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Simonetta Maria Leto

Observed names: Simonetta Leto, Simonetta M. Leto
ORCID: 0000-0001-7580-6584
Observed ORCID: 0000-0001-7580-6584
OpenAlex ID: A5028066178
Effective drug combinations in breast, colon and pancreatic cancer cells
2022 · Patricia Jaaks, Elizabeth A. Coker, et al. · Nature · 483
HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment
2015 · Shyam M. Kavuri, Naveen Jain, et al. · Cancer Discovery · 318
IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies
2015 · Eugenia R. Zanella, Francesco Galimi, et al. · Science Translational Medicine · 128
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Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2 -Amplified Gastrointestinal Carcinomas
2015 · Simonetta M. Leto, Francesco Sassi, et al. · Clinical Cancer Research · 104
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Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies
2014 · Simonetta M. Leto, Livio Trusolino · Journal of Molecular Medicine · 92
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Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer
2021 · Giulia Rizzo, Andrea Bertotti, et al. · Journal of Experimental & Clinical Cancer Research · 59
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Preclinical efficacy of a HER2 synNotch/CEA-CAR combinatorial immunotherapy against colorectal cancer with HER2 amplification
2024 · Marco Cortese, Erica Torchiaro, et al. · Molecular Therapy · 35
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer
2023 · Simonetta M. Leto, Martina Ferri, et al. · Clinical Cancer Research · 29
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XENTURION is a population-level multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients
2024 · Simonetta M. Leto, Elena Grassi, et al. · Nature Communications · 24
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The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2025 · Marco Avolio, Simonetta M. Leto, et al. · Cancer Discovery · 9
Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)
2023 · Marta Falcinelli, Giulia Dell’Omo, et al. · Cell Death and Disease · 5
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Resistance of Colorectal Tumors to Anti-EGFR Antibodies
2018 · Livio Trusolino, Simonetta M. Leto · Resistance to targeted anti-cancer therapeutics · 2
Efficacy of dual KRASG12D–EGFR blockade versus triple combinations in patient-derived models of KRASG12D-mutant colorectal cancer
2026 · Simonetta M. Leto, Francesco Sassi, et al. · Cell Death and Disease · 1
213 Design, characterization and preclinical validation of a combinatorial CAR-based immunotherapy against colorectal cancer with HER2 amplification
2022 · Marco Cortese, Erica Torchiaro, et al. · Journal for ImmunoTherapy of Cancer · 1
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Supplementary Figure S9 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Figure S14 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Figure S4 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Table S3 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Figure S8 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Figure S2 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Table S6 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Figure S5 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Figure S12 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Figure S15 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Supplementary Table S7 from The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer
2026 · Marco Avolio, Simonetta M. Leto, et al.
Works count: 96
Citation count: 1,290
H-index: 9
I10-index: 9
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