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René Maltais
Observed names:
Maltais Rene,
Maltais, René,
Maltais, René,
R. MALTAIS,
R. Maltais,
RENÉ MALTAIS,
Rene Maltais,
Rene´ Maltais,
Ren� Maltais
show all 9
Institutions:
Centre hospitalier de l'Université Laval,
Centre de recherche du CHU de Québec-Université Laval
Observed institutions:
Centre hospitalier universitaire de Québec,
University of Kansas Medical Center,
Centre hospitalier de l'Université Laval,
Université Laval,
Quebec Research and Development Centre,
Centre de recherche du CHU de Québec-Université Laval,
CHU de Québec-Université Laval
show all 7
ORCID:
0000-0002-0394-1653
Observed ORCID:
0000-0002-0394-1653
OpenAlex ID:
A5035454604
Steroid sulfatase inhibitors
1999
·
Donald Poirier
, Liviu C Ciobanu
, et al.
·
Expert Opinion on Therapeutic Patents
·
72
Steroid sulfatase inhibitors: A review covering the promising 2000–2010 decade
2011
·
René Maltais
, Donald Poirier
·
Steroids
·
69
Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity
2011
·
Diana Ayan
, Jenny Roy
, et al.
·
The Journal of Steroid Biochemistry and Molecular Biology
·
58
Synthesis and Optimization of a New Family of Type 3 17β-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase Chemistry
2001
·
René Maltais
, Van Luu-The
, et al.
·
Journal of Medicinal Chemistry
·
53
Identification of a 17β‐Hydroxysteroid Dehydrogenase Type 10 Steroidal Inhibitor: A Tool to Investigate the Role of Type 10 in Alzheimer’s Disease and Prostate Cancer
2012
·
Diana Ayan
, René Maltais
, et al.
·
ChemMedChem
·
50
A New Nonestrogenic Steroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer Tumor Growth Induced by Estrone
2012
·
Diana Ayan
, René Maltais
, et al.
·
Molecular Cancer Therapeutics
·
44
Steroids and Combinatorial Chemistry
2004
·
René Maltais
, Martin R. Tremblay
, et al.
·
Journal of Combinatorial Chemistry
·
38
Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-Ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity, and Selectivity
2018
·
Raphaël Dutour
, Jenny Roy
, et al.
·
Journal of Medicinal Chemistry
·
35
Discovery of a Non-Estrogenic Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 from 3-Substituted-16β-( m -carbamoylbenzyl)-estradiol Derivatives
2013
·
René Maltais
, Diana Ayan
, et al.
·
Journal of Medicinal Chemistry
·
33
Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3
2011
·
René Maltais
, Michelle-Audrey Fournier
, et al.
·
Bioorganic & Medicinal Chemistry
·
33
Solid-Phase Synthesis of Hydroxysteroid Derivatives Using the Diethylsilyloxy Linker
2000
·
René Maltais
, Martin R. Tremblay
, et al.
·
Journal of Combinatorial Chemistry
·
32
Design of a Mestranol 2‐N‐Piperazino‐Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF‐7 Breast Cancer Models
2017
·
Martin Perreault
, René Maltais
, et al.
·
ChemMedChem
·
30
PDF
Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging
2021
·
René Maltais
, Jenny Roy
, et al.
·
ACS Medicinal Chemistry Letters
·
29
Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives
2014
·
Diana Ayan
, René Maltais
, et al.
·
Bioorganic & Medicinal Chemistry
·
29
A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells
2010
·
Hajer Jegham
, Jenny Roy
, et al.
·
Investigational New Drugs
·
28
Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of type 3 17β-hydroxysteroid dehydrogenase
2001
·
René Maltais
, Van Luu-The
, et al.
·
Bioorganic & Medicinal Chemistry
·
28
Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide
2018
·
Tang Li
, René Maltais
, et al.
·
The Journal of Physical Chemistry Letters
·
27
Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133
2014
·
René Maltais
, Audrey Delhomme
, et al.
·
Steroids
·
27
Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes
2010
·
Jenny Roy
, René Maltais
, et al.
·
Molecular Diversity
·
26
Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol
2011
·
René Maltais
, Diana Ayan
, et al.
·
ACS Medicinal Chemistry Letters
·
23
PDF
The Sulfamate Functional Group as a New Anchor for Solid-Phase Organic Synthesis
2000
·
Liviu C. Ciobanu
, René Maltais
, et al.
·
Organic Letters
·
23
A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models
2021
·
Donald Poirier
, Jenny Roy
, et al.
·
Cancers
·
22
PDF
Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties
2016
·
Charles Ouellet
, René Maltais
, et al.
·
European Journal of Medicinal Chemistry
·
22
Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10
2018
·
Sophie Boutin
, Jenny Roy
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
21
The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers
2015
·
Lucie Carolle Kenmogne
, Diana Ayan
, et al.
·
PLoS ONE
·
21
PDF
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Works count:
112
Citation count:
1,481
H-index:
22
I10-index:
60
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