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Heather C. Losey
Observed names:
H. Losey,
H.C. Losey,
Heather C Losey,
Heather Losey
Institution:
Alkermes (United States)
Observed institutions:
Argonne National Laboratory,
Harvard University,
National Institute of Technology and Evaluation,
Princeton University,
Yale University,
Alkermes (United States),
Michigan State University
show all 7
ORCID:
0000-0001-6363-1166
Observed ORCID:
0000-0001-6363-1166
OpenAlex ID:
A5034492598
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines
2001
·
Christopher T Walsh
, Huawei Chen
, et al.
·
Current Opinion in Chemical Biology
·
310
Structure of the UDP-Glucosyltransferase GtfB That Modifies the Heptapeptide Aglycone in the Biosynthesis of Vancomycin Group Antibiotics
2001
·
Anne M. Mulichak
, Heather C. Losey
, et al.
·
Structure
·
200
PDF
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA
2006
·
Heather C Losey
, Alexander J Ruthenburg
, et al.
·
Nature Structural & Molecular Biology
·
189
Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization
1999
·
Cathryn A Shaw-Reid
, Neil L Kelleher
, et al.
·
Chemistry & Biology
·
163
PDF
Tandem Action of Glycosyltransferases in the Maturation of Vancomycin and Teicoplanin Aglycones: Novel Glycopeptides,
2001
·
Heather C. Losey
, Mark W. Peczuh
, et al.
·
Biochemistry
·
159
Structure of the TDP- epi -vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway
2003
·
Anne M. Mulichak
, Heather C. Losey
, et al.
·
Proceedings of the National Academy of Sciences
·
152
Incorporation of Glucose Analogs by GtfE and GtfD from the Vancomycin Biosynthetic Pathway to Generate Variant Glycopeptides
2002
·
Heather C. Losey
, Jiqing Jiang
, et al.
·
Chemistry & Biology
·
152
PDF
ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy
2020
·
Jared E Lopes
, Jan L Fisher
, et al.
·
Journal for ImmunoTherapy of Cancer
·
145
PDF
Crystal Structure of Vancosaminyltransferase GtfD from the Vancomycin Biosynthetic Pathway: Interactions with Acceptor and Nucleotide Ligands,
2004
·
Anne M. Mulichak
, Wei Lu
, et al.
·
Biochemistry
·
131
The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates
2000
·
David E. Ehmann
, Cathryn A. Shaw-Reid
, et al.
·
Proceedings of the National Academy of Sciences
·
116
Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of TDP- l -epivancosamine in chloroeremomycin biosynthesis
2000
·
Huawei Chen
, Michael G. Thomas
, et al.
·
Proceedings of the National Academy of Sciences
·
109
Substrate recognition by class I lysyl-tRNA synthetases: A molecular basis for gene displacement
1999
·
Michael Ibba
, Heather C. Losey
, et al.
·
Proceedings of the National Academy of Sciences
·
99
Antibiotic Glycosyltransferases: Antibiotic Maturation and Prospects for Reprogramming
2003
·
Christopher Walsh
, Caren L. Freel Meyers
, et al.
·
Journal of Medicinal Chemistry
·
74
The Structural Basis for Induction of VanB Resistance
2002
·
Steven D. Dong
, Markus Oberthür
, et al.
·
Journal of the American Chemical Society
·
60
Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization
1999
·
Cathryn A Shaw-Reid
, Neil L Kelleher
, et al.
·
Chemistry & Biology
·
29
PDF
Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys
2021
·
Jared E. Lopes
, Lei Sun
, et al.
·
Journal of Pharmacology and Experimental Therapeutics
·
22
PDF
Antibiotic glycosyltransferases
2003
·
C.T. Walsh
, H.C. Losey
, et al.
·
Biochemical Society Transactions
·
22
Nemvaleukin alfa, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer
2022
·
Yuanwang Pan
, Yuan Hao
, et al.
·
Journal for ImmunoTherapy of Cancer
·
15
PDF
Selection of the recommended phase 2 dose (RP2D) for subcutaneous nemvaleukin alfa: ARTISTRY-2.
2021
·
Omid Hamid
, Stephen V. Liu
, et al.
·
Journal of Clinical Oncology
·
11
Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) fromAmycolatopsis orientalis, the fourth enzyme in the dTDP- L -epivancosamine biosynthetic pathway
2002
·
Alexandra B. Merkel
, Genevieve K. Temple
, et al.
·
Acta Crystallographica Section D Biological Crystallography
·
7
Autologous human preclinical modeling of melanoma interpatient clinical responses to immunotherapeutics
2024
·
Yee Peng Phoon
, Jared E Lopes
, et al.
·
Journal for ImmunoTherapy of Cancer
·
5
PDF
1027MO ALKS 4230 monotherapy and in combination with pembrolizumab (pembro) in patients (pts) with refractory solid tumours (ARTISTRY-1)
2020
·
U.N. Vaishampayan
, J. Muzaffar
, et al.
·
Annals of Oncology
·
5
Selective Agonism of Intermediate-Affinity IL-2 Receptor Promotes Systemic Antitumor Responses in Combination with Radiotherapy in Metastatic Lung Cancer
2022
·
K. He
, N.P. Osorio
, et al.
·
International Journal of Radiation Oncology*Biology*Physics
·
4
347 Clinical outcomes of ovarian cancer patients treated with ALKS 4230, a novel engineered cytokine, in combination with pembrolizumab: ARTISTRY-1 trial
2020
·
Ira Winer
, Lucy Gilbert
, et al.
·
Journal for ImmunoTherapy of Cancer
·
4
Abstract 591: Efficacy of ALKS 4230, a novel immunotherapeutic agent, in murine syngeneic tumor models alone and in combination with immune checkpoint inhibitors
2017
·
Heather C. Losey
, Jared E. Lopes
, et al.
·
Cancer Research
·
4
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Works count:
45
Citation count:
2,196
H-index:
17
I10-index:
19
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