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Simone Pellegrino

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
2021 · Kaosheng Lv, Chujie Gong, et al. · Cell stem cell · 88
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The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth
2018 · Simone Pellegrino, Mélanie Meyer, et al. · Structure · 73
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Mechanism of completion of peptidyltransferase centre assembly in eukaryotes
2019 · Vasileios Kargas, Pablo Castro-Hartmann, et al. · eLife · 64
Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance
2018 · Simone Pellegrino, Natalia Demeshkina, et al. · Journal of Molecular Biology · 62
Structural and Functional Characterization of an SMC-like Protein RecN: New Insights into Double-Strand Break Repair
2012 · Simone Pellegrino, Jens Radzimanowski, et al. · Structure · 55
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Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
2020 · Iskander Khusainov, Bulat Fatkhullin, et al. · Nature Communications · 53
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Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides
2017 · Zef A. Könst, Anne R. Szklarski, et al. · Nature Chemistry · 49
Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A
2017 · Brandon McClary, Boris Zinshteyn, et al. · Cell chemical biology · 48
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A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
2022 · Pedro Rebelo-Guiomar, Simone Pellegrino, et al. · Nature Communications · 47
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Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution
2023 · Simone Pellegrino, Kyle C Dent, et al. · Nucleic Acids Research · 35
Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles
2025 · Michael E Østergaard, Michele Carrer, et al. · Nucleic Acids Research · 34
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Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome
2019 · Simone Pellegrino, Mélanie Meyer, et al. · Nucleic Acids Research · 22
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Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective
2021 · Simone Pellegrino, Salvatore Terrosu, et al. · Cancers · 20
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The chemical landscape of the human ribosome at 1.67 Å resolution
2023 · Alexandre Faille, Kyle C. Dent, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 19
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Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2
2023 · Maximilian A. J. Harman, Steven J. Stanway, et al. · Journal of Medicinal Chemistry · 13
Eukaryotic Ribosome as a Target for Cardiovascular Disease
2016 · Simone Pellegrino, Gulnara Yusupova · Cell chemical biology · 7
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Expression, purification and preliminary structural analysis of the head domain ofDeinococcus radioduransRecN
2011 · Simone Pellegrino, Jens Radzimanowski, et al. · Acta Crystallographica Section F Structural Biology and Crystallization Communications · 7
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Expression, purification and preliminary structural analysis of the coiled-coil domain ofDeinococcus radioduransRecN
2012 · Simone Pellegrino, Daniele de Sanctis, et al. · Acta Crystallographica Section F Structural Biology and Crystallization Communications · 5
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High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM
2025 · Shenaz Allyjaun, Emily Dunbar, et al. · Journal of Medicinal Chemistry · 2
Author response: Mechanism of completion of peptidyltransferase centre assembly in eukaryotes
2019 · Vasileios Kargas, Pablo Castro-Hartmann, et al. · eLife · 1
Gold-standard local validation enhances interpretability of cryo-EM maps
2025 · Vargas, Javier, Florea, Andreea V., et al. · Zenodo (CERN European Organization for Nuclear Research)
Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings
2025 · Maximilian A. J. Harman, Katherine U. Gaynor, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Bicycle Radionuclide Conjugates (BRCs) as agents for tumour targeting
2024 · Anusha Regupathy, Ben Blakeman, et al. · European Peptide Symposium (EPS)
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Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4
2021 · P. Rebelo-Guiomar, S. Pellegrino, et al. · Worldwide Protein Data Bank
Cryo-EM structure of 50S-RsfS complex from Staphylococcus aureus
2019 · I. Khusainov, S. Pellegrino, et al. · Worldwide Protein Data Bank
Works count: 42
Citation count: 704
H-index: 14
I10-index: 15
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