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Margarida Espadinha

Observed name: Espadinha, Margarida
Institution: BOS (Germany)
ORCID: 0000-0002-7053-0475
Observed ORCID: 0000-0002-7053-0475
OpenAlex ID: A5030476450
An Update on MDMX and Dual MDM2/X Inhibitors
2018 · Margarida Espadinha, Valentina Barcherini, et al. · Current Topics in Medicinal Chemistry · 49
DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties
2017 · Joana Soares, Margarida Espadinha, et al. · Molecular Oncology · 48
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Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors
2022 · Margarida Espadinha, Elizabeth A. Lopes, et al. · European Journal of Medicinal Chemistry · 46
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Improving anticancer activity towards colon cancer cells with a new p53‐activating agent
2018 · Liliana Raimundo, Margarida Espadinha, et al. · British Journal of Pharmacology · 26
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Novel squaramides with in vitro liver stage antiplasmodial activity
2016 · Carlos J.A. Ribeiro, Margarida Espadinha, et al. · Bioorganic & Medicinal Chemistry · 21
Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line
2020 · Luís R. Raposo, Ana Silva, et al. · Bioorganic & Medicinal Chemistry · 19
Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin
2023 · Siham Benramdane, Joni De Loose, et al. · Journal of Medicinal Chemistry · 17
Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis
2015 · Maria Perez, Margarida Espadinha, et al. · Current Pharmaceutical Design · 15
Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells
2023 · Gábor Girst, Elizabeth A. Lopes, et al. · RSC Medicinal Chemistry · 9
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Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists
2017 · Margarida Espadinha, Jorge Dourado, et al. · ChemMedChem · 8
Active site-directed probes targeting dipeptidyl peptidases 8 and 9
2024 · Margarida Espadinha, Joni De Loose, et al. · European Journal of Medicinal Chemistry · 5
Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma
2021 · Margarida Espadinha, Valentina Barcherini, et al. · Pharmaceuticals · 5
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Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders
2020 · Margarida Espadinha, Lucía Viejo, et al. · European Journal of Medicinal Chemistry · 5
PPIs as therapeutic targets for anticancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors
2020 · Margarida Espadinha, Stuart J. Conway, et al. · Elsevier eBooks · 2
Tryptophanol-derived oxazoloisoindolinone fluorescent probes for cellular localization studies of p53 activators
2024 · Hélio L. Barros, Margarida Espadinha, et al. · Bioorganic Chemistry · 1
Designing novel spiropyrazoline oxindoles to dual target p53-MDM2/X PPIs
2023 · Elizabeth A. Lopes, Margarida Espadinha, et al. · 1
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Abstract 1699: GlycoConnect© ADC toolbox expansion with dual payload ADC (dpADC) technology
2026 · Remon van Geel, Lieke Kraaijvanger, et al. · Cancer Research
Abstract 1682: Potency-Attenuated analogues of PNU-159,682 in conjugation with GlycoConnect® and HydraSpace® technologies provide ADCs with improved tolerability and efficacy
2026 · Marcel Scheepstra, Remon van Geel, et al. · Cancer Research
Selective and Orally Bioavailable Dipeptidyl Peptidase 9 Inhibitors with Potent Pyroptosis Induction Properties
2025 · Nicolò Filippi, Kathleen Mertens, et al. · Journal of Medicinal Chemistry
Protoflavone – spirooxindole hybrids exhibit promising, increased antitumor activity
2021 · Gábor Girst, ElizabethA Lopes, et al. · Planta Medica
CCDC 1977402: Experimental Crystal Structure Determination
2020 · Espadinha, Margarida, Viejo, Lucía, et al. · The Cambridge Structural Database
CCDC 1977401: Experimental Crystal Structure Determination
2020 · Espadinha, Margarida, Viejo, Lucía, et al. · The Cambridge Structural Database
Contributors
2020 · Michelle R. Arkin, Andrea Basso, et al. · Elsevier eBooks
Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity
2019 · Maria Santos, Valentina Barcherini, et al. · International Electronic Conference on Medicinal Chemistry (ECMC)
Enhancing anticancer activity of spiropyrazoline oxindoles by disrupting p53-MDMs PPIs
2019 · Maria Santos, Elizabeth Lopes, et al. · International Electronic Conference on Medicinal Chemistry (ECMC)
Works count: 35
Citation count: 277
H-index: 9
I10-index: 8
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