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Isao Yasumatsu

Observed names: I Yasumatsu, Isao YASUMATSU
ORCID: 0009-0000-9865-4835
Observed ORCID: 0009-0000-9865-4835
OpenAlex ID: A5032517716
Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor
2017 · Daisuke Honma, Osamu Kanno, et al. · Cancer Science · 147
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Mechanisms of action and resistance in histone methylation-targeted therapy
2024 · Makoto Yamagishi, Yuta Kuze, et al. · Nature · 129
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Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator
2017 · Yumi Matsui, Isao Yasumatsu, et al. · Bioorganic & Medicinal Chemistry · 31
Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease
2020 · Katsushi Katayama, Ken Ishii, et al. · ACS Medicinal Chemistry Letters · 30
Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines
2020 · Katsushi Katayama, Ken Ishii, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity
2019 · Toru Taniguchi, Hiroaki Inagaki, et al. · ACS Medicinal Chemistry Letters · 27
Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo
2010 · Hiroki Shimizu, Isao Yasumatsu, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Quantitative Structure‐activity Relationship (QSAR) Models for Docking Score Correction
2016 · Yoshifumi Fukunishi, Satoshi Yamasaki, et al. · Molecular Informatics · 21
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Discovery of imidazo[1,2-b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationship
2010 · Hiroki Shimizu, Shinji Tanaka, et al. · Bioorganic & Medicinal Chemistry Letters · 21
A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1
2018 · Yumi Matsui, Isao Yasumatsu, et al. · Acta Crystallographica Section F Structural Biology Communications · 18
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Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation
2023 · Hideaki Kageji, Takayuki Momose, et al. · Bioorganic & Medicinal Chemistry Letters · 10
Flexibility and Cell Permeability of Cyclic Ras-Inhibitor Peptides Revealed by the Coupled Nosé–Hoover Equation
2021 · Kei Moritsugu, Koh Takeuchi, et al. · Journal of Chemical Information and Modeling · 9
Design and Synthesis of Carboxylate Inhibitors for Matrix Metalloproteinases.
2001 · Tetsunori FUJISAWA, Shin-ichi KATAKURA, et al. · Chemical and Pharmaceutical Bulletin · 7
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Stabilities of internal rU-dG and rG-dT pairs in RNA/DNA hybrids.
1997 · N Sugimoto, I Yasumatsu, et al. · PubMed · 5
Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17
2011 · Masaki Kiga, Fumie Tanzawa, et al. · Anti-Cancer Drugs · 3
A New Concept for the Design of Antisense Oligonucleotides Based on Nucleic Acid Thermostability
2001 · Naoki Sugimoto, Isao Yasumatsu · Anti-Cancer Agents in Medicinal Chemistry · 3
Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity
2024 · Hideaki Kageji, Takayuki Momose, et al. · Bioorganic & Medicinal Chemistry · 2
Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581
2024 · Toru Taniguchi, Isao Yasumatsu, et al. · ACS Medicinal Chemistry Letters · 2
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Discovery of Forvisirvat (DS-7830a/SP-624), a Brain-Penetrant Sirtuin 6 Activator Derived from Griseofulvin with Antidepressant-Like Effects
2026 · Yasuyuki Ogawa, Keiji Saito, et al. · ACS Medicinal Chemistry Letters
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Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy
2022 · Makoto Yamagishi, Yuta Kuze, et al. · Blood
Abstract B133: Antitumor effects of novel high-hydrophilic and non-ATP-competitive MEK1/2 inhibitor SMK-17.
2011 · Masaki Kiga, Fumie Tanzawa, et al. · Molecular Cancer Therapeutics
ChemInform Abstract: Design and Synthesis of Carboxylate Inhibitors for Matrix Metalloproteinases.
2002 · Tetsunori Fujisawa, Shin‐ichi Katakura, et al. · ChemInform
Specific Effect of Rare Earth Ions on the Binding between a Ribozyme and a Substrate-The Analysis by Using a Surface Plasmon Resonance
1996 · Tatsuo Ohmichi, Isao Yasumatsu, et al. · 希土類 = Rare earths
Works count: 23
Citation count: 515
H-index: 10
I10-index: 11
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