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Didier Scherrer
Observed names:
D Scherrer,
D. Scherrer,
Scherrer Didier
Institution:
Abivax (France)
Observed institutions:
Centre National de la Recherche Scientifique,
Inserm,
Université de Montpellier,
Institut de Génétique Moléculaire de Montpellier,
Stanford Medicine,
Abivax (France),
Université de Strasbourg,
Stanford University
show all 8
ORCID:
0000-0001-9835-8550
Observed ORCID:
0000-0001-9835-8550
OpenAlex ID:
A5025864006
Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis
2015
·
Noëlie Campos
, Renier Myburgh
, et al.
·
Retrovirology
·
99
PDF
ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase 2b, double-blind, randomised, placebo-controlled induction trial and 48 week, open-label extension
2022
·
Severine Vermeire
, Bruce E Sands
, et al.
·
The Lancet. Gastroenterology & hepatology
·
70
RabGEF1 is a negative regulator of mast cell activation and skin inflammation
2004
·
See-Ying Tam
, Mindy Tsai
, et al.
·
Nature Immunology
·
68
Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing
2019
·
Audrey Vautrin
, Laurent Manchon
, et al.
·
Scientific Reports
·
66
PDF
Interleukin-1beta induces bradykinin B2 receptor gene expression through a prostanoid cyclic AMP-dependent pathway in human bronchial smooth muscle cells.
1998
·
F Schmidlin
, D Scherrer
, et al.
·
PubMed
·
59
Specific and selective induction of miR-124 in immune cells by the quinoline ABX464: a transformative therapy for inflammatory diseases
2020
·
Jamal Tazi
, Christina Begon-Pescia
, et al.
·
Drug Discovery Today
·
54
PDF
The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages
2017
·
Karim Chebli
, Laura Papon
, et al.
·
Scientific Reports
·
36
PDF
Safety and efficacy of the miR-124 upregulator ABX464 (obefazimod, 50 and 100 mg per day) in patients with active rheumatoid arthritis and inadequate response to methotrexate and/or anti-TNFα therapy: a placebo-controlled phase II study
2022
·
Claire Daien
, Marek Krogulec
, et al.
·
Annals of the Rheumatic Diseases
·
33
PDF
ABX464 (Obefazimod) Upregulates miR-124 to Reduce Proinflammatory Markers in Inflammatory Bowel Diseases
2022
·
Cécile Apolit
, Noëlie Campos
, et al.
·
Clinical and Translational Gastroenterology
·
32
Obefazimod: A First-in-class Drug for the Treatment of Ulcerative Colitis
2023
·
Séverine Vermeire
, Virginia Solitano
, et al.
·
Journal of Crohn s and Colitis
·
27
Interleukin-1β Induces Bradykinin B2 Receptor Gene Expression through a Prostanoid Cyclic AMP-Dependent Pathway in Human Bronchial Smooth Muscle Cells
1998
·
Fabien Schmidlin
, Didier Scherrer
, et al.
·
Molecular Pharmacology
·
23
Safety, Pharmacokinetics, and Antiviral Activity of a Novel HIV Antiviral, ABX464, in Treatment-Naive HIV-Infected Subjects in a Phase 2 Randomized, Controlled Study
2017
·
Jean-Marc Steens
, Didier Scherrer
, et al.
·
Antimicrobial Agents and Chemotherapy
·
21
Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study
2019
·
Sofie Rutsaert
, Jean-Marc Steens
, et al.
·
Journal of Virus Eradication
·
20
PDF
Pharmacokinetics and tolerability of ABX464, a novel first-in-class compound to treat HIV infection, in healthy HIV-uninfected subjects
2016
·
Didier Scherrer
, Regine Rouzier
, et al.
·
Journal of Antimicrobial Chemotherapy
·
20
Obefazimod in patients with moderate-to-severely active ulcerative colitis: efficacy and safety analysis from the 96-week open-label maintenance phase 2b study
2025
·
Severine Vermeire
, Josianne Nitcheu
, et al.
·
Journal of Crohn s and Colitis
·
18
PDF
Glucocorticoids inhibit the bradykinin B2 receptor increase induced by interleukin-1β in human bronchial smooth muscle cells
1998
·
Fabien Schmidlin
, Didier Scherrer
, et al.
·
European Journal of Pharmacology
·
18
Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea‐pig trachea
1995
·
Didier Scherrer
, Laurent Daeffler
, et al.
·
British Journal of Pharmacology
·
18
PDF
Randomized Trial of Food Effect on Pharmacokinetic Parameters of ABX464 Administered Orally to Healthy Male Subjects
2016
·
Didier Scherrer
, Regine Rouzier
, et al.
·
Antimicrobial Agents and Chemotherapy
·
14
Glucocorticoid modulation of muscarinic and β‐adrenergic receptors in guinea pig lung
1997
·
D. Scherrer
, E. Lach
, et al.
·
Fundamental and Clinical Pharmacology
·
13
Glucocorticoids increase bradykinin B2 receptor gene transcription in cultured guinea-pig tracheal smooth muscle cells
1999
·
Didier Scherrer
, Fabien Schmidlin
, et al.
·
Naunyn-Schmiedeberg s Archives of Pharmacology
·
11
Impact of Obefazimod on Viral Persistence, Inflammation, and Immune Activation in People With Human Immunodeficiency Virus on Suppressive Antiretroviral Therapy
2023
·
Silvia Bernal
, Maria C Puertas
, et al.
·
The Journal of Infectious Diseases
·
10
PDF
Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice
2016
·
J Santo
, C Lopez-Herrera
, et al.
·
International Journal of Obesity
·
9
M2-Muscarinic Receptors: How Does Ligand Binding Affinity Relate to Intrinsic Activity?
1996
·
J. G. Van Gelderen
, L. Daeffler
, et al.
·
Journal of Receptors and Signal Transduction
·
8
Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse Models
2022
·
Didier Scherrer
, Noel Barrett
, et al.
·
Molecular Cancer Therapeutics
·
5
PDF
RNA sequencing analysis of activated macrophages treated with the anti-HIV ABX464 in intestinal inflammation
2017
·
Laurent Manchon
, Karim Chebli
, et al.
·
Scientific Data
·
5
PDF
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Works count:
55
Citation count:
784
H-index:
17
I10-index:
21
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