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Sandrine Desrayaud

Cannabinoid Receptor 2 Signaling in Peripheral Immune Cells Modulates Disease Onset and Severity in Mouse Models of Huntington's Disease
2012 · Jill Bouchard, Jennifer Truong, et al. · Journal of Neuroscience · 133
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GABAB Receptor Antagonist-Mediated Antidepressant-Like Behavior Is Serotonin-Dependent
2004 · David A. Slattery, Sandrine Desrayaud, et al. · Journal of Pharmacology and Experimental Therapeutics · 128
Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945
2018 · Nicolau Beckmann, Elisa Giorgetti, et al. · Acta Neuropathologica Communications · 127
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Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
2012 · Heinrich Rueeger, Rainer Lueoend, et al. · Journal of Medicinal Chemistry · 100
Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure
2016 · Marianne Fouché, Michael Schäfer, et al. · ChemMedChem · 72
MPEP, an mGlu5 receptor antagonist, reduces the development of l-DOPA-induced motor complications in de novo parkinsonian monkeys: Biochemical correlates
2012 · Nicolas Morin, Laurent Grégoire, et al. · Neuropharmacology · 68
Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application
2009 · Andreas Lerchner, Rainer Machauer, et al. · Bioorganic & Medicinal Chemistry Letters · 58
AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization
2014 · Ivo Vranesic, Silvio Ofner, et al. · Bioorganic & Medicinal Chemistry · 57
Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine
1997 · Sandrine Desrayaud, Pierrette Guntz, et al. · Life Sciences · 57
Macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors with activity in vivo
2009 · Rainer Machauer, Kurt Laumen, et al. · Bioorganic & Medicinal Chemistry Letters · 53
Hyperdopaminergia and altered locomotor activity in GABAB1‐deficient mice
2006 · Claire‐Marie Vacher, Martin Gassmann, et al. · Journal of Neurochemistry · 48
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors
2024 · Juraj Velcicky, Philipp Janser, et al. · Journal of Medicinal Chemistry · 44
Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2
2013 · Thomas Troxler, Paulette Greenidge, et al. · Bioorganic & Medicinal Chemistry Letters · 43
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
2011 · Heinrich Rueeger, Jean-Michel Rondeau, et al. · Bioorganic & Medicinal Chemistry Letters · 43
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome
2024 · Angela Mackay, Juraj Velcicky, et al. · Journal of Medicinal Chemistry · 42
Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity
2009 · Carsten Spanka, Ralf Glatthar, et al. · Bioorganic & Medicinal Chemistry Letters · 32
The positive allosteric modulator GS39783 enhances GABAB receptor‐mediated inhibition of cyclic AMP formation in rat striatum in vivo
2006 · Tina Gjoni, Sandrine Desrayaud, et al. · Journal of Neurochemistry · 32
Pharmacokinetic Studies around the Mono‐ and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold
2016 · Marianne Fouché, Michael Schäfer, et al. · ChemMedChem · 30
Predicting In Vivo Compound Brain Penetration Using Multi-task Graph Neural Networks
2022 · Seid Hamzic, Richard Lewis, et al. · Journal of Chemical Information and Modeling · 28
Modulation of Oral Bioavailability and Metabolism for Closely Related Cyclic Hexapeptides
2017 · Thomas Vorherr, Ian Lewis, et al. · International Journal of Peptide Research and Therapeutics · 27
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Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides
2013 · Heinrich Rueeger, Rainer Lueoend, et al. · Bioorganic & Medicinal Chemistry Letters · 25
6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists
2011 · David Orain, Silvio Ofner, et al. · Bioorganic & Medicinal Chemistry Letters · 22
MS565: A SPECT Tracer for Evaluating the Brain Penetration of BAF312 (Siponimod)
2015 · Emmanuelle Briard, Bettina Rudolph, et al. · ChemMedChem · 21
DeepCt: Predicting Pharmacokinetic Concentration–Time Curves and Compartmental Models from Chemical Structure Using Deep Learning
2024 · Maximilian Beckers, Dimitar Yonchev, et al. · Molecular Pharmaceutics · 19
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors
2015 · Robin A. Fairhurst, Marc Gerspacher, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Works count: 54
Citation count: 1,472
H-index: 22
I10-index: 34
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