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Josh Lehrer‐Graiwer
Observed names:
J. Lehrer-Graiwer,
J. Lehrer‐Graiwer,
Josh Lehrer-Graiwer
Institution:
Global Blood Therapeutics (United States)
Observed institution:
Global Blood Therapeutics (United States)
OpenAlex ID:
A5033198503
Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease
2019
·
Athiwat Hutchaleelaha
, Mira Patel
, et al.
·
British Journal of Clinical Pharmacology
·
102
PDF
GBT1118, a potent allosteric modifier of hemoglobin O2affinity, increases tolerance to severe hypoxia in mice
2017
·
Kobina Dufu
, Ozlem Yalcin
, et al.
·
American Journal of Physiology-Heart and Circulatory Physiology
·
33
GBT440, a Potent Anti-Sickling Hemoglobin Modifier Reduces Hemolysis, Improves Anemia and Nearly Eliminates Sickle Cells in Peripheral Blood of Patients with Sickle Cell Disease
2015
·
Josh Lehrer-Graiwer
, Jo Howard
, et al.
·
Blood
·
29
Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease
2018
·
Paul Telfer
, Irene Agodoa
, et al.
·
Hematology Reports
·
21
GBT440 Inhibits Sickling of Sickle Cell Trait Blood under In Vitro Conditions Mimicking Strenuous Exercise
2016
·
Kobina Dufu
, Josh Lehrer-Graiwer
, et al.
·
Hematology Reports
·
19
PDF
Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis
2016
·
Xin Geng
, Kobina Dufu
, et al.
·
Physiological Reports
·
17
PDF
Long-Term Dosing in Sickle Cell Disease Subjects with GBT440, a Novel HbS Polymerization Inhibitor
2016
·
Josh Lehrer-Graiwer
, Jo Howard
, et al.
·
Blood
·
15
Effects of an allosteric hemoglobin affinity modulator on arterial blood gases and cardiopulmonary responses during normoxic and hypoxic low-intensity exercise
2020
·
Glenn M. Stewart
, Steven Chase
, et al.
·
Journal of Applied Physiology
·
13
Impact of Pharmacologically Left Shifting the Oxygen–Hemoglobin Dissociation Curve on Arterial Blood Gases and Pulmonary Gas Exchange During Maximal Exercise in Hypoxia
2021
·
Glenn M. Stewart
, Troy J. Cross
, et al.
·
High Altitude Medicine & Biology
·
11
Pharmacokinetics of Voxelotor in Patients With Renal and Hepatic Impairment
2020
·
Richard A. Preston
, Thomas Marbury
, et al.
·
The Journal of Clinical Pharmacology
·
11
PDF
GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury
2018
·
Nathan D. Putz
, Ciara M. Shaver
, et al.
·
Journal of Applied Physiology
·
10
The 10-Item Sickle Cell Disease Severity Measure (SCDSM-10): A Novel Measure of Daily SCD Symptom Severity Developed to Assess Benefit of GBT440, an Experimental HbS Polymerization Inhibitor
2016
·
Laurie Burke
, Jeremy Charles Hobart
, et al.
·
Blood
·
2
Voxelotor (GBT440), a Hemoglobin-Oxygen Affinity Modulator, Increases Oxygen Saturation in IPF Patients Who Desaturate with Exercise
2020
·
L. Lancaster
, H.R. Collard
, et al.
·
1
Abstract 10826: GBT1118, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity Increases Tolerance to Hypoxia in Mice
2015
·
Pedro Cabrales
, Kobina Dufu
, et al.
·
Circulation
·
1
S147 Results From the Randomized Placebo‐controlled Phase 3 Hope Trial of Voxelotor in Adults and Adolescents With Sickle Cell Disease
2019
·
E. Vichinsky
, C.C. Hoppe
, et al.
·
HemaSphere
Small Molecule Inhibitors of De Novo Cell-free Capsid Assembly Effective against Flaviviridae and Togaviridae
2010
·
Vishwanath R. Lingappa
, Juliane Gentzsch
, et al.
·
Antiviral Research
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Works count:
16
Citation count:
285
H-index:
10
I10-index:
11
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