O. A. Luzina, et al. · Russian Journal of Bioorganic Chemistry · 21
3′–5′ exonuclease activity of human apurinic/apyrimidinic endonuclease 1 towards DNAs containing dNMP and their modified analogs at the 3′ end of single strand DNA break
2006 · N. S. Dyrkheeva, S. N. Khodyreva, et al. · Biochemistry (Moscow) · 18
Works count: 83
Citation count: 1,300
H-index: 22
I10-index: 35
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