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Jacob I. Ayers

Observed names: Ayers, Jacob I., J. I. Ayers, Jacob Ayers, Jacob I Ayers
ORCID: 0000-0003-4544-2366
Observed ORCID: 0000-0003-4544-2366
OpenAlex ID: A5034424187
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
2014 · Amanda N. Sacino, Mieu Brooks, et al. · Proceedings of the National Academy of Sciences · 337
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
2021 · Evan Lester, Felicia K. Ooi, et al. · Neuron · 217
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Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways
2015 · Jacob I. Ayers, Susan E. Fromholt, et al. · Acta Neuropathologica · 161
Experimental transmissibility of mutant SOD1 motor neuron disease
2014 · Jacob I. Ayers, Susan Fromholt, et al. · Acta Neuropathologica · 128
The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease
2011 · Jacob I. Ayers, Charles R. Schutt, et al. · PLoS Pathogens · 112
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Prion-like Spreading in Tauopathies
2017 · Jacob I. Ayers, Benoit I. Giasson, et al. · Biological Psychiatry · 105
Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils
2016 · Jacob I. Ayers, Mieu M. Brooks, et al. · Journal of Virology · 97
Coinfecting Prion Strains Compete for a Limiting Cellular Resource
2010 · Ronald A. Shikiya, Jacob I. Ayers, et al. · Journal of Virology · 85
Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice
2014 · Jacob I Ayers, Susan Fromholt, et al. · Molecular Therapy · 83
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy
2022 · Jacob I. Ayers, Joanne Lee, et al. · Proceedings of the National Academy of Sciences · 79
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Prion Interference Is Due to a Reduction in Strain-Specific PrP Sc Levels
2006 · Jason C. Bartz, Michelle L. Kramer, et al. · Journal of Virology · 69
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS
2016 · Jacob I. Ayers, Jeffrey Diamond, et al. · Acta Neuropathologica · 57
Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases
2014 · Jacob I Ayers, Guilian Xu, et al. · Acta Neuropathologica Communications · 51
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ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons
2018 · Zachary Osking, Jacob I. Ayers, et al. · iScience · 47
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Expanding spectrum of prion diseases
2020 · Jacob I. Ayers, Nick A. Paras, et al. · Emerging Topics in Life Sciences · 45
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Prion-like mechanisms in amyotrophic lateral sclerosis
2018 · Jacob I. Ayers, Neil R. Cashman · Handbook of clinical neurology · 44
Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism
2008 · Jacob I. Ayers, Anthony E. Kincaid, et al. · Journal of Virology · 41
Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts
2018 · Jacob I. Ayers, Cara J. Riffe, et al. · Journal of Virology · 40
Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding
2017 · Sanaz Rasouli, Alireza Abdolvahabi, et al. · Journal of Biological Chemistry · 33
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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection
2020 · Anthony Crown, Luke McAlary, et al. · PLoS ONE · 29
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Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology
2015 · Amanda N. Sacino, Jacob I. Ayers, et al. · Acta Neuropathologica · 25
Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease
2013 · Jacob Ayers, Herman Lelie, et al. · Journal of Neurochemistry · 24
Phenotypic diversity in ALS and the role of poly-conformational protein misfolding
2020 · Jacob I. Ayers, David R. Borchelt · Acta Neuropathologica · 21
Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models
2016 · Jacob I. Ayers, Benjamin McMahon, et al. · Journal of Neurochemistry · 20
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions
2023 · Carlo Condello, Jacob I. Ayers, et al. · Proceedings of the National Academy of Sciences · 18
Works count: 48
Citation count: 2,107
H-index: 22
I10-index: 32
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