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Roger Flores‐Costa

Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure
2021 · Ingrid W. Zhang, Anna Curto, et al. · Journal of Hepatology · 121
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Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen‐Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis
2018 · José Alcaraz‐Quiles, Mireia Casulleras, et al. · Hepatology · 100
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Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome
2018 · Aritz Lopategi, Roger Flores-Costa, et al. · Journal of Leukocyte Biology · 91
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Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis
2020 · Mireia Casulleras, Roger Flores-Costa, et al. · Science Translational Medicine · 87
The soluble guanylate cyclase stimulator IW‐1973 prevents inflammation and fibrosis in experimental non‐alcoholic steatohepatitis
2017 · Roger Flores‐Costa, José Alcaraz‐Quiles, et al. · British Journal of Pharmacology · 71
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The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia‐induced endoplasmic reticulum stress
2017 · Bibiana Rius, Marta Duran‐Güell, et al. · The FASEB Journal · 69
Leukocytes from obese individuals exhibit an impaired SPM signature
2019 · Cristina López-Vicario, Esther Titos, et al. · The FASEB Journal · 65
Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit
2020 · Roger Flores-Costa, Marta Duran-Güell, et al. · Proceedings of the National Academy of Sciences · 64
Albumin protects the liver from tumor necrosis factor α‐induced immunopathology
2021 · Marta Duran‐Güell, Roger Flores‐Costa, et al. · The FASEB Journal · 60
Small fragments of hyaluronan are increased in individuals with obesity and contribute to low-grade inflammation through TLR-mediated activation of innate immune cells
2022 · Mònica Romo, Cristina López-Vicario, et al. · International Journal of Obesity · 52
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Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease
2022 · Cristina López‐Vicario, David Sebastián, et al. · Hepatology · 28
Essential role for albumin in preserving liver cells from TNFα‐induced mitochondrial injury
2023 · Marta Duran‐Güell, Glòria Garrabou, et al. · The FASEB Journal · 25
Proresolving lipid mediators and liver disease
2021 · Joan Clària, Roger Flores-Costa, et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 19
Palmitoylcarnitine impairs immunity in decompensated cirrhosis
2024 · Ingrid Wei Zhang, María Belén Sánchez-Rodríguez, et al. · JHEP Reports · 16
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Albumin Lipidomics Reveals Meaningful Compositional Changes in Advanced Cirrhosis and Its Potential to Promote Inflammation Resolution
2022 · Mireia Casulleras, Roger Flores‐Costa, et al. · Hepatology Communications · 16
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
2017 · on behalf of the Ironwood team, G. Todd Milne, et al. · BMC Pharmacology and Toxicology · 16
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The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis
2017 · R. Flores-Costa, J. Alcaraz-Quiles, et al. · Journal of Hepatology · 5
An optimized peritonitis-induced ACLF model that reproduces the full spectrum of extrahepatic organ failures in mice
2025 · Roger Flores-Costa, Marta Duran-Güell, et al. · Hepatology Communications · 3
FRI-111-Albumin modulates endosomal TLR9 signaling in human peripheral leukocytes: A mechanism for its anti-inflammatory role in ACLF
2019 · Mireia Casulleras, José Alcaraz-Quiles, et al. · Journal of Hepatology · 3
FRI-296-Interaction between the soluble guanylate cyclase and the NLRP3 inflammasome in Kupffer cells: Implications for the anti-inflammatory actions of sGC stimulation in liver
2019 · Roger Flores-Costa, Marta Duran-Güell, et al. · Journal of Hepatology · 1
Increased liver content of omega-3-derived lipid mediators associates with enhanced mitochondrial oxidative phosphorylation, fatty acid oxidation and metabolic efficiency
2022 · Cristina López-Vicario, David Sebastián, et al. · Journal of Hepatology
Long-chain acylcarnitines promote leukocyte mitochondrial dysfunction: role in patients with acutely decompensated cirrhosis
2022 · Ingrid Wei Zhang, Cristina López-Vicario, et al. · Journal of Hepatology
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Combination of CCL4-induced decompensated cirrhosis with acute polymicrobial peritonitis as an optimized experimental model mimicking extrahepatic organ failures defined in ACLF
2022 · Roger Flores-Costa, Albert Salvatella, et al. · Journal of Hepatology
Patients with acutely decompensated cirrhosis present a distorted blood lipid landscape that affects the ability of albumin to promote inlammation resolution
2022 · Mireia Casulleras, Roger Flores-Costa, et al. · Journal of Hepatology
PS-145-Albumin protects the liver from tumour necrosis factor alpha-induced cell death
2019 · Marta Duran-Güell, Mireia Casulleras, et al. · Journal of Hepatology
Works count: 27
Citation count: 912
H-index: 16
I10-index: 16
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