Author

Lizzy S. Kappen

Observed names: L S Kappen, L. S. KAPPEN, L. S. Kappen, L.S. Kappen, Lizzy Kappen

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), Northeastern University, Harvard University, University of Houston, University at Buffalo, State University of New York

OpenAlex ID: A5028143284

Roles of chromophore and apo-protein in neocarzinostatin action.

1980 · L S Kappen, M A Napier, et al. · Proceedings of the National Academy of Sciences · 110

Strand-scission of DNA by neocarzinostatin, auromomycin, and bleomycin: studies on base release and nucleotide sequence specificity

1981 · Masaru Takeshita, Lizzy S. Kappen, et al. · Biochemistry · 109

Deoxyribonucleic acid damage by neocarzinostatin chromophore: strand breaks generated by selective oxidation of C-5' of deoxyribose

1983 · Lizzy S. Kappen, Irving H. Goldberg · Biochemistry · 105

Identification of 2-deoxyribonolactone at the site of neocarzinostatin-induced cytosine release in the sequence d(AGC)

1989 · Lizzy S. Kappen, Irving H. Goldberg · Biochemistry · 91

DNA Conformation-Induced Activation of an Enediyne for Site-Specific Cleavage

1993 · Lizzy S. Kappen, Irving H. Goldberg · Science · 77

Activation and inactivation of neocarzinostatin-induced cleavage of DNA

1978 · Lizzy S. Kappen, Irving H. Goldberg · Nucleic Acids Research · 71

Activation of neocarzinostatin chromophore and formation of nascent DNA damage do not require molecular oxygen

1985 · Lizzy S. Kappen, H.Goldberg Irving · Nucleic Acids Research · 70

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Stabilization of neocarzinostatin nonprotein chromophore activity by interaction with apoprotein and with HeLa cells

1980 · Lizzy S. Kappen, Irving H. Goldberg · Biochemistry · 70

Isotope effects on the sequence-specific cleavage of DNA by neocarzinostatin: kinetic partitioning between 4'- and 5'-hydrogen abstraction at unique thymidine sites

1991 · Bruce L. Frank, Leroy Worth, et al. · Journal of the American Chemical Society · 66

Neocarzinostatin-induced hydrogen atom abstraction from C-4' and C-5' of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects

1991 · Lizzy S. Kappen, Irving H. Goldberg, et al. · Biochemistry · 62

Identification of thymidine-5′-aldehyde at DNA strand breaks induced by neocarzinostatin chromophore

1982 · Lizzy S. Kappen, Irving H. Goldberg, et al. · Proceedings of the National Academy of Sciences · 62

Atypical abasic sites generated by neocarzinostatin at sequence-specific cytidylate residues in oligodeoxynucleotides

1988 · Lizzy S. Kappen, Changqing Chen, et al. · Biochemistry · 60

Gaps in DNA induced by neocarzinostatin bear 3'- and 5'-phosphoryl termini

1978 · Lizzy S. Kappen, Irving H. Goldberg · Biochemistry · 57

Isotope effects on the sequence-specific cleavage of dC in d(AGC) sequences by neocarzinostatin: elucidation of chemistry of minor lesions

1990 · Lizzy S. Kappen, Irving H. Goldberg, et al. · Journal of the American Chemical Society · 49

Effect of nonprotein chromophore removal on neocarzinostatin action

1980 · Mary A. Napier, Lizzy S. Kappen, et al. · Biochemistry · 49

Mechanism and base specificity of DNA breakage in intact cells by neocarzinostatin

1987 · Lizzy S. Kappen, Thomas E. Ellenberger, et al. · Biochemistry · 46

3'-Formyl phosphate-ended DNA: high-energy intermediate in antibiotic-induced DNA sugar damage.

1987 · D H Chin, L S Kappen, et al. · Proceedings of the National Academy of Sciences · 45

Requirement for reducing agents in deoxyribonucleic acid strand scission by the purified chromophore of auromomycin

1980 · Lizzy S. Kappen, Mary A. Napier, et al. · Biochemistry · 39

Inhibition of Reticulocyte Peptide-Chain Initiation by Pactamycin: Accumulation of Inactive Ribosomal Initiation Complexes

1973 · Lizzy S. Kappen, Hideo Suzuki, et al. · Proceedings of the National Academy of Sciences · 34

Nitroaromatic radiation sensitizers substitute for oxygen in neocarzinostatin-induced DNA damage.

1984 · L S Kappen, I H Goldberg · Proceedings of the National Academy of Sciences · 32

Site-specific cleavage at a DNA bulge by neocarzinostatin chromophore via a novel mechanism

1993 · Lizzy S. Kappen, Irving H. Goldberg · Biochemistry · 30

Mechanism of the effect of organic solvents and other protein denaturants on neocarzinostatin activity

1979 · Lizzy S. Kappen, Irving H. Goldberg · Biochemistry · 29

Convenient Synthesis of NCS−Chromophore Metabolite Isosteres: Binding Agents for Bulged DNA Microenvironments

2004 · Yiqing Lin, Graham B. Jones, et al. · Organic Letters · 28

Contrasts in the actions of protein antibiotics on deoxyribonucleic acid structure and function

1979 · Lizzy S. Kappen, Irving H. Goldberg, et al. · Biochemistry · 28

Neocarzinostatin acts as a sensitive probe of DNA microheterogeneity: switching of chemistry from C-1' to C-4' by a G.T mismatch 5' to the site of DNA damage.

1992 · L S Kappen, I H Goldberg · Proceedings of the National Academy of Sciences · 27

Works count: 60

Citation count: 1,859

H-index: 26

I10-index: 43