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Hiroaki Takubo

A Possible Mechanism of Eighteen Patient Deaths Caused by Interactions of Sorivudine, a New Antiviral Drug, with Oral 5-Fluorouracil Prodrugs
1998 · Haruhiro Okuda, Kenichiro Ogura, et al. · Journal of Pharmacology and Experimental Therapeutics · 155
Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients
2014 · Hiroyuki Sayama, Hiroaki Takubo, et al. · The AAPS Journal · 57
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Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine
1998 · Kenichiro Ogura, Takahito Nishiyama, et al. · Cancer Letters · 39
Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver
2018 · Keigo Nakayama, Soichiro Ito, et al. · Xenobiotica · 20
Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application ofmdr1aknockout (−/−) rats into absorption study of multiple transporter substrate
2014 · Motoya Suzuki, Hiroshi Komura, et al. · Xenobiotica · 11
Quantitative Prediction of Drug-Drug Interactions Caused by CYP3A Induction Using Endogenous Biomarker 4β-Hydroxycholesterol
2024 · Hiroaki Takubo, Toshio Taniguchi, et al. · Drug Metabolism and Disposition · 9
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Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I
2022 · Hiroaki Takubo, Koji Bessho, et al. · Xenobiotica · 9
Prediction of CYP3A-mediated drug–drug interactions using endogenous biomarkers 6β-hydroxycortisol and cortisol
2025 · Hiroaki Takubo, Toshio Taniguchi, et al. · Drug Metabolism and Disposition · 7
Pharmacokinetics and disposition of dalcetrapib in rats and monkeys
2014 · Hiroaki Takubo, Tomohiro Ishikawa, et al. · Xenobiotica · 7
Evaluation of the changes in exposure to thiol compounds in chronic kidney disease patients using the PBPK model
2020 · Hiroaki Takubo, Toshio Taniguchi, et al. · Xenobiotica · 3
Quantitative prediction of drug-drug interactions arising from CYP3A4 induction using chimeric mice with humanized liver
2025 · Keigo Nakayama, Tamotsu Negoro, et al. · Xenobiotica · 2
The influence of multiple oral administration on the pharmacokinetics and distribution profile of dalcetrapib in rats
2020 · Hiroaki Takubo, Tomohiro Ishikawa, et al. · Xenobiotica · 1
Works count: 14
Citation count: 320
H-index: 7
I10-index: 5
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