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Simone V. Bigi-Botterill

Observed names: Simone Bigi, Simone V. Bigi
ORCID: 0000-0003-1309-2314
Observed ORCID: 0000-0003-1309-2314
OpenAlex ID: A5027477082
Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H -pyrazolo[3,4- c ]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships
2018 · Masato Yoshikawa, Morihisa Saitoh, et al. · Journal of Medicinal Chemistry · 130
Synthetic Approaches to the New Drugs Approved during 2019
2021 · Andrew C. Flick, Carolyn A. Leverett, et al. · Journal of Medicinal Chemistry · 55
Synthetic Approaches to the New Drugs Approved During 2020
2022 · Andrew C. Flick, Carolyn A. Leverett, et al. · Journal of Medicinal Chemistry · 46
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure
2017 · Marion Lanier, Jason Pickens, et al. · ACS Medicinal Chemistry Letters · 46
Fragment-based drug discovery of potent and selective MKK3/6 inhibitors
2015 · Mark Adams, Toshitake Kobayashi, et al. · Bioorganic & Medicinal Chemistry Letters · 30
Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3 character and an exquisite selectivity profile
2020 · Simone V. Bigi-Botterill, Anthony Ivetac, et al. · Bioorganic & Medicinal Chemistry Letters · 12
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Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1
2024 · Mark Sabat, Daniel W. Carney, et al. · Journal of Medicinal Chemistry · 4
Structural Biology in Drug Discovery and Development: Call for Papers
2024 · David E. Heppner, Simone V. Bigi-Botterill, et al. · Journal of Medicinal Chemistry · 3
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Structural Biology Enabling Drug Discovery
2025 · David E. Heppner, Simone V. Bigi-Botterill, et al. · Journal of Medicinal Chemistry · 2
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Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure”
2017 · Marion Lanier, Jason Pickens, et al. · ACS Medicinal Chemistry Letters · 2
Angiotensin II Receptor Antagonists with Carboxylic Functionalities in Cardiovascular Disease
2016 · Steve Swann, Simone Bigi · Wiley-VCH eBooks · 2
Structural Biology in Drug Discovery and Development: Call for Papers
2024 · David E. Heppner, Simone V. Bigi-Botterill, et al. · ACS Medicinal Chemistry Letters · 1
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Fifteen Years, One Mission: Innovative, Inspirational, and Impactful Discoveries
2025 · Simone V. Bigi-Botterill, Chiara Borsari, et al. · ACS Medicinal Chemistry Letters
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In this Issue Volume 16, Issue 6
2025 · Simone V. Bigi-Botterill · ACS Medicinal Chemistry Letters
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In This Issue, Volume 15, Issue 10
2024 · Simone V. Bigi-Botterill · ACS Medicinal Chemistry Letters
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Announcing the Early Career Board of ACS Medicinal Chemistry Letters
2024 · Aleksandra Baranczak, Simone V. Bigi-Botterill, et al. · ACS Medicinal Chemistry Letters
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Exploiting unique interactions in the MKK3/6 and ASK1 kinase active sites through computer- aided drug design
2017 · Simone V. Bigi
Works count: 17
Citation count: 333
H-index: 6
I10-index: 6
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