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Rebecca L. Brouillette

Observed names: Brouillette, Rebecca, Brouillette, Rebecca L., R. Brouillette, R.L. Brouillette, Rebecca Brouillette, Rebecca L Brouillette
ORCID: 0000-0002-5466-9653
Observed ORCID: 0000-0002-5466-9653
OpenAlex ID: A5029125656
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs
2019 · Aleksandra Luginina, Anastasiia Gusach, et al. · Science Advances · 107
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
2019 · Anastasiia Gusach, Aleksandra Luginina, et al. · Nature Communications · 74
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The signaling signature of the neurotensin type 1 receptor with endogenous ligands
2017 · Élie Besserer-Offroy, Rebecca L. Brouillette, et al. · European Journal of Pharmacology · 71
Structural insight into apelin receptor-G protein stoichiometry
2022 · Yang Yue, Lier Liu, et al. · Nature Structural & Molecular Biology · 65
Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR
2020 · Arman A. Sadybekov, Rebecca L. Brouillette, et al. · Biomolecules · 33
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Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8–13)
2018 · Marc Sousbie, Mélanie Vivancos, et al. · Journal of Medicinal Chemistry · 30
The P2Y6 receptor signals through Gαq/Ca2+/PKCα and Gα13/ROCK pathways to drive the formation of membrane protrusions and dictate cell migration
2020 · Mélissa Girard, Steve Dagenais Bellefeuille, et al. · Journal of Cellular Physiology · 22
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain
2020 · Rebecca L. Brouillette, Élie Besserer-Offroy, et al. · Pharmacological Research · 18
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Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog
2020 · Pascal Tétreault, Élie Besserer-Offroy, et al. · European Journal of Pharmacology · 14
In Search of the Optimal Macrocyclization Site for Neurotensin
2018 · Marc Sousbie, Élie Besserer-Offroy, et al. · ACS Medicinal Chemistry Letters · 12
Discovery of a CCR2-targeting pepducin therapy for chronic pain
2024 · Élora Midavaine, Rebecca L. Brouillette, et al. · Pharmacological Research · 11
Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail
2025 · Émile Breault, Rebecca L. Brouillette, et al. · CNS Drugs · 6
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Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics
2024 · Jolien De Neve, Émile Breault, et al. · ACS Pharmacology & Translational Science · 6
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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor
2025 · Rebecca L. Brouillette, Christine E. Mona, et al. · Pharmacological Research · 5
Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8–13) analog
2020 · Élie Besserer-Offroy, Pascal Tétreault, et al. · Data in Brief · 5
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Assessing Gαq/15-signaling with IP-One: Single Plate Transfection and Assay Protocol for Cell-Based High-Throughput Assay
2020 · Elie Besserer-Offroy, Rebecca Brouillette, et al. · BIO-PROTOCOL · 5
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Monitoring cell-surface expression of GPCR by ELISA v1
2019 · Elie Besserer-Offroy, Rebecca L Brouillette, et al. · 2
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A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function
2025 · Rebecca L. Brouillette, Frédérique Lussier, et al. · Acta Pharmaceutica Sinica B · 1
Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors
2025 · Marie-Edith Nepveu-Traversy, Malihe Hassanzadeh, et al. · Nature Communications · 1
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CCR2-targeting pepducins reduce T cell-nociceptor interaction driving bone cancer pain
2023 · Élora Midavaine, Rebecca L. Brouillette, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Opioid Analgesics: Rise and Fall of Ligand Biased Signalling anf Future Perspectives in the Quest for the Holy Grail
2024 · Philippe Sarret, Émile Breault, et al. · OSF Preprints (OSF Preprints)
Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog.
2020 · Besserer-Offroy, Élie, Tétreault, Pascal, et al. · Figshare
XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast
2019 · A. Luginina, A. Gusach, et al. · Worldwide Protein Data Bank
Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372
2019 · A. Gusach, A. Luginina, et al. · Worldwide Protein Data Bank
Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (C2221 space group)
2019 · A. Gusach, A. Luginina, et al. · Worldwide Protein Data Bank
Works count: 30
Citation count: 488
H-index: 11
I10-index: 11
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