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Garrick Paul Smith

Observed names: G. P. SMITH, G.P. Smith, Garrick P. Smith, Garrick Smith
Institution: Lundbeck (Denmark)
ORCID: 0000-0001-8920-3514
Observed ORCID: 0000-0001-8920-3514
OpenAlex ID: A5033981228
Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder
2011 · Benny Bang-Andersen, Thomas Ruhland, et al. · Journal of Medicinal Chemistry · 621
Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells
2017 · Kenneth Thirstrup, Justus C. Dächsel, et al. · Scientific Reports · 99
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Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain
2016 · Hagit Sason, Jean Marie Billard, et al. · Cerebral Cortex · 74
PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats
2018 · Michael Aagaard Andersen, Karen Malene Wegener, et al. · Toxicology · 66
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Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats
2011 · John P. Redrobe, Lisbeth Elster, et al. · Psychopharmacology · 60
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139
2011 · Feng Shi, Jing Kang Shen, et al. · ACS Medicinal Chemistry Letters · 54
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)
2017 · Douglas S. Williamson, Garrick P. Smith, et al. · Journal of Medicinal Chemistry · 49
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The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors
2006 · Garrick Smith, Gitte Mikkelsen, et al. · Bioorganic & Medicinal Chemistry Letters · 41
Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate
2021 · Douglas S. Williamson, Garrick P. Smith, et al. · Journal of Medicinal Chemistry · 38
High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139
2015 · Jia Wang, Lin-yun Zhu, et al. · Acta Pharmacologica Sinica · 35
Design and Synthesis of Thrombin Inhibitors: Analogues of MD-805 with Reduced Stereogenicity and Improved Potency
1999 · Derek Brundish, Alice Bull, et al. · Journal of Medicinal Chemistry · 30
The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors
2004 · Garrick Smith, Thomas Ruhland, et al. · Bioorganic & Medicinal Chemistry Letters · 29
Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation
2018 · Michael Aagaard Andersen, Kenneth Vielsted Christensen, et al. · Neurobiology of Disease · 27
Development of LRRK2 Inhibitors for the Treatment of Parkinson's Disease
2017 · K.V. Christensen, G.P. Smith, et al. · Progress in medicinal chemistry · 24
Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP+ and Rotenone Toxicity
2016 · Kirsten Bayer Andersen, Jens Leander Johansen, et al. · Frontiers in Cellular Neuroscience · 21
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Synthesis and Application of a New Fluorous‐Tagged Ammonia Equivalent
2010 · Simon D. Nielsen, Garrick Smith, et al. · Chemistry - A European Journal · 20
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors
2017 · Garrick P. Smith, Lassina Badolo, et al. · Bioorganic & Medicinal Chemistry Letters · 17
LRRK2 exonic variants associated with Parkinson’s disease augment phosphorylation levels for LRRK2-Ser1292 and Rab10-Thr73
2018 · Kenneth V. Christensen, Morten Hentzer, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 14
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Amination of Aryl Iodides Using a Fluorous‐Tagged Ammonia Equivalent
2010 · Simon Dalsgaard Nielsen, Garrick Smith, et al. · European Journal of Organic Chemistry · 14
Synthesis of N-alkylated amino acids using fluorous-tagged hydroxylamines
2011 · Simon D. Nielsen, Garrick P. Smith, et al. · Tetrahedron · 10
Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications
2019 · Michael Aagaard Andersen, Florence Sotty, et al. · eNeuro · 8
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Synthesis of analogues of squalene as potential anti-fungal agents
1993 · Albert Duriati, Michel Jung, et al. · Journal of the Chemical Society Perkin Transactions 1 · 8
Synthesis of potential inhibitors of squalene epoxidase
1991 · John Mann, Garrick P. Smith · Journal of the Chemical Society Perkin Transactions 1 · 7
Development of 18F/11C-Labeled Pyrrolo-Pyridine/Pyrimidine LRRK2 Selective PET Radioligands
2025 · Sangram Nag, Vladimir Stepanov, et al. · Pharmaceuticals · 2
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The Synthesis and SAR of 2‐Arylsulfanylphenyl‐1‐oxyalkylamino Acids as GlyT‐1 Inhibitors.
2006 · Garrick Smith, Gitte Mikkelsen, et al. · ChemInform · 2
Works count: 31
Citation count: 1,370
H-index: 17
I10-index: 20
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