Author

Lisa A. Hasvold

Observed names: L. A. HASVOLD, L. HASVOLD, L. Hasvold, Lisa Hasvold

Observed institutions: Iowa State University, AbbVie (United States), Abbott (United States), Technical University of Munich, University of Gothenburg, Umeå University

OpenAlex ID: A5033294241

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

2020 · Emily J. Faivre, Keith F. McDaniel, et al. · Nature · 412

Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity

2014 · Zhi-Fu Tao, Lisa Hasvold, et al. · ACS Medicinal Chemistry Letters · 313

Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides

1996 · Richard C. Larock, Timothy R. Hightower, et al. · The Journal of Organic Chemistry · 278

Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity

2015 · Milan Bruncko, Le Wang, et al. · Journal of Medicinal Chemistry · 167

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

2017 · Keith F. McDaniel, Le Wang, et al. · Journal of Medicinal Chemistry · 148

Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

2020 · George S. Sheppard, Le Wang, et al. · Journal of Medicinal Chemistry · 140

Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

2011 · Andreas Höglund, Lisa M. Nilsson, et al. · Clinical Cancer Research · 136

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

2017 · Mai H. Bui, Xiaoyu Lin, et al. · Cancer Research · 124

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

2009 · Zhi-Fu Tao, Lisa A. Hasvold, et al. · Journal of Medicinal Chemistry · 86

Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

1996 · Qun Li, Daniel T. W. Chu, et al. · Journal of Medicinal Chemistry · 76

Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

2003 · Lisa A. Hasvold, Weibo Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 73

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

2017 · Le Wang, John K. Pratt, et al. · Journal of Medicinal Chemistry · 67

Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[ b , e ][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

2007 · Le Wang, Gerard M. Sullivan, et al. · Journal of Medicinal Chemistry · 44

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL

2014 · Michael F. T. Koehler, Philippe Bergeron, et al. · ACS Medicinal Chemistry Letters · 39

Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents

1998 · Qun Li, Weibo Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 37

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

2006 · Gaoquan Li, Lisa A. Hasvold, et al. · Bioorganic & Medicinal Chemistry Letters · 34

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

2003 · Stephen L. Gwaltney, Stephen J. O'Connor, et al. · Bioorganic & Medicinal Chemistry Letters · 34

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors

2004 · Qun Li, Akiyo Claiborne, et al. · Bioorganic & Medicinal Chemistry Letters · 26

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability

2003 · Yunsong Tong, Nan-Horng Lin, et al. · Bioorganic & Medicinal Chemistry Letters · 26

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency

2003 · Stephen L. Gwaltney, Stephen J. O'Connor, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Methylpyrrole inhibitors of BET bromodomains

2017 · Lisa A. Hasvold, George S. Sheppard, et al. · Bioorganic & Medicinal Chemistry Letters · 21

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

2008 · Lisa A. Hasvold, Le Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 15

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

2004 · Gary T. Wang, Xilu Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 15

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

2018 · Steven D. Fidanze, Dachun Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 13

Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

2003 · Weibo Wang, Qun Li, et al. · Bioorganic & Medicinal Chemistry Letters · 12

Works count: 65

Citation count: 2,388

H-index: 21

I10-index: 26