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Mark Frigerio

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
2009 · Sarah E. Golding, Elizabeth Rosenberg, et al. · Molecular Cancer Therapeutics · 395
Bridging Disulfides for Stable and Defined Antibody Drug Conjugates
2014 · George Badescu, Penny Bryant, et al. · Bioconjugate Chemistry · 296
The chemistry and biology of the bryostatin antitumour macrolides
2002 · Karl J. Hale, Marc G. Hummersone, et al. · Natural Product Reports · 181
Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
2021 · Marta Poblocka, Akang Leonard Bassey, et al. · Scientific Reports · 143
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In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab–MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios
2015 · Penny Bryant, Martin Pabst, et al. · Molecular Pharmaceutics · 129
Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase
2007 · Jonathan J. Hollick, Laurent J. M. Rigoreau, et al. · Journal of Medicinal Chemistry · 85
Enantioselective Formal Total Synthesis of the Antitumor Macrolide Bryostatin 7
2006 · Soraya Manaviazar, Mark Frigerio, et al. · Organic Letters · 85
1-Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity
2013 · Céline Cano, Kappusamy Saravanan, et al. · Journal of Medicinal Chemistry · 55
Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates
2017 · Martin Pabst, William McDowell, et al. · Journal of Controlled Release · 48
The Chemical Design and Synthesis of Linkers Used in Antibody Drug Conjugates
2018 · Mark Frigerio, Andrew F. Kyle · Current Topics in Medicinal Chemistry · 46
DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype
2010 · Céline Cano, Olivier R. Barbeau, et al. · Journal of Medicinal Chemistry · 45
On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
2013 · Sara Iachettini, Malcolm FG Stevens, et al. · Journal of Experimental & Clinical Cancer Research · 37
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Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4
2019 · Katherine Griffiths, Uli Binder, et al. · mAbs · 31
A Short Synthetic Pathway to a Fully-Functionalized Southern Hemisphere of the Antitumor Macrolide Bryostatin 1
2001 · Karl J. Hale, Mark Frigerio, et al. · Organic Letters · 23
8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)
2008 · Marine Desage-El Murr, Celine Cano, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance
2022 · Nick Evans, Ruslan Grygorash, et al. · Frontiers in Pharmacology · 21
New, Abridged Pathway to Masamune's “Southern Hemisphere” Intermediate for the Total Synthesis of Bryostatin 7
2003 · Karl J. Hale, Mark Frigerio, et al. · Organic Letters · 21
Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines
2016 · David Cousin, Jihong Zhang, et al. · MedChemComm · 18
Synthesis of a Simplified Bryostatin C-Ring Analogue That Binds to the CRD2 of Human PKC-α and Construction of a Novel BC-Analogue by an Unusual Julia Olefination Process
2003 · Karl J. Hale, Mark Frigerio, et al. · Organic Letters · 17
Synthetic studies on the A83586C and bryostatin antitumor macrolides and the monamycin antibiotics
2000 · K. J. Hale, M. G. Hummersone, et al. · Pure and Applied Chemistry · 16
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A Biosynthetic Proposal for Ring Formation in the Antitumor Agent Halichomycin. Asymmetric Synthesis of the AB-Carbon Backbone of Halichomycin
2002 · Karl J. Hale, Paschalis Dimopoulos, et al. · Organic Letters · 11
Bridged Cysteine Conjugations
2019 · Matthew Bird, Joao Nunes, et al. · Methods in molecular biology · 10
Abstract 1217: Preclinical evaluation of a next-generation, EGFR targeting ADC that promotes regression in KRAS or BRAF mutant tumors
2016 · Lei Huang, Bob Veneziale, et al. · Cancer Research · 8
Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach [abstract]
2008 · K Saravanan, M Albertella, et al. · Newcastle University ePrints (Newcastle Univesity) · 3
Linker Design and Impact on ADC Properties
2021 · M. Frigerio, N. Camper · Royal Society of Chemistry eBooks · 1
Works count: 43
Citation count: 1,748
H-index: 18
I10-index: 22
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