Author

Kenji Tai

Observed names: K. TAI, K. Tai, Kenji TAI

Observed institutions: Hokkaido University, Eisai (Japan)

OpenAlex ID: A5031438140

E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities

2009 · Masaki Goto, Jesse Chow, et al. · Journal of Pharmacology and Experimental Therapeutics · 54

Syntheses and Structure−Activity Relationships of 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline Derivatives with Retinoic Acid Receptor α Agonistic Activity

2000 · Kouichi Kikuchi, Shigeki Hibi, et al. · Journal of Medicinal Chemistry · 44

Discovery of Novel and Potent Retinoic Acid Receptor α Agonists: Syntheses and Evaluation of Benzofuranyl-pyrrole and Benzothiophenyl-pyrrole Derivatives

2000 · Hiroyuki Yoshimura, Kouichi Kikuchi, et al. · Journal of Medicinal Chemistry · 31

Syntheses and Structure−Activity Relationships of Novel Retinoid X Receptor Agonists

1998 · Shigeki Hibi, Kouichi Kikuchi, et al. · Journal of Medicinal Chemistry · 27

Plasma biomarkers for early detection of alzheimer’s disease: a cross-sectional study in a Japanese cohort

2025 · Masahito Kubota, Shogyoku Bun, et al. · Alzheimer s Research & Therapy · 25

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Mutagenesis of the fourth calcium-binding domain of yeast calmodulin

1993 · I. Matsuura, E. Kimura, et al. · Journal of Biological Chemistry · 23

2020 · Daisuke Shintani, Taro Hihara, et al. · International Journal of Gynecological Cancer · 22

Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists

2001 · Kouichi Kikuchi, Katsuya Tagami, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Evaluation of circulating tumor DNA in patients with ovarian cancer harboring somatic PIK3CA or KRAS mutations

2017 · A. Ogasawara, T. Hihara, et al. · Annals of Oncology · 18

Evaluation of Circulating Tumor DNA in Patients with Ovarian Cancer Harboring Somatic PIK3CA or KRAS Mutations

2020 · Aiko Ogasawara, Taro Hihara, et al. · Cancer Research and Treatment · 16

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Structure-Based Development of a Protein–Protein Interaction Inhibitor Targeting Tumor Necrosis Factor Receptor-Associated Factor 6

2015 · Jun Moriya, Koh Takeuchi, et al. · Journal of Medicinal Chemistry · 14

Novel retinoic acid receptor α agonists: syntheses and evaluation of pyrazole derivatives

2000 · Kouichi Kikuchi, Shigeki Hibi, et al. · Bioorganic & Medicinal Chemistry Letters · 12

Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrolyl-benzoic acids as potent and selective retinoic acid receptor α agonists

2000 · Shigeki Hibi, Katsuya Tagami, et al. · Bioorganic & Medicinal Chemistry Letters · 8

Existence of Retinoic Acid-Receptor-Independent Retinoid X-Receptor-Dependent Pathway in Myeloid Cell Function

2001 · Takayuki Hida, Kenji Tai, et al. · The Japanese Journal of Pharmacology · 7

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Abstract 3264: Lenvatinib in combination with everolimus demonstrated enhanced antiangiogenesis and antitumor activity in human RCC xenograft models

2016 · Yusuke Adachi, Masahiro Matsuki, et al. · Cancer Research · 3

ChemInform Abstract: Syntheses and Structure—Activity Relationships of 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethyl‐2‐quinoxaline Derivatives with Retinoic Acid Receptor α Agonistic Activity.

2000 · Kouichi Kikuchi, Shigeki Hibi, et al. · ChemInform · 2

Biomarkers, Cognitive Function, and Mortality in Centenarians

2026 · Ryo Shikimoto, Takashi Sasaki, et al. · JAMA Network Open · 1

Development of a Japanese polygenic risk score model for amyloid-β PET imaging in Alzheimer’s disease

2025 · Misato Kaishima, Junichi Ito, et al. · Alzheimer s Research & Therapy · 1

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The antitumor activity of lenvatinib (LEN) in combination with everolimus (EVE) in human renal cell carcinoma (RCC) xenograft models is dependent on VEGFR and FGFR signaling

2016 · T. Kimura, Y. Adachi, et al. · Annals of Oncology · 1

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Abstract 3262: Effects of lenvatinib mesilate in combination with everolimus on VEGF and FGF-driven angiogenesis and tumor growth

2016 · Kaoru Mitsuhashi, Takayuki Kimura, et al. · Cancer Research · 1

The C-terminal Half-molecular Domain of Calmodulin is Responsible for High-affinity Interaction with Target Enzymes.

1995 · Eishu KIMURA, Isao MATSUURA, et al. · Proceedings of the Japan Academy Series B · 1

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Neurofilament Light Chain as a Key Predictor of Cognitive Function and Mortality in Centenarians: A Study of Plasma Neural Biomarkers in Aging

2025 · Yasumichi Arai, Ryo Shikimoto, et al. · Research Square

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Circulating tumor DNA is an independent prognostic factor in patients with early-stage epithelial ovarian cancer

2018 · A. Ogasawara, T. Hihara, et al. · Gynecologic Oncology

Evaluation of circulating tumor DNA in patients with endometrial cancer harboring somatic PIK3CA or KRAS mutations: A potential high-risk factor for recurrence

2018 · D. Shintani, T. Hihara, et al. · Gynecologic Oncology

ChemInform Abstract: Syntheses and Evaluation of Quinoline Derivatives as Novel Retinoic Acid Receptor α Antagonists.

2001 · Kouichi Kikuchi, Katsuya Tagami, et al. · ChemInform

Works count: 28

Citation count: 333

H-index: 12

I10-index: 12