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Author

Xiangyi Jiang

Observed name: Jiang, Xiangyi
Institution: Shandong University
Observed institution: Shandong University
ORCID: 0000-0001-6224-2513
Observed ORCID: 0000-0001-6224-2513
OpenAlex ID: A5035542332
Recent applications of click chemistry in drug discovery
2019 · Xiangyi Jiang, Xia Hao, et al. · Expert Opinion on Drug Discovery · 287
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles
2019 · Boshi Huang, Wenmin Chen, et al. · Journal of Medicinal Chemistry · 85
Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
2022 · Zhao Wang, Srinivasulu Cherukupalli, et al. · Journal of Medicinal Chemistry · 75
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Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors
2019 · Xiangyi Jiang, Gaochan Wu, et al. · RSC Advances · 61
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Molecular design opportunities presented by solvent‐exposed regions of target proteins
2019 · Xiangyi Jiang, Ji Yu, et al. · Medicinal Research Reviews · 59
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In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
2020 · Dongwei Kang, Da Feng, et al. · European Journal of Medicinal Chemistry · 37
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties
2020 · Xiangyi Jiang, Boshi Huang, et al. · European Journal of Medicinal Chemistry · 33
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Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
2023 · Xiangyi Jiang, Boshi Huang, et al. · Communications Chemistry · 32
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Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability
2021 · Shujing Xu, Lin Sun, et al. · European Journal of Medicinal Chemistry · 28
Discovery of Novel Dihydrothiopyrano[4,3- d ]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles
2021 · Zhao Wang, Waleed A. Zalloum, et al. · Journal of Medicinal Chemistry · 28
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Development of Novel Dihydrofuro[3,4- d ]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C
2022 · Dongwei Kang, Yanying Sun, et al. · Journal of Medicinal Chemistry · 27
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Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein
2022 · Xiangyi Jiang, Prem Prakash Sharma, et al. · Journal of Medical Virology · 23
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Recent advances in the molecular design and applications of viral RNA-targeting antiviral modalities
2024 · Jiaojiao Dai, Xiangyi Jiang, et al. · Drug Discovery Today · 21
Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility
2020 · Zhao Wang, Dongwei Kang, et al. · European Journal of Medicinal Chemistry · 21
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Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors
2021 · Xujie Zhang, Lin Sun, et al. · European Journal of Medicinal Chemistry · 19
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies
2021 · Boshi Huang, Tiziana Ginex, et al. · Journal of Medicinal Chemistry · 19
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The discovery and design of novel HIV-1 capsid modulators and future perspectives
2022 · Dang Ding, Shujing Xu, et al. · Expert Opinion on Drug Discovery · 18
Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators
2022 · Shuo Wang, Yujie Ren, et al. · Bioorganic Chemistry · 18
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Discovery of potent HIV ‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I
2018 · Dongwei Kang, Zhao Wang, et al. · Chemical Biology & Drug Design · 18
Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening
2023 · Xiangyi Jiang, Jing Li, et al. · RSC Medicinal Chemistry · 16
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Structure–Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs
2020 · Dongwei Kang, Yanying Sun, et al. · ACS Infectious Diseases · 16
Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators
2022 · Xujie Zhang, Lin Sun, et al. · Molecules · 14
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Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles
2023 · Xiangyi Jiang, Boshi Huang, et al. · European Journal of Medicinal Chemistry · 13
Discovery of novel “Dual-site” binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors
2020 · Wei Ai, Jian Zhang, et al. · European Journal of Medicinal Chemistry · 13
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators
2023 · Shujing Xu, Lin Sun, et al. · Journal of Medicinal Chemistry · 12
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Works count: 56
Citation count: 1,100
H-index: 18
I10-index: 27
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