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Author

Ian R Outhwaite

Observed names: I.R. Outhwaite, Ian Outhwaite, Ian R. Outhwaite, Outhwaite, Ian, Outhwaite, Ian R.
ORCID: 0000-0003-2037-3261
Observed ORCID: 0000-0003-2037-3261
OpenAlex ID: A5024976311
Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
2020 · Xiaowei Hou, Ian R. Outhwaite, et al. · eLife · 57
Allosteric regulation and inhibition of protein kinases
2023 · Victoria R. Mingione, YiTing Paung, et al. · Biochemical Society Transactions · 49
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Discovery and molecular basis of subtype-selective cyclophilin inhibitors
2022 · Alexander A. Peterson, Aziz M. Rangwala, et al. · Nature Chemical Biology · 36
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Motivation to Impact: Medical Student Volunteerism in the COVID 19 Pandemic
2022 · Hannah E. Phillips, Rebecca B. Jennings, et al. · Medical Science Educator · 20
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Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib
2024 · Ariel Leyte-Vidal, RosaAnna DeFilippis, et al. · Leukemia · 17
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Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting
2023 · Ian R. Outhwaite, Sukrit Singh, et al. · eLife · 11
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo
2024 · Daniel P. Radin, Sophie Shifman, et al. · Journal of Pharmacology and Experimental Therapeutics · 10
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The Effects of the Physical and Professional Workplace Environments on the Well-Being of Nursing Staff
2025 · Rebecca Jennings, Ian Outhwaite, et al. · AJN American Journal of Nursing · 9
Probing conformational dynamics to understand kinase inhibition
2023 · Ian R Outhwaite, Markus A Seeliger · eLife · 5
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Resistance to Allosteric Inhibitors
2025 · Ian R. Outhwaite, Isabelle Kwan, et al. · Journal of Molecular Biology · 4
Source data for "A design approach for bitopic kinase inhibitors"
2026 · Stevenson, Jack, Lou, Kevin, et al. · Zenodo (CERN European Organization for Nuclear Research) · 1
Molecular dynamics, ANM, and druggability simulation data for "High-Throughput Crystallographic Fragment Screening of Cyclophilin D: A Structural Atlas and Resource for Inhibitor Discovery"
2026 · Gebauer, Emma L., Kreitler, Dale F., et al. · Zenodo (CERN European Organization for Nuclear Research)
A design approach for bitopic kinase inhibitors
2026 · Jack W. Stevenson, Kevin Lou, et al. · Nature
Numerous clinically-detected asciminib-resistant BCR::ABL1 mutations disrupt allostery and confer cross-resistance to the novel clinically-active allosteric TKI tgrx-678
2025 · Ariel Leyte-Vidal, Ian Outhwaite, et al. · Blood
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Author response: Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting
2023 · Ian R Outhwaite, Sukrit Singh, et al. · eLife
Author response: Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
2020 · Xiaowei Hou, Ian R Outhwaite, et al. · eLife
Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody
2020 · S.B. Long, X. Hou, et al. · Worldwide Protein Data Bank
Works count: 17
Citation count: 219
H-index: 8
I10-index: 7
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