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Paolo Orsini

Observed name: P. Orsini
ORCID: 0009-0000-8427-0945
Observed ORCID: 0009-0000-8427-0945
OpenAlex ID: A5025261960
Entrectinib, a Pan–TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications
2016 · Elena Ardini, Maria Menichincheri, et al. · Molecular Cancer Therapeutics · 335
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Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor
2016 · Maria Menichincheri, Elena Ardini, et al. · Journal of Medicinal Chemistry · 311
Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors
2010 · Roberto T. Bossi, M. Beatrice Saccardo, et al. · Biochemistry · 174
3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding
2004 · Paolo Pevarello, Maria Gabriella Brasca, et al. · Journal of Medicinal Chemistry · 167
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy
2015 · Gianluca Papeo, Helena Posteri, et al. · Journal of Medicinal Chemistry · 150
3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization
2005 · Paolo Pevarello, Maria Gabriella Brasca, et al. · Journal of Medicinal Chemistry · 110
Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
2008 · Ermes Vanotti, Raffaella Amici, et al. · Journal of Medicinal Chemistry · 93
Synthesis of the C-1−C-28 ABCD Unit of Spongistatin 1
2003 · Matthew J. Gaunt, Alan S. Jessiman, et al. · Organic Letters · 85
Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo‐Symmetry
2005 · Matthew Ball, Matthew J. Gaunt, et al. · Angewandte Chemie International Edition · 80
Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis
2002 · Matthew J. Gaunt, Helen F. Sneddon, et al. · Organic & Biomolecular Chemistry · 74
First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery
2008 · Maria Menichincheri, Alberto Bargiotti, et al. · Journal of Medicinal Chemistry · 71
An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
2019 · Renata Sano, Kateryna Krytska, et al. · Science Translational Medicine · 70
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Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing
2010 · Maria Gabriella Brasca, Clara Albanese, et al. · Bioorganic & Medicinal Chemistry · 66
Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding
2010 · Maria Menichincheri, Clara Albanese, et al. · Journal of Medicinal Chemistry · 63
Anaplastic Lymphoma Kinase: Role in specific tumours, and development of small molecule inhibitors for cancer therapy
2010 · E. Ardini, P. Magnaghi, et al. · Cancer Letters · 59
Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515
2019 · Gianluca Papeo, Paolo Orsini, et al. · ACS Medicinal Chemistry Letters · 49
Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?
2009 · Gianluca Papeo, Barbara Forte, et al. · Expert Opinion on Therapeutic Patents · 38
Abstract A243: Characterization of NMS-E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK-dependent lymphoma and non-small cell lung cancer models
2009 · Elena Ardini, Maria Menichincheri, et al. · Molecular Cancer Therapeutics · 32
6‐Substituted Pyrrolo[3,4‐c]pyrazoles: An Improved Class of CDK2 Inhibitors
2007 · Maria Gabriella Brasca, Clara Albanese, et al. · ChemMedChem · 27
EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors
2021 · Emily Capone, Rossano Lattanzio, et al. · Pharmaceutics · 19
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Highly efficient synthesis of 5-benzyl-3-aminoindazoles
2009 · Paolo Orsini, Maria Menichincheri, et al. · Tetrahedron Letters · 18
Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo‐Symmetry
2005 · Matthew Ball, Matthew J. Gaunt, et al. · Angewandte Chemie · 14
Present Scenario and Future Landscape of Payloads for ADCs: Focus on DNA-Interacting Agents
2024 · Barbara Valsasina, Paolo Orsini, et al. · Pharmaceuticals · 13
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Abstract 2092: The ALK inhibitor NMS-E628 also potently inhibits ROS1 and induces tumor regression in ROS-driven models .
2013 · Elena Ardini, Maria Menichincheri, et al. · Cancer Research · 10
Regioselective γ-Alkylation of tert-Butyl 2,4-Dioxopiperidine-1-carboxylate
2007 · Paolo Orsini, Alessandro Maccario, et al. · Synthesis · 10
Works count: 74
Citation count: 2,189
H-index: 19
I10-index: 25
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