Author

Defen Lu

Institution: Shanxi Agricultural University

Observed institutions: Shanxi Agricultural University, Fujian Medical University, Shandong University, Chinese Academy of Sciences, Mengchao Hepatobiliary Hospital, Institute of Microbiology, State Key Laboratory of Microbial Technology, The University of Texas Southwestern Medical Center, Tsinghua University

ORCID: 0000-0002-6154-0364

Observed ORCID: 0000-0002-6154-0364

OpenAlex ID: A5028900238

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

2012 · Guijun Shang, Deyu Zhu, et al. · Nature Structural & Molecular Biology · 244

Activation of STING by targeting a pocket in the transmembrane domain

2022 · Defen Lu, Guijun Shang, et al. · Nature · 203

Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression

2009 · Yongxin Zou, Jun Mi, et al. · Journal of Biological Chemistry · 129

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A conserved ion channel function of STING mediates noncanonical autophagy and cell death

2024 · Jinrui Xun, Zhichao Zhang, et al. · EMBO Reports · 122

The mechanism of STING autoinhibition and activation

2023 · Sheng Liu, Bo Yang, et al. · Molecular Cell · 104

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Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates

2014 · Deyu Zhu, Lijun Wang, et al. · Molecular Cell · 71

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Activation of STING Based on Its Structural Features

2022 · Behzad Hussain, Yufeng Xie, et al. · Frontiers in Immunology · 61

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Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

2021 · Defen Lu, Guijun Shang, et al. · Nature Communications · 59

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Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State

2012 · Wei Cheng, Kun Yin, et al. · PLoS Pathogens · 59

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Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

2017 · Guijun Shang, Chad A Brautigam, et al. · eLife · 56

Cullin 4B Protein Ubiquitin Ligase Targets Peroxiredoxin III for Degradation

2011 · Xi Li, Defen Lu, et al. · Journal of Biological Chemistry · 51

The structural basis of the Tle4–Tli4 complex reveals the self-protection mechanism of H2-T6SS inPseudomonas aeruginosa

2014 · Defen Lu, Youshi Zheng, et al. · Acta Crystallographica Section D Biological Crystallography · 44

Structural insights into the T 6 SS effector protein Tse 3 and the Tse 3– Tsi 3 complex from P seudomonas aeruginosa reveal a calcium‐dependent membrane‐binding mechanism

2014 · Defen Lu, Guijun Shang, et al. · Molecular Microbiology · 39

Crystal structures of porcine STINGCBD–CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins

2019 · Xiaoyan Cong, Zenglin Yuan, et al. · Journal of Biological Chemistry · 36

cGAS-STING: mechanisms and therapeutic opportunities

2025 · Mengyuan Zhang, Changxin Wu, et al. · Science China Life Sciences · 31

Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function

2012 · Guijun Shang, Xiuhua Liu, et al. · Biochemical Journal · 31

X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling

2013 · Fengjuan He, Defen Lu, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 23

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Structural and Functional Analyses of the FAM46C/Plk4 Complex

2020 · Hua Chen, Defen Lu, et al. · Structure · 22

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Molecular mechanism of phosphate import by the bacterial PstSCAB transporter

2026 · Hu Xiao, Shanqin Li, et al. · Nature Communications · 14

Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold

2023 · Shun Liu, Hua Chen, et al. · Science Advances · 14

Expression, purification and preliminary crystallographic analysis of the T6SS effector protein Tse3 fromPseudomonas aeruginosa

2013 · Defen Lu, Guijun Shang, et al. · Acta Crystallographica Section F Structural Biology and Crystallization Communications · 10

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An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy

2026 · Fang-Xu Li, Sheng Liu, et al. · Cell Insight · 4

Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation

2025 · Yuchao Yang, Yueyue Liu, et al. · mBio · 3

Structural plasticity of human leptin binding to its receptor LepR

2023 · Yufeng Xie, Xiaoxiong Li, et al. · hLife · 3

Structural mechanism of 3′3′-cGAMP-induced filamentation and phospholipid hydrolysis by CapV in bacterial antiphage defense