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Author

Sita Kugel

Observed name: Kugel, Sita
Observed institutions: Harvard University, Wayne State University, University of Washington, Massachusetts General Hospital, Fred Hutch Cancer Center, Brotman Baty Institute
ORCID: 0000-0001-7202-187X
Observed ORCID: 0000-0001-7202-187X
OpenAlex ID: A5034075190
Chromatin and beyond: the multitasking roles for SIRT6
2014 · Sita Kugel, Raul Mostoslavsky · Trends in Biochemical Sciences · 367
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
2016 · Sita Kugel, Carlos Sebastián, et al. · Cell · 295
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The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine
2015 · Jean-Pierre Etchegaray, Lukas Chavez, et al. · Nature Cell Biology · 153
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Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer
2015 · Sita Kugel, Jessica L. Feldman, et al. · Cell Reports · 81
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
2021 · Stephanie Dobersch, Karla Rubio, et al. · Nature Communications · 53
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RNA polymerase II at histone genes predicts outcome in human cancer
2025 · Steven Henikoff, Ye Zheng, et al. · Science · 52
Multiomic characterization of RNA microenvironments by oligonucleotide-mediated proximity-interactome mapping
2024 · Ashley F. Tsue, Evan E. Kania, et al. · Nature Methods · 45
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Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT&Tag
2023 · Steven Henikoff, Jorja G. Henikoff, et al. · Nature Communications · 37
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SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma
2024 · Iris S. Luk, Caroline M. Bridgwater, et al. · Science Translational Medicine · 18
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Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases
2023 · Nithya Kartha, Jessica E. Gianopulos, et al. · Science Translational Medicine · 15
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Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6
2015 · Mike R. Wilson, Sita Kugel, et al. · Biochemical Journal · 14
HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma
2024 · Naomi Yamamoto, Stephanie Dobersch, et al. · Clinical Cancer Research · 12
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases
2024 · Christina M. Ferrer, Hyo Min Cho, et al. · Nature Cell Biology · 11
Oligonucleotide-directed proximity-interactome mapping (O-MAP): A unified method for discovering RNA-interacting proteins, transcripts and genomic loci in situ
2023 · Ashley F. Tsue, Evan E. Kania, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 9
Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer
2020 · Sita Kugel, Sunil R. Hingorani · Cancer Cell · 9
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SIRT1 Activators: The Evidence STACks up
2013 · Sita Kugel, Raul Mostoslavsky · Aging · 8
HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
2025 · Stephanie Dobersch, Naomi Yamamoto, et al. · Nature Communications · 7
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Small-molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells
2025 · Michelle A. Lum, Kayla A. Jonas, et al. · Journal of Clinical Investigation · 7
Phase II Study of Pegvorhyaluronidase Alfa (PEGPH20) and Pembrolizumab for Patients with Hyaluronan-High, Pretreated Metastatic Pancreatic Ductal Adenocarcinoma: PCRT16-001
2026 · Elena Gabriela Chiorean, Sheela R. Damle, et al. · Cancers · 6
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Phase 2 study of azacitidine plus pembrolizumab as second-line treatment in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma
2026 · Rachael A Safyan, Ruth A White, et al. · The Oncologist · 3
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Therapeutic targeting of the eIF4E cap-binding domain reveals control of lineage fate in prostate cancer
2026 · Rashmi Mishra, Sihyeon Song, et al. · Journal of Clinical Investigation · 2
MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer
2026 · Erin L. Ramsey, Stephanie Dobersch, et al. · Proceedings of the National Academy of Sciences · 1
MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic ductal adenocarcinoma
2025 · Erin L. Ramsey, Stephanie Dobersch, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Long-Term Survival Following Chemoradiation in Locoregional Recurrent Germline ATM Mutated Pancreatic Ductal Adenocarcinoma
2025 · Rachael A. Safyan, Keven Zhang, et al. · Advances in Radiation Oncology · 1
Abstract PR12: Targeting CDK7/9 in basal pancreatic cancer
2024 · Sita Kugel, Nithya Kartha, et al. · Cancer Research · 1
Works count: 71
Citation count: 1,207
H-index: 12
I10-index: 13
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