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Author

Laurence H. Arnold

Observed names: L.H. Arnold, Laurence Arnold
Observed institutions: LifeArc, The Francis Crick Institute, Stevenage Bioscience Catalyst, Pelago Bioscience (Sweden), National Institute for Medical Research, Medical Research Council
ORCID: 0000-0001-6785-1035
Observed ORCID: 0000-0001-6785-1035
OpenAlex ID: A5029664781
Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction
2015 · Laurence H. Arnold, Harriet C. T. Groom, et al. · PLoS Pathogens · 108
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Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches
2017 · Patrick J. McIntyre, Patrick M. Collins, et al. · ACS Chemical Biology · 59
The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite
2011 · Laurence H. Arnold, Louise E. Butt, et al. · Journal of Biological Chemistry · 54
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Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis
2020 · Elizabeth R. Morris, Sarah J. Caswell, et al. · Nature Communications · 45
A Continuous Enzyme-Coupled Assay for Triphosphohydrolase Activity of HIV-1 Restriction Factor SAMHD1
2014 · Laurence H. Arnold, Simone Kunzelmann, et al. · Antimicrobial Agents and Chemotherapy · 45
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CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target
2020 · Tomas Friman, Alexey Chernobrovkin, et al. · SLAS DISCOVERY · 25
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High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ
2023 · Hannah Rowlands, Kirsten Tschapalda, et al. · SLAS DISCOVERY · 15
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Abstract 3162: New hit compounds for p53 identified with a CETSA based high throughput screen
2025 · Tomas Friman, Merve Kacal, et al. · Cancer Research
Abstract 1413: Dissecting the biology of mutant p53 with the Cellular Thermal Shift Assay (CETSA)
2025 · Tomas Friman, Merve Kacal, et al. · Cancer Research
Abstract 3097: CETSA HT: Employing rapid high-throughput target engagement technology in primary screening of P53
2024 · Merve Kacal, Tomas Friman, et al. · Cancer Research
Abstract 3096: CETSA Navigate HT: A new paradigm for high-throughput screening
2024 · Helena Almqvist, Victoria Brehmer, et al. · Cancer Research
Abstract 4723: Target engagement sheds light on difference in drug efficacy in breast cancer cell lines
2024 · Tomas Friman, Tuomas Tolvanen, et al. · Cancer Research
Works count: 17
Citation count: 351
H-index: 7
I10-index: 7
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