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Mengqian Chen

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities
2012 · Donald C. Porter, Elena Farmaki, et al. · Proceedings of the National Academy of Sciences · 172
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CDK8/19 Mediator kinases potentiate induction of transcription by NFκB
2017 · Mengqian Chen, Jiaxin Liang, et al. · Proceedings of the National Academy of Sciences · 139
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer
2017 · Martina S.J. McDermott, Alexander A. Chumanevich, et al. · Oncotarget · 135
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CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases
2018 · Jiaxin Liang, Mengqian Chen, et al. · Cancer Research · 90
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer
2015 · Eugenia Broude, Balázs Gyorffy, et al. · Current Cancer Drug Targets · 89
Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells
2009 · Mengqian Chen, Matthew Tanner, et al. · Cell Cycle · 78
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins
2023 · Mengqian Chen, Jing Li, et al. · Nucleic Acids Research · 71
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A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia
2018 · Laixi Bi, Bin Zhou, et al. · BMC Cancer · 70
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The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase–Prostasin serine protease cascade in cultured epithelial cells
2007 · Mengqian Chen, Li-Mei Chen, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 61
Effects of Androgen Receptor and Androgen on Gene Expression in Prostate Stromal Fibroblasts and Paracrine Signaling to Prostate Cancer Cells
2011 · Matthew J. Tanner, R. Charles Welliver, et al. · PLoS ONE · 60
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Identifying Cancers Impacted by CDK8/19
2019 · Igor B. Roninson, Balázs Győrffy, et al. · Cells · 59
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Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance
2017 · Mannan Nouri, Josselin Caradec, et al. · Oncotarget · 59
Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells
2010 · Mengqian Chen, Michael A. Feuerstein, et al. · Molecular Cancer · 59
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Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition
2019 · Mengqian Chen, Jing Li, et al. · Cells · 57
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Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo
2022 · Xiaokai Ding, Amanda C. Sharko, et al. · Proceedings of the National Academy of Sciences · 48
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen
2017 · David Oliver, Hao Ji, et al. · Scientific Reports · 44
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The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor
2012 · Hongbo Wang, Ming Jiang, et al. · Molecular and Cellular Biology · 43
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Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor
2009 · Mengqian Chen, Li-Mei Chen, et al. · Molecular and Cellular Biochemistry · 43
De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer
2022 · Daochuan He, Mengqian Chen, et al. · Cancer Letters · 42
A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics
2022 · Li Zhang, Chen Cheng, et al. · Journal of Medicinal Chemistry · 40
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The hedgehog/Gli signaling paradigm in prostate cancer
2011 · Mengqian Chen, Richard Carkner, et al. · Expert Review of Endocrinology & Metabolism · 40
Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation
2006 · Li-Mei Chen, Cindy Wang, et al. · American Journal of Physiology-Renal Physiology · 36
Gli2 Expression and Human Bladder Transitional Carcinoma Cell Invasiveness
2010 · Clay W. Mechlin, Matthew J. Tanner, et al. · The Journal of Urology · 35
Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3
2007 · Mengqian Chen, Ya-Yuan Fu, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 35
Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG
2006 · Mengqian Chen, Li-Mei Chen, et al. · The Prostate · 33
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Works count: 107
Citation count: 1,850
H-index: 25
I10-index: 33
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