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Ewald T.J. van den Bremer

Observed names: E T J van den Bremer, Ewald T J van den Bremer, Ewald T. J. van den Bremer, Ewald TJ van den Bremer, Ewald T.J. van den Bremer
Observed institutions: Utrecht University, Genmab (United States), Genmab (Netherlands), Genmab (Denmark), University of York, Wageningen University & Research
ORCID: 0000-0002-3730-7044
Observed ORCID: 0000-0002-3730-7044
OpenAlex ID: A5033110998
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
2013 · Aran F. Labrijn, Joyce I. Meesters, et al. · Proceedings of the National Academy of Sciences · 339
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Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo
2009 · Aran F Labrijn, Antonio Ortiz Buijsse, et al. · Nature Biotechnology · 298
Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose
2011 · Michael J. Gramer, Jackie J. Eckblad, et al. · Biotechnology and Bioengineering · 191
Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen
2016 · Guanbo Wang, Rob N. de Jong, et al. · Molecular Cell · 160
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Controlled Fab-arm exchange for the generation of stable bispecific IgG1
2014 · Aran F Labrijn, Joyce I Meesters, et al. · Nature Protocols · 143
Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3–CH3 Interaction Strength
2011 · Aran F Labrijn, Theo Rispens, et al. · The Journal of Immunology · 136
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Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector
2015 · Andrey Dyachenko, Guanbo Wang, et al. · Analytical Chemistry · 90
Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry
2011 · Rebecca J. Rose, Aran F. Labrijn, et al. · Structure · 87
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Production of stable bispecific IgG1 by controlled Fab-arm exchange
2013 · Michael J Gramer, Ewald TJ van den Bremer, et al. · mAbs · 83
In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap
2013 · Sara Rosati, Ewald TJ van den Bremer, et al. · mAbs · 81
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Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
2015 · Ewald TJ van den Bremer, Frank J Beurskens, et al. · mAbs · 67
Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG
2013 · Rebecca J. Rose, Patrick H.C. van Berkel, et al. · mAbs · 67
Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time‐of‐flight mass spectrometry
2002 · Ewald T.J. van den Bremer, Wim Jiskoot, et al. · Protein Science · 59
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Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry
2017 · Guanbo Wang, Rob N. de Jong, et al. · Analytical Chemistry · 52
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Carbamylation reduces the capacity of IgG for hexamerization and complement activation
2019 · R Lubbers, S C Oostindie, et al. · Clinical & Experimental Immunology · 17
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Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange
2017 · Ewald T. J. van den Bremer, Aran F. Labrijn, et al. · Analytical Chemistry · 14
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Distinct conformational stability and functional activity of four highly homologous endonuclease colicins
2004 · Ewald T.J. van den Bremer, Anthony H. Keeble, et al. · Protein Science · 14
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Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities
2022 · Muriel D. van Kampen, Leonie H.A.M. Kuipers-De Wilt, et al. · Journal of Pharmaceutical Sciences · 13
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Ligand-Induced Changes in the Conformational Dynamics of a Bacterial Cytotoxic Endonuclease
2004 · Ewald T. J. van den Bremer, Anthony H. Keeble, et al. · Biochemistry · 8
Metal induced selectivity in phosphate ion binding in E9 DNase
2005 · Ewald T. J. van den Bremer, Anthony H. Keeble, et al. · Chemical Communications · 2
Impact of IgG oligomerization state on the potency of complement-dependent cytotoxicity
2016 · Frank J. Beurskens, Rob N. de Jong, et al. · Immunobiology
Structure-function relationships of E-type endonuclease colicins
2004 · Ewald T.J. van den Bremer · Utrecht University Repository (Utrecht University)
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Works count: 22
Citation count: 1,922
H-index: 15
I10-index: 18
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