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Hélène Tran

Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons
2016 · Rodrigo Lopez-Gonzalez, Yubing Lu, et al. · Neuron · 432
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Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons
2013 · Sandra Almeida, Eduardo Gascon, et al. · Acta Neuropathologica · 334
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Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice
2015 · Owen M. Peters, Gabriela Toro Cabrera, et al. · Neuron · 280
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Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS
2015 · Helene Tran, Sandra Almeida, et al. · Neuron · 205
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Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide
2021 · Hélène Tran, Michael P. Moazami, et al. · Nature Medicine · 189
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Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy
2014 · Marie-Laure Caillet-Boudin, Francisco-Jose Fernandez-Gomez, et al. · Frontiers in Molecular Neuroscience · 108
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Analysis of Exonic Regions Involved in Nuclear Localization, Splicing Activity, and Dimerization of Muscleblind-like-1 Isoforms
2011 · Hélène Tran, Nathalie Gourrier, et al. · Journal of Biological Chemistry · 95
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Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
2022 · Cristian Arredondo, Carolina Cefaliello, et al. · Neuron · 91
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models
2021 · Yuanjing Liu, Jean-Cosme Dodart, et al. · Nature Communications · 82
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Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing
2011 · C.M. Dhaenens, H. Tran, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 78
Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: Two individual consequences of CUG trinucleotide repeats
2007 · C.M. Dhaenens, S. Schraen-Maschke, et al. · Experimental Neurology · 69
Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats
2022 · Ludovic Arandel, Magdalena Matloka, et al. · Nature Biomedical Engineering · 45
Clinical Applications of Antisense Oligonucleotides in Cancer: A Focus on Glioblastoma
2024 · Alexandre Khuu, Maïté Verreault, et al. · Cells · 25
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Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy
2026 · Tojo Nakayama, Christelle M. El Achkar, et al. · Nature Medicine · 20
Myotonic Dystrophy: an RNA Toxic Gain of Function Tauopathy?
2019 · Francisco Fernandez-Gomez, Helene Tran, et al. · Advances in experimental medicine and biology · 18
A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants
2017 · Chi-Hong Wu, Anthony Giampetruzzi, et al. · Human Molecular Genetics · 17
Altered splicing of Tau in DM1 is different from the foetal splicing process
2009 · Dana Ghanem, Hélène Tran, et al. · FEBS Letters · 13
Consensus Brain-derived Protein, Extraction Protocol for the Study of Human and Murine Brain Proteome Using Both 2D-DIGE and Mini 2DE Immunoblotting
2014 · Francisco-Jose Fernandez-Gomez, Fanny Jumeau, et al. · Journal of Visualized Experiments · 12
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Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo
2023 · Gabriela Toro Cabrera, Katharina E. Meijboom, et al. · Gene Therapy · 11
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Voltage-Gated Ion Channel Compensatory Effect in DEE: Implications for Future Therapies
2024 · Khadijeh Shabani, Johannes Krupp, et al. · Cells · 8
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Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs
2024 · James W. Gilbert, Zachary Kennedy, et al. · Molecular Therapy — Nucleic Acids · 8
O4‐05‐02: the Investigational Stereopure Antisense Oligonucleotide Wve‐3972‐01 Preferentially Reduces G4c2 Repeat‐containing C9orf72 Transcripts: a Potential Therapeutic Approach for the Treatment of Frontotemporal Dementia
2018 · Jean-Cosme Dodart, Yuanjing Liu, et al. · Alzheimer s & Dementia
Stereopure Antisense Oligonucleotides Preferentially Knockdown G4C2 Repeat-Containing C9ORF72 Transcripts: A Potential Therapeutic Approach for the Treatment of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) (N2.002)
2018 · Yuanjing Liu, Jean-Cosme Dodart, et al. · Neurology
Erratum to: Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons
2014 · Sandra Almeida, Eduardo Gascon, et al. · Acta Neuropathologica
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P3‐120: Mis‐splicing of Tau Exon 2 and Exon 10 in myotonic dystrophy brain would result from different mechanisms
2011 · Marie‐Laure Caillet‐Boudin, Claire‐Marie Dhaenens, et al. · Alzheimer s & Dementia
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Works count: 25
Citation count: 2,140
H-index: 16
I10-index: 19
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