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James A. Fyfe

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine
1977 · Gertrude B. Elion, Phillip A. Furman, et al. · Proceedings of the National Academy of Sciences · 1,600
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.
1986 · P A Furman, J A Fyfe, et al. · Proceedings of the National Academy of Sciences · 1,355
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
1978 · J.A. Fyfe, P.M. Keller, et al. · Journal of Biological Chemistry · 564
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Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity.
1990 · P A Sherman, J A Fyfe · Proceedings of the National Academy of Sciences · 338
Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate
1979 · P A Furman, M H St Clair, et al. · Journal of Virology · 329
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Ribavirin Antagonizes the Effect of Azidothymidine on HIV Replication
1987 · Markus W. Vogt, Kevan L. Hartshorn, et al. · Science · 276
Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus.
1985 · K K Biron, S C Stanat, et al. · Proceedings of the National Academy of Sciences · 241
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
1992 · P A Furman, M Davis, et al. · Antimicrobial Agents and Chemotherapy · 234
Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers
1989 · Paula A. Sherman, James A. Fyfe · Analytical Biochemistry · 213
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U)
1987 · L P Elwell, R Ferone, et al. · Antimicrobial Agents and Chemotherapy · 163
A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.
1986 · K K Biron, J A Fyfe, et al. · Proceedings of the National Academy of Sciences · 157
Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with Herpesvirus genetic information
1980 · Phillip A. Furman, Paul V. McGuirt, et al. · Virology · 148
Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities
1981 · Paul M. Keller, James A. Fyfe, et al. · Biochemical Pharmacology · 147
Differential phosphorylation of (E)-5-(2-bromovinyl)-2'-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus.
1982 · J A Fyfe · Molecular Pharmacology · 128
The selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine
1999 · Gertrude B. Elion, Phillip A. Furman, et al. · Reviews in Medical Virology · 123
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Human immunodeficiency virus type 1 integration protein: DNA sequence requirements for cleaving and joining reactions
1992 · P A Sherman, M L Dickson, et al. · Journal of Virology · 108
Cytoplasmic 5'-nucleotidase catalyzes acyclovir phosphorylation.
1985 · P M Keller, S A McKee, et al. · Journal of Biological Chemistry · 90
Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity
1987 · M N Ellis, P M Keller, et al. · Antimicrobial Agents and Chemotherapy · 83
Kinetic Properties and Inhibition of Orotidine 5′-Phosphate Decarboxylase
1973 · James A. Fyfe, Richard L. Miller, et al. · Journal of Biological Chemistry · 82
Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir
1987 · S Kit, M Sheppard, et al. · Antimicrobial Agents and Chemotherapy · 62
6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus
1991 · D R Averett, G W Koszalka, et al. · Antimicrobial Agents and Chemotherapy · 54
Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses
1995 · D M Lowe, W K Alderton, et al. · Antimicrobial Agents and Chemotherapy · 49
Selection and preliminary characterization of acyclovir-resistant mutants of varicella zoster virus
1982 · Karen K. Biron, James A. Fyfe, et al. · The American Journal of Medicine · 49
Vitamin B12 Biosynthesis
1969 · J A Fyfe, H C Friedmann · Journal of Biological Chemistry · 48
Modifications on the heterocyclic base of acyclovir: syntheses and antiviral properties
1985 · Lilia M. Beauchamp, Bart L. Dolmatch, et al. · Journal of Medicinal Chemistry · 46
Works count: 51
Citation count: 6,988
H-index: 28
I10-index: 36
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