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David Amantini

Observed names: Amantini, D., D Amantini, D. Amantini
Institution: Galapagos (France)
ORCID: 0000-0002-6758-1861
Observed ORCID: 0000-0002-6758-1861
OpenAlex ID: A5029640760
TBAF-Catalyzed Synthesis of 5-Substituted 1H-Tetrazoles under Solventless Conditions
2004 · David Amantini, Romina Beleggia, et al. · The Journal of Organic Chemistry · 278
Synthesis of 4-Aryl-1H-1,2,3-triazoles through TBAF-Catalyzed [3 + 2] Cycloaddition of 2-Aryl-1-nitroethenes with TMSN3 under Solvent-Free Conditions
2005 · David Amantini, Francesco Fringuelli, et al. · The Journal of Organic Chemistry · 144
Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists
2011 · Alessandro Gozzi, Giuliano Turrini, et al. · PLoS ONE · 106
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3-Nitrocoumarins as Dienophiles in the Diels−Alder Reaction in Water. An Approach to the Synthesis of Nitrotetrahydrobenzo[c]chromenones and Dihydrodibenzo[b,d]furans
2003 · David Amantini, Francesco Fringuelli, et al. · The Journal of Organic Chemistry · 78
Efficient O-Trimethylsilylation of Alcohols and Phenols with Trimethylsilyl Azide Catalyzed by Tetrabutylammonium Bromide under Neat Conditions
2001 · David Amantini, Francesco Fringuelli, et al. · The Journal of Organic Chemistry · 70
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis
2021 · Franck Brebion, Romain Gosmini, et al. · Journal of Medicinal Chemistry · 67
Water, a clean, inexpensive, and re-usable reaction medium. One-pot synthesis of (E)-2-aryl-1-cyano-1-nitroethenes
2001 · D. Amantini, F. Fringuelli, et al. · Green Chemistry · 57
Uncatalyzed [4 + 2] Cycloadditions of 3-Nitrocoumarins with Vinyl Ethers in Solventless Conditions. A New Entry to Chromene Derivatives
2002 · David Amantini, Francesco Fringuelli, et al. · The Journal of Organic Chemistry · 54
Bromolysis and Iodolysis of α,β-Epoxycarboxylic Acids in Water Catalyzed by Indium Halides
2001 · David Amantini, Francesco Fringuelli, et al. · The Journal of Organic Chemistry · 41
Selected Methods for the Reduction of the Azido Group
2002 · D. Amantini, F. Fringuelli, et al. · Organic Preparations and Procedures International · 38
Discovery and development of ASK1 inhibitors
2020 · Reginald Brys, Karl Gibson, et al. · Progress in medicinal chemistry · 32
Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5
2021 · P. Clement-Lacroix, C.B. Little, et al. · Osteoarthritis and Cartilage · 30
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases
2024 · Christophe Peixoto, Agnes Joncour, et al. · Journal of Medicinal Chemistry · 28
Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip
2021 · Ellen van der Aar, Henri Deckx, et al. · Clinical Pharmacology in Drug Development · 27
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Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312
2023 · Taouès Temal-Laib, Christophe Peixoto, et al. · Journal of Medicinal Chemistry · 24
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Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases
2024 · Oscar Mammoliti, Sébastien Martina, et al. · Journal of Medicinal Chemistry · 19
GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA
2017 · P. Clement-Lacroix, C. Little, et al. · Osteoarthritis and Cartilage · 17
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Nucleophilic ring opening of 1,2-epoxides in aqueous medium
2003 · David Amantini, Francesco Fringuelli, et al. · ARKIVOC · 17
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ADAMTS-5 inhibitor GLPG1972, a potential new treatment in osteoarthritis, shows favorable safety, pharmacokinetics and pharmacodynamics in healthy subjects
2018 · E.M. van der Aar, J. Desrivot, et al. · Osteoarthritis and Cartilage · 11
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Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally “frozen” analogues of L-glutamic acid
2014 · Beatrice Bechi, David Amantini, et al. · Beilstein Journal of Organic Chemistry · 10
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ZnCl2as an Efficient Catalyst in the Thiolysis of 1,2-Epoxides by Thiophenol in Aqueous Medium
2003 · Ferdinando Pizzo, Luigi Vaccaro, et al. · Synlett · 10
Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone
2012 · Liming Cao, John P. Maciejewski, et al. · Organic & Biomolecular Chemistry · 8
ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model
2018 · P. Clement-Lacroix, S. Meurisse, et al. · Osteoarthritis and Cartilage · 7
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Selective SIK2/SIK3 inhibition reprograms pro- and antiinflammatory pathways in myeloid cells, improving autoimmune disease outcomes
2026 · Steve De Vos, Nicolas Desroy, et al. · JCI Insight · 4
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Design of a potent and selective dual JAK1/TYK2 inhibitor
2024 · Oscar Mammoliti, Christel Menet, et al. · Bioorganic & Medicinal Chemistry · 4
Works count: 42
Citation count: 1,196
H-index: 17
I10-index: 21
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