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Author

Laura Maccari

Observed names: L. MACCARI, L. Maccari, MACCARI L
Institution: University of Siena
ORCID: 0000-0002-3133-8958
Observed ORCID: 0000-0002-3133-8958
OpenAlex ID: A5026292764
Synthesis, Biological Evaluation, and Pharmacophore Generation of New Pyridazinone Derivatives with Affinity toward α1- and α2-Adrenoceptors
2001 · Roberta Barbaro, Laura Betti, et al. · Journal of Medicinal Chemistry · 120
Straightforward Recursive Partitioning Model for Discarding Insoluble Compounds in the Drug Discovery Process
2008 · Claudia Lamanna, Marta Bellini, et al. · Journal of Medicinal Chemistry · 84
Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine
2004 · Oriol Pineda, Jaume Farràs, et al. · Bioorganic & Medicinal Chemistry Letters · 73
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection
2019 · Annalaura Brai, Francesco Martelli, et al. · Journal of Medicinal Chemistry · 56
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor
2019 · Anna Lucia Fallacara, Claudio Zamperini, et al. · Cancers · 44
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A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours
2015 · Madhuri Kalathur, Alberto Toso, et al. · Nature Communications · 44
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Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line
2019 · Francesco P Cammarata, Filippo Torrisi, et al. · International Journal of Molecular Sciences · 41
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α 1 -Adrenoceptor Antagonists. 4. Pharmacophore-Based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives
2002 · Laura Betti, Maurizio Botta, et al. · Journal of Medicinal Chemistry · 39
Synthesis and biological activity of new 1,4-benzodioxan-arylpiperazine derivatives. Further validation of a pharmacophore model for α1-adrenoceptor antagonists
2002 · Roberta Barbaro, Laura Betti, et al. · Bioorganic & Medicinal Chemistry · 39
3D QSAR Models of Interactions Between β-Tubulin and Microtubule Stabilizing Antimitotic Agents (MSAA): A Survey on Taxanes and Epothilones
2004 · Fabrizio Manetti, Laura Maccari, et al. · Current Topics in Medicinal Chemistry · 33
Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)
2010 · Chiara Ghiron, Simon N. Haydar, et al. · Journal of Medicinal Chemistry · 30
α1-Adrenoceptor Antagonists. 6. Structural Optimization of Pyridazinone−Arylpiperazines. Study of the Influence on Affinity and Selectivity of Cyclic Substituents at the Pyridazinone Ring and Alkoxy Groups at the Arylpiperazine Moiety
2003 · Laura Betti, Federico Corelli, et al. · Journal of Medicinal Chemistry · 30
3D QSAR studies of the interaction between β-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones
2003 · Fabrizio Manetti, Stefano Forli, et al. · Il Farmaco · 29
SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines
2020 · Filippo Torrisi, Luigi Minafra, et al. · International Journal of Molecular Sciences · 26
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Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)
2012 · Riccardo Zanaletti, Laura Bettinetti, et al. · Journal of Medicinal Chemistry · 26
The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I
2015 · Elisa Oppici, Riccardo Montioli, et al. · ACS Chemical Biology · 22
Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor
2014 · Arianna Nencini, Cristiana Castaldo, et al. · European Journal of Medicinal Chemistry · 21
A Genetic-Function-Approximation-Based QSAR Model for the Affinity of Arylpiperazines toward α1Adrenoceptors
2006 · Laura Maccari, Matteo Magnani, et al. · Journal of Chemical Information and Modeling · 18
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains
2019 · Francesco Orofino, Giuseppina I. Truglio, et al. · International Journal of Antimicrobial Agents · 17
Identification of novel nt-MGAM inhibitors for potential treatment of type 2 diabetes: Virtual screening, atom based 3D-QSAR model, docking analysis and ADME study
2017 · Aicha Laoud, Fouad Ferkous, et al. · Computational Biology and Chemistry · 15
Novel Hits in the Correction of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis
2015 · Elisabetta Pesci, Laura Bettinetti, et al. · Journal of Medicinal Chemistry · 14
N-[5-(5-Fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate
2012 · Riccardo Zanaletti, Laura Bettinetti, et al. · Journal of Medicinal Chemistry · 14
A Homogeneous HTRF Assay for the Identification of Inhibitors of the TWEAK-Fn14 Protein Interaction
2012 · Tiziana Benicchi, Sara Iozzi, et al. · SLAS DISCOVERY · 12
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Variable selection and specification of robust QSAR models from multicollinear data: arylpiperazinyl derivatives with affinity and selectivity for ?2-adrenoceptors
2004 · D. W. Salt, L. Maccari, et al. · Journal of Computer-Aided Molecular Design · 11
Targeting DDX3X Helicase Activity with BA103 Shows Promising Therapeutic Effects in Preclinical Glioblastoma Models
2021 · Annalaura Brai, Valentina Riva, et al. · Cancers · 10
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Works count: 42
Citation count: 881
H-index: 18
I10-index: 26
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