Author

Jun Kunitomo

Observed names: J. KUNITOMO, J. Kunitomo, Kunitomo, J., Kunitomo, J.-I., Kunitomo, Jun

Observed institutions: Mukogawa Women's University, Wayne State University, Kyoto University, Kobe Gakuin University, Kyoto University Institute for Chemical Research, Takeda (Japan), The University of Osaka

ORCID: 0000-0002-9999-8151

Observed ORCID: 0000-0002-9999-8151

OpenAlex ID: A5031002036

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

2009 · Morihisa Saitoh, Jun Kunitomo, et al. · Journal of Medicinal Chemistry · 130

Design, synthesis and structure–activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β

2009 · Morihisa Saitoh, Jun Kunitomo, et al. · Bioorganic & Medicinal Chemistry · 113

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(S )‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

2011 · Tomohiro Onishi, Hiroki Iwashita, et al. · Journal of Neurochemistry · 91

Discovery of 1-[2-Fluoro-4-(1 H -pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1 H -pyrazol-5-yl)pyridazin-4(1 H )-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

2014 · Jun Kunitomo, Masato Yoshikawa, et al. · Journal of Medicinal Chemistry · 64

Alkaloids of Nelumbo nucifera

1973 · J. Kunitomo, Y. Yoshikawa, et al. · Phytochemistry · 38

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor

2015 · Masato Yoshikawa, Haruhi Kamisaki, et al. · Bioorganic & Medicinal Chemistry · 34

Atropisomeric Flavoenzyme Models with a Modified Pyrimidine Ring: Syntheses, Physical Properties, and Stereochemistry in the Reactions with NAD(P)H Analogs

1996 · Atsuyoshi Ohno, Jun Kunitomo, et al. · The Journal of Organic Chemistry · 31

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists

2011 · Tatsuhiko Fujimoto, Jun Kunitomo, et al. · Bioorganic & Medicinal Chemistry Letters · 28

Structure and synthesis of menisporphine, a new type of isoquinoline alkaloid

1983 · J. Kunitomo, M. Satoh, et al. · Tetrahedron · 26

Imenine, a ring-B substituted aporphine alkaloid

1969 · M. D. Glick, R. E. Cook, et al. · Journal of the Chemical Society D Chemical Communications · 21

Synthesis, Structure–Activity Relationship, and Pharmacological Studies of Novel Melanin-Concentrating Hormone Receptor 1 Antagonists 3-Aminomethylquinolines: Reducing Human Ether-a-go-go-Related Gene (hERG) Associated Liabilities

2012 · Shizuo Kasai, Makoto Kamata, et al. · Journal of Medicinal Chemistry · 19

Constitution of three new alkaloids, aknadinine (4-demethylhasubanonine), aknadicine (4-demethylnorhasubanonine), and aknadilactam (4-demethyl-16-oxohasubanonine)

1970 · B.K. Moza, B. Bhaburi, et al. · Tetrahedron · 17

Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists

2011 · Tatsuhiko Fujimoto, Yoshihide Tomata, et al. · Bioorganic & Medicinal Chemistry Letters · 16

First example of “diastereotopic face activation” and chiral recognition without metal assistance. A novel 5-deazaflavin enzyme model.

1992 · Tetsuji Kawamoto, Masaki Tomishima, et al. · Tetrahedron Letters · 14

Structure of nandazurine, fromNandina domestica thumb

1973 · J. Kunitomo, M. Ju-ichi, et al. · Cellular and Molecular Life Sciences · 10

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket

2016 · Masato Yoshikawa, Takenori Hitaka, et al. · Bioorganic & Medicinal Chemistry · 9

The alkaloids of Chondodendron toxicoferum

1969 · M.P. Cava, J. Kunitomo, et al. · Phytochemistry · 9

Enantioselective Synthesis of the Novel Chiral Sulfoxide Derivative as a Glycogen Synthase Kinase 3.BETA. Inhibitor

2010 · Morihisa Saitoh, Jun Kunitomo, et al. · Chemical and Pharmaceutical Bulletin · 6

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Physical properties of atropisomeric 5-deazaflavin derivatives

1997 · Atsuyoshi Ohno, Jun Kunitomo, et al. · Tetrahedron · 6

Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes

2017 · Yoshihiro Banno, Shigekazu Sasaki, et al. · Bioorganic & Medicinal Chemistry · 5

ChemInform Abstract: STUDIES ON THE ALKALOIDS OF MENISPERMACEOUS PLANTS. 279. ALKALOIDS OF MENISPERMUM DAURICUM DC. 9. STRUCTURE AND SYNTHESIS OF MENISPORPHINE, A NEW TYPE OF ISOQUINOLINE ALKALOID

1984 · J. KUNITOMO, M. SATOH, et al. · ChemInform · 5

Variation of reaction channel in a flavoenzyme model with a modified pyrimidine ring

1994 · Atsuyoshi Ohno, Jun Kunitomo, et al. · Tetrahedron Letters · 4

Geometrical change of a flavoenzyme model through hydrogen bonding to the pyrimidine ring

1996 · Yasushi Kawai, Jun Kunitomo, et al. · Tetrahedron Letters · 3

In vitro clastogenicity of the aporphine-type alkaloids

1991 · S. Tadaki, T. Nozaka, et al. · Mutation Research/Environmental Mutagenesis and Related Subjects · 3

First Determination of the Absolute Configuration of an Atropisomeric Flavin Derivative

1998 · Y. Kawai, J. Kunitomo, et al. · Acta Crystallographica Section C Crystal Structure Communications · 2

Works count: 57

Citation count: 708

H-index: 14

I10-index: 15