Get started
Author

David Leitsch

Observed names: D. Leitsch, Leitsch, David
ORCID: 0000-0001-9128-4501
Observed ORCID: 0000-0001-9128-4501
OpenAlex ID: A5035452018
A review on metronidazole: an old warhorse in antimicrobial chemotherapy
2017 · David Leitsch · Parasitology · 220
PDF
Trichomonas vaginalis : metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance
2009 · David Leitsch, Daniel Kolarich, et al. · Molecular Microbiology · 173
PDF
RNA chaperone activity of the Sm‐like Hfq protein
2003 · Isabella Moll, David Leitsch, et al. · EMBO Reports · 156
PDF
Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase
2007 · David Leitsch, Daniel Kolarich, et al. · PLoS Biology · 155
PDF
A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia
2013 · Noa Tejman-Yarden, Yukiko Miyamoto, et al. · Antimicrobial Agents and Chemotherapy · 151
PDF
Drug Resistance in the Microaerophilic Parasite Giardia lamblia
2015 · David Leitsch · Current Tropical Medicine Reports · 144
PDF
Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
2011 · D. Leitsch, A. G. Burgess, et al. · Journal of Antimicrobial Chemotherapy · 137
Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis
2020 · Raúl Argüello-García, David Leitsch, et al. · Advances in Parasitology/Advances in parasitology · 110
Recent Advances in the Trichomonas vaginalis Field
2016 · David Leitsch · F1000Research · 88
T richomonas vaginalis flavin reductase 1 and its role in metronidazole resistance
2013 · David Leitsch, Brian D. Janssen, et al. · Molecular Microbiology · 86
PDF
Validation of reference genes for the normalization of RT-qPCR gene expression in Acanthamoeba spp.
2020 · Martina Köhsler, David Leitsch, et al. · Scientific Reports · 73
PDF
Major Role for Cysteine Proteases during the Early Phase of Acanthamoeba castellanii Encystment
2010 · David Leitsch, Martina Köhsler, et al. · Eukaryotic Cell · 72
The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways
2010 · David Leitsch, Daniel Kolarich, et al. · Molecular and Biochemical Parasitology · 66
Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia
2012 · David Leitsch, Sarah Schlosser, et al. · International Journal for Parasitology Drugs and Drug Resistance · 65
PDF
Tritrichomonas foetus isolates from cats and cattle show minor genetic differences in unrelated loci ITS-2 and EF-1α
2011 · Karin Reinmann, Norbert Müller, et al. · Veterinary Parasitology · 62
The N-glycans of Trichomonas vaginalis contain variable core and antennal modifications
2011 · Katharina Paschinger, Alba Hykollari, et al. · Glycobiology · 61
PDF
Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target
2016 · David Leitsch, Joachim Müller, et al. · International Journal for Parasitology Drugs and Drug Resistance · 54
PDF
Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds
2015 · Joachim Müller, Samuel Rout, et al. · International Journal for Parasitology Drugs and Drug Resistance · 54
PDF
Acanthamoeba strains lose their abilities to encyst synchronously upon prolonged axenic culture
2008 · Martina Köhsler, David Leitsch, et al. · Parasitology Research · 54
Down-regulation of flavin reductase and alcohol dehydrogenase-1 (ADH1) in metronidazole-resistant isolates of Trichomonas vaginalis
2012 · David Leitsch, Mirjana Drinić, et al. · Molecular and Biochemical Parasitology · 48
PDF
Redox Pathways as Drug Targets in Microaerophilic Parasites
2018 · David Leitsch, Catrin F. Williams, et al. · Trends in Parasitology · 41
Acanthamoeba castellanii : growth on human cell layers reactivates attenuated properties after prolonged axenic culture
2009 · Martina Koehsler, David Leitsch, et al. · FEMS Microbiology Letters · 39
PDF
Entamoeba histolytica: identification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example
2013 · Sarah Schlosser, David Leitsch, et al. · Biochemical Journal · 34
Drug susceptibility testing in microaerophilic parasites: Cysteine strongly affects the effectivities of metronidazole and auranofin, a novel and promising antimicrobial
2017 · David Leitsch · International Journal for Parasitology Drugs and Drug Resistance · 30
PDF
A study on Nim expression in Bacteroides fragilis
2014 · David Leitsch, József Sóki, et al. · Microbiology · 30
PDF
Works count: 149
Citation count: 2,594
H-index: 28
I10-index: 44
Year
Topic
Type