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Stephen Boulton
Observed name:
Boulton, Stephen
Institutions:
University of Ottawa,
Ottawa Hospital Research Institute
Observed institutions:
University of Ottawa,
Ottawa Hospital Research Institute,
Michael G. DeGroote Institute for Infectious Disease Research,
McMaster University
ORCID:
0000-0002-2521-2240
Observed ORCID:
0000-0002-2521-2240
OpenAlex ID:
A5024735414
Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”
2015
·
Yingmin Zhu
, Haijun Chen
, et al.
·
Scientific Reports
·
106
PDF
Advances in NMR Methods To Map Allosteric Sites: From Models to Translation
2016
·
Stephen Boulton
, Giuseppe Melacini
·
Chemical Reviews
·
92
Extracellular Vesicles and Viruses: Two Intertwined Entities
2023
·
Coline Moulin
, Mathieu J. F. Crupi
, et al.
·
International Journal of Molecular Sciences
·
91
PDF
A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP
2014
·
Madoka Akimoto
, Zaiyong Zhang
, et al.
·
Journal of Biological Chemistry
·
79
A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
2014
·
Stephen Boulton
, Madoka Akimoto
, et al.
·
Scientific Reports
·
67
PDF
Atomic resolution map of the soluble amyloid beta assembly toxic surfaces
2019
·
Rashik Ahmed
, Michael Akcan
, et al.
·
Chemical Science
·
66
PDF
Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies
2023
·
Taha Azad
, Reza Rezaei
, et al.
·
Nature Communications
·
45
PDF
Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist
2018
·
Stephen Boulton
, Rajeevan Selvaratnam
, et al.
·
Journal of the American Chemical Society
·
43
Characterization of Critical Determinants of ACE2–SARS CoV-2 RBD Interaction
2021
·
Emily E. F. Brown
, Reza Rezaei
, et al.
·
International Journal of Molecular Sciences
·
34
PDF
Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer
2022
·
Mathieu J. F. Crupi
, Zaid Taha
, et al.
·
Frontiers in Immunology
·
32
PDF
SARS-CoV-2 S1 NanoBiT: A nanoluciferase complementation-based biosensor to rapidly probe SARS-CoV-2 receptor recognition
2021
·
Taha Azad
, Ragunath Singaravelu
, et al.
·
Biosensors and Bioelectronics
·
32
Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators
2019
·
Stephen Boulton
, Rajeevan Selvaratnam
, et al.
·
Journal of Medicinal Chemistry
·
30
Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis
2020
·
Taha Azad
, Reza Rezaei
, et al.
·
Cancers
·
28
PDF
Engineering vaccinia virus as an immunotherapeutic battleship to overcome tumor heterogeneity
2020
·
Adrian Pelin
, Stephen Boulton
, et al.
·
Expert Opinion on Biological Therapy
·
28
Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist’s Approach to Allostery
2017
·
Stephen Boulton
, Rajeevan Selvaratnam
, et al.
·
Methods in molecular biology
·
26
Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry
2021
·
Taha Azad
, Ragunath Singaravelu
, et al.
·
Molecular Therapy
·
25
Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
2020
·
Taha Azad
, Ragunath Singaravelu
, et al.
·
Membranes
·
24
PDF
Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective
2019
·
Alveena Ahmed
, Stephen Boulton
, et al.
·
Cells
·
24
PDF
Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection
2021
·
Stephen Boulton
, Joanna Poutou
, et al.
·
Molecular Therapy
·
23
PDF
Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia
2017
·
Stephen Boulton
, Madoka Akimoto
, et al.
·
Journal of Biological Chemistry
·
23
Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist
2020
·
Hongzhao Shao
, Hebatallah Mohamed
, et al.
·
Journal of Medicinal Chemistry
·
20
‘AND’ logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7
2016
·
Ahmad W. Almawi
, Lindsay A. Matthews
, et al.
·
Scientific Reports
·
19
PDF
Allosteric linkers in cAMP signalling
2014
·
Madoka Akimoto
, Kody Moleschi
, et al.
·
Biochemical Society Transactions
·
17
CHESPA/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery
2020
·
Hongzhao Shao
, Stephen Boulton
, et al.
·
Bioinformatics
·
16
PDF
Complementary dual-virus strategy drives synthetic target and cognate T-cell engager expression for endogenous-antigen agnostic immunotherapy
2024
·
Zaid Taha
, Mathieu Joseph François Crupi
, et al.
·
Nature Communications
·
15
PDF
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Works count:
48
Citation count:
1,146
H-index:
20
I10-index:
31
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