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Manuela Benvenuti
Observed names:
Benvenuti Manuela,
Benvenuti, Manuela,
M Benvenuti,
M. Benvenuti
Institution:
University of Siena
Observed institutions:
University of Siena,
Brookhaven National Laboratory,
University of Massachusetts Amherst,
Ospedale Santa Maria alle Scotte,
Azienda Ospedaliero-Universitaria Careggi,
University of Florence
show all 6
ORCID:
0000-0003-0709-2537
Observed ORCID:
0000-0003-0709-2537
OpenAlex ID:
A5033267424
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
2019
·
Bin Liu
, Robert E. Lee Trout
, et al.
·
Journal of Medicinal Chemistry
·
323
Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-Lactamases
2013
·
Sushmita D. Lahiri
, Stefano Mangani
, et al.
·
Antimicrobial Agents and Chemotherapy
·
232
PDF
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa
2019
·
Jodie C. Hamrick
, Jean-Denis Docquier
, et al.
·
Antimicrobial Agents and Chemotherapy
·
228
Crystal Structure of the OXA-48 β-Lactamase Reveals Mechanistic Diversity among Class D Carbapenemases
2009
·
Jean-Denis Docquier
, Vito Calderone
, et al.
·
Chemistry & Biology
·
178
Crystallization of soluble proteins in vapor diffusion for x-ray crystallography
2007
·
Manuela Benvenuti
, Stefano Mangani
·
Nature Protocols
·
166
Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48
2014
·
Sushmita D. Lahiri
, Stefano Mangani
, et al.
·
ACS Chemical Biology
·
108
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design
2011
·
Filomena De Luca
, Manuela Benvenuti
, et al.
·
Proceedings of the National Academy of Sciences
·
69
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model
2018
·
Simon Leiris
, Alicia Coelho
, et al.
·
ACS Infectious Diseases
·
61
PDF
The Evolutionarily Conserved Trimeric Structure of CutA1 Proteins Suggests a Role in Signal Transduction
2003
·
Fabio Arnesano
, Lucia Banci
, et al.
·
Journal of Biological Chemistry
·
54
PDF
ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae
2020
·
David T. Davies
, Simon Leiris
, et al.
·
ACS Infectious Diseases
·
52
High-Resolution Crystal Structure of the Subclass B3 Metallo-β-Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides
2010
·
Jean-Denis Docquier
, Manuela Benvenuti
, et al.
·
Antimicrobial Agents and Chemotherapy
·
51
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors
2020
·
Laurent Gavara
, Laurent Sevaille
, et al.
·
European Journal of Medicinal Chemistry
·
48
Discovery of ANT3310 , a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii
2020
·
David T. Davies
, Simon Leiris
, et al.
·
Journal of Medicinal Chemistry
·
42
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders
2018
·
Cecilia Pozzi
, Flavio Di Pisa
, et al.
·
JBIC Journal of Biological Inorganic Chemistry
·
40
Polymerization and copolymerization of β‐butyrolactone and benzyl‐β‐malolactonate by aluminoxane catalysts
1991
·
Manuela Benvenuti
, Robert W. Lenz
·
Journal of Polymer Science Part A Polymer Chemistry
·
38
Crystal Structure of the Narrow-Spectrum OXA-46 Class D β-Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates
2010
·
Jean-Denis Docquier
, Manuela Benvenuti
, et al.
·
Antimicrobial Agents and Chemotherapy
·
37
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity
2021
·
Alice Legru
, Federica Verdirosa
, et al.
·
European Journal of Medicinal Chemistry
·
32
The First Structure of a Bacterial Class B Acid Phosphatase Reveals Further Structural Heterogeneity Among Phosphatases of the Haloacid Dehalogenase Fold
2003
·
Vito Calderone
, Costantino Forleo
, et al.
·
Journal of Molecular Biology
·
32
Synthesis and physicochemical characterization of a new material (PUPA) based on polyurethane and poly(amido-amine) components capable of strongly adsorbing quantities of heparin
1989
·
R. Barbucci
, M. Benvenuti
, et al.
·
Biomaterials
·
32
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates
2022
·
Alice Legru
, Federica Verdirosa
, et al.
·
Journal of Medicinal Chemistry
·
27
Heparinizable materials, 5. Preparation and FTIR characterization of polyurethane surfaces grafted with heparin‐complexing poly(amido‐amine) chains
1985
·
Rolando Barbucci
, Manuela Benvenuti
, et al.
·
Die Makromolekulare Chemie
·
25
A Structure-based Proposal for the Catalytic Mechanism of the Bacterial Acid Phosphatase AphA belonging to the DDDD Superfamily of Phosphohydrolases
2005
·
Vito Calderone
, Costantino Forleo
, et al.
·
Journal of Molecular Biology
·
22
PDF
Chemical and biological evaluation of heparinized poly(amido-amine) grafted polyurethane
1987
·
G. Azzuoli
, R. Barbucci
, et al.
·
Biomaterials
·
22
Surface characterization of heparin‐complexing poly(amido amine) chains grafted on polyurethane and glass surfaces
1987
·
Rolando Barbucci
, Adam Baszkin
, et al.
·
Journal of Biomedical Materials Research
·
21
Atomic‐Resolution Structure of a Class C β‐Lactamase and Its Complex with Avibactam
2018
·
Cecilia Pozzi
, Flavio Di Pisa
, et al.
·
ChemMedChem
·
18
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Works count:
60
Citation count:
2,150
H-index:
22
I10-index:
35
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