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Leon P. Pybus

Observed name: Leon Pybus
ORCID: 0000-0001-5614-8758
Observed ORCID: 0000-0001-5614-8758
OpenAlex ID: A5033911467
Model‐ d irected engineering of “difficult‐to‐ e xpress” monoclonal antibody production by Chinese hamster ovary cells
2013 · Leon P. Pybus, Greg Dean, et al. · Biotechnology and Bioengineering · 109
Cell line‐specific control of recombinant monoclonal antibody production by CHO cells
2010 · Peter M. O'Callaghan, Jane McLeod, et al. · Biotechnology and Bioengineering · 105
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes
2010 · Matt J. Barter, Leon Pybus, et al. · Matrix Biology · 94
Scale‐Down Model Development in ambr systems: An Industrial Perspective
2018 · Viktor Sandner, Leon P. Pybus, et al. · Biotechnology Journal · 69
Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells
2011 · Sarah L. Davies, Peter M. O'Callaghan, et al. · Biotechnology Progress · 40
Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain
2013 · Leon P. Pybus, David C. James, et al. · Biotechnology Progress · 24
An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer
2011 · Jane McLeod, Peter M. O'Callaghan, et al. · Biotechnology and Bioengineering · 23
Microbioreactor for lower cost and faster optimisation of protein production
2020 · Mayur Parekh, AbdulAziz Ali, et al. · The Analyst · 19
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Coupling picodroplet microfluidics with plate imaging for the rapid creation of biomanufacturing suitable cell lines with high probability and improved multi‐step assurance of monoclonality
2021 · Leon P. Pybus, Devika Kalsi, et al. · Biotechnology Journal · 17
Deciphering molecular drivers of lactate metabolic shift in mammalian cell cultures
2024 · Mauro Torres, Ellie Hawke, et al. · Metabolic Engineering · 14
Dissecting cell death pathways in fed‐batch bioreactors
2023 · David A. Mentlak, John Raven, et al. · Biotechnology Journal · 12
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A modular and multi‐functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing
2024 · Leon P. Pybus, Charles Heise, et al. · Biotechnology Progress · 9
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Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells
2025 · Kate E. Meeson, Joanne Watson, et al. · Biotechnology and Bioengineering · 6
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From Discovery to Delivery: A Rapid and Targeted Proteomics Workflow for Monitoring Chinese Hamster Ovary Biomanufacturing
2025 · Charles Eldrid, Ellie Hawke, et al. · Molecular & Cellular Proteomics · 3
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Use of tRNA gene barriers improves stability of transgene expression in CHO cells
2024 · Rebecca E. Sizer, Richard M. Ingram, et al. · Biotechnology Journal · 2
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Reconstruction of arginine deiminase pathway sustains a higher-energy state in mammalian cells
2026 · Mauro Torres, Matthew Reaney, et al. · Metabolic Engineering · 1
Engineering TPT1-mediated apoptosis resistance for improved mammalian cell biomanufacturing
2026 · Javier Bravo-Venegas, Zeynep Betts, et al. · Metabolic Engineering
Fatty Acid β-oxidation and Ferroptosis Define a Survival-Productivity Trade Off in CHO fed-Batch Bioreactors
2026 · Charles Eldrid, John Raven, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Author response for "A modular and multi‐functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing"
2024 · Leon P. Pybus, Charles Heise, et al. · Publons reviews and discussion
Author response for "A modular and multi‐functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing"
2023 · Leon P. Pybus, Charles Heise, et al. · Publons reviews and discussion
Microfluidic Microbioreactor to Reduce the Cost and Speed Up Optimisation of Protein Production
2020 · Mayur Parekh, abdulaziz ali, et al. · ChemRxiv
Platform based screening strategies that deliver reliable and high quality continous biomanufacturing processes
2018 · Leon P. Pybus, Tatsuya Matsuura, et al.
Engineering the expression of "difficult-to-express" recombinant monoclonal antibodies in Chinese hamster ovary cells
2014 · Leon P. Pybus · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Works count: 23
Citation count: 547
H-index: 11
I10-index: 11
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