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Ryan J. Blackler

Observed names: R. J Blackler, R. J. Blackler, R.J. Blackler, Ryan Blackler, Ryan J Blackler
Institution: AbCellera (Canada)
ORCID: 0000-0002-2795-8337
Observed ORCID: 0000-0002-2795-8337
OpenAlex ID: A5028906387
Antibody recognition of carbohydrate epitopes
2015 · Omid Haji-Ghassemi, Ryan J Blackler, et al. · Glycobiology · 151
Structural basis of cell wall anchoring by SLH domains in Paenibacillus alvei
2018 · Ryan J. Blackler, Arturo López-Guzmán, et al. · Nature Communications · 46
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The role of CDR H3 in antibody recognition of a synthetic analog of a lipopolysaccharide antigen
2009 · C. L Brooks, R. J Blackler, et al. · Glycobiology · 23
Antigen binding by conformational selection in near-germline antibodies
2022 · Ryan J. Blackler, Sven Müller-Loennies, et al. · Journal of Biological Chemistry · 16
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A Common NH53K Mutation in the Combining Site of Antibodies Raised against Chlamydial LPS Glycoconjugates Significantly Increases Avidity
2011 · Ryan J. Blackler, Sven Müller-Loennies, et al. · Biochemistry · 14
Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments
2008 · Cory L. Brooks, Ryan J. Blackler, et al. · Acta Crystallographica Section D Biological Crystallography · 14
Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site
2016 · Ryan J Blackler, Susannah M L Gagnon, et al. · Glycobiology · 12
Antibody Recognition of Chlamydia LPS: Structural Insights of Inherited Immune Responses
2011 · Ryan J. Blackler, Sven Müller-Loennies, et al. · Springer eBooks · 12
Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishesN-glycan phosphorylation in a branch-specific manner
2015 · Ryan J Blackler, Dylan W Evans, et al. · Glycobiology · 9
pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in the formation of the semi-closed state
2013 · A. R. Johal, R. J. Blackler, et al. · Glycobiology · 9
Abstract 1788: Increasing the therapeutic index of IL12 by engineering for tumor specific protease activation
2021 · Jennifer Leah Bishop, Ryan Blackler, et al. · Cancer Research · 4
Abstract 2935: ZW270, a conditionally masked IL-12 cytokine fusion protein displaying potent anti-tumor activity absent systemic toxicity
2023 · Maya C. Poffenberger, Jennifer L. Bishop, et al. · Cancer Research · 2
Abstract 2373: Functional and specific T-cell engagers against a peptide-MHC tumor target
2024 · Davide Tortora, Peter Bergqvist, et al. · Cancer Research · 1
1291 Profiling bispecific T-cell engagers: strategies for enhancing potency while minimizing cytokine release
2024 · Peter Bergqvist, Amy Burke, et al. · Journal for ImmunoTherapy of Cancer
1395 Targeting intracellular tumor antigens to Figureht cancer: discovery and development of functional and specific T-cell engagers against a MAGE-A4 pMHC
2023 · Davide Tortora, Peter Bergqvist, et al. · Journal for ImmunoTherapy of Cancer
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Crystal structure of SpaA-SLH in complex with beta-D-GlcNAc-(1->3)-4,6-Pyr-beta-D-ManNAcOMe
2018 · R.J. Blackler, S.V. Evans · Worldwide Protein Data Bank
Crystal structure of SpaA-SLH
2018 · R.J. Blackler, S.V. Evans · Worldwide Protein Data Bank
Structural investigations into conformational diversity, polyspecificity, and binding mechanisms of near-germline antibodies
2016 · R.J. Blackler · UVic’s Research and Learning Repository (University of Victoria)
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GTA mutant with mercury - E303A
2015 · S.M.L. Gagnon, R.J. Blackler · Worldwide Protein Data Bank
Fv M6P-1 in complex with mannose-6-phosphate
2014 · R.J. Blackler, D.W. Evans, et al. · Worldwide Protein Data Bank
Crystal Structure of BBBB at pH 10.0 with MPD as the cryoprotectant
2013 · A.R. Johal, R.J. Blackler, et al. · Worldwide Protein Data Bank
Crystal Structure of ABBA+UDP+Gal at pH 8.0 with MPD as the cryoprotectant
2012 · A.R. Johal, J.A. Alfaro, et al. · Worldwide Protein Data Bank
Crystal Structure of AAAA+UDP+Gal at pH 5.0 with MPD as the cryoprotectant
2012 · A.R. Johal, J.A. Alfaro, et al. · Worldwide Protein Data Bank
Crystal structure of S25-39 in complex with Kdo(2.4)Kdo(2.4)Kdo
2010 · R.J. Blackler, S.V. Evans · Worldwide Protein Data Bank
Crystal structure of S25-39 in complex with Kdo(2.8)Kdo
2010 · R.J. Blackler, S.V. Evans · Worldwide Protein Data Bank
Works count: 42
Citation count: 313
H-index: 9
I10-index: 8
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