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Joseph M. Covey

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.
1989 · C Holm, J M Covey, et al. · PubMed · 366
Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.
1989 · J M Covey, C Jaxel, et al. · PubMed · 245
Activated neutrophils induce prolonged DNA damage in neighboring cells
1988 · E. Shacter, E.J. Beecham, et al. · Carcinogenesis · 235
Strategy and planning for chemopreventive drug development: Clinical development plans II
1996 · Gary J. Kelloff, James A. Crowell, et al. · Journal of Cellular Biochemistry · 196
Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD 2 F 1 mice and Fischer 344 rats
2002 · Merrill Egorin, Theodore Lagattuta, et al. · Cancer Chemotherapy and Pharmacology · 175
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts
2004 · Julie L. Eiseman, Jing Lan, et al. · Cancer Chemotherapy and Pharmacology · 154
Increased CDA Expression/Activity in Males Contributes to Decreased Cytidine Analog Half-Life and Likely Contributes to Worse Outcomes with 5-Azacytidine or Decitabine Therapy
2013 · Reda Z. Mahfouz, Ania Jankowska, et al. · Clinical Cancer Research · 135
Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
2001 · Merrill J. Egorin, Eleanor G. Zuhowski, et al. · Cancer Chemotherapy and Pharmacology · 133
DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators
1987 · Yves Pommier, Joseph M. Covey, et al. · Nucleic Acids Research · 133
Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance
2005 · Elizabeth R. Glaze, Amy L. Lambert, et al. · Cancer Chemotherapy and Pharmacology · 115
Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.
1987 · J Markovits, Y Pommier, et al. · PubMed · 109
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
2011 · Donald Lavelle, Kestis Vaitkus, et al. · Blood · 99
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Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine
2005 · Julianne L. Holleran, Robert A. Parise, et al. · Clinical Cancer Research · 96
Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.
1988 · J M Covey, K W Kohn, et al. · PubMed · 74
Inhibition of in Vitro and in Vivo HIV Replication by a Distamycin Analogue That Interferes with Chemokine Receptor Function: A Candidate for Chemotherapeutic and Microbicidal Application
1998 · O. M. Z. Howard, J. J. Oppenheim, et al. · Journal of Medicinal Chemistry · 71
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
1988 · Y Pommier, D Kerrigan, et al. · PubMed · 71
Modulation of Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine) Pharmacokinetics, Metabolism, and Bioavailability in Mice by 3,4,5,6-Tetrahydrouridine
2008 · Jan H. Beumer, Julie L. Eiseman, et al. · Clinical Cancer Research · 66
Chemoresistance to Depsipeptide FK228 [(E)-(1 S,4 S,10 S,21 R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] Is Mediated by Reversible MDR1 Induction in Human Cancer Cell Lines
2005 · Jim J. Xiao, Ying Huang, et al. · Journal of Pharmacology and Experimental Therapeutics · 66
Pharmacokinetics of EF5 [2-(2-nitro-1- H -imidazol-1-yl)- N -(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles
2001 · Koch C., Hahn S., et al. · Cancer Chemotherapy and Pharmacology · 65
DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues.
1990 · L Dusre, S Rajagopalan, et al. · PubMed · 62
DNA damage, cytotoxicity and free radical formation by mitomycin C in human cells
1989 · Lata Dusre, Joseph M. Covey, et al. · Chemico-Biological Interactions · 61
Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice
2006 · Jan H. Beumer, Julie L. Eiseman, et al. · Clinical Cancer Research · 60
Differences in DNA damage produced by incorporation of 5-aza-2'-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells.
1986 · J M Covey, M D'Incalci, et al. · PubMed · 57
Polyglutamate derivatives of folic acid coenzymes and methotrexate
1980 · Joseph M. Covey · Life Sciences · 51
Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry
2011 · U. V. R. Vijaya Saradhi, Sneha V. Gupta, et al. · The AAPS Journal · 50
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Works count: 135
Citation count: 3,981
H-index: 32
I10-index: 64
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