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Jean M. Fletcher

Observed names: Fletcher, J, Fletcher, J.M., Fletcher, Jean, J Fletcher, J M Fletcher, J. Fletcher, J. M. Fletcher, J.M. Fletcher, JM Fletcher, Jean Fletcher, Jean M Fletcher, Jean M. Fletcher, Jean M. Fletcher
Observed institutions: University College Dublin, Trinity College, Trinity College Dublin, The Royal Free Hospital, Vall d'Hebron Institut de Recerca, St. Vincent's University Hospital, Immune Regulation (United Kingdom), HudsonAlpha Institute for Biotechnology, St. James's Hospital, University College London, University of Birmingham, Sapienza University of Rome, Medical Research Council
ORCID: 0000-0002-0670-6659
Observed ORCID: 0000-0002-0670-6659
OpenAlex ID: A5035915158
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
2010 · J M Fletcher, S J Lalor, et al. · Clinical & Experimental Immunology · 972
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CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis
2009 · Jean M Fletcher, Roisin Lonergan, et al. · The Journal of Immunology · 494
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Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
2006 · Milica Vukmanovic-Stejic, Yan Zhang, et al. · Journal of Clinical Investigation · 484
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Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity
2011 · Stephen J Lalor, Lara S Dungan, et al. · The Journal of Immunology · 361
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Cytomegalovirus-Specific CD4+ T Cells in Healthy Carriers Are Continuously Driven to Replicative Exhaustion
2005 · Jean M Fletcher, Milica Vukmanovic-Stejic, et al. · The Journal of Immunology · 299
Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells
2002 · Leonie S. Taams, Milica Vukmanovic-Stejic, et al. · European Journal of Immunology · 237
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Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy
2017 · Barry Moran, Cheryl M. Sweeney, et al. · Journal of Investigative Dermatology · 231
Memory T cell homeostasis and senescence during aging
2005 · Arne N Akbar, Jean M Fletcher · Current Opinion in Immunology · 231
The Loss of Telomerase Activity in Highly Differentiated CD8+CD28−CD27− T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation
2007 · Fiona J Plunkett, Ornella Franzese, et al. · The Journal of Immunology · 224
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Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis
2019 · Deborah Cluxton, Andreea Petrasca, et al. · Frontiers in Immunology · 215
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Cytomegalovirus‐Infected Endothelial Cells Recruit Neutrophils by the Secretion of C‐X‐C Chemokines and Transmit Virus by Direct Neutrophil‐Endothelial Cell Contact and during Neutrophil Transendothelial Migration
1998 · Jane E. Grundy, Keirissa M. Lawson, et al. · The Journal of Infectious Diseases · 197
The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?
2021 · Adina N. MacMahon Copas, Sarah F. McComish, et al. · Frontiers in Neurology · 186
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Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells
2017 · Sharee A Basdeo, Deborah Cluxton, et al. · The Journal of Immunology · 162
IL-17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa
2020 · J M Fletcher, B Moran, et al. · Clinical & Experimental Immunology · 161
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Epstein-Barr virus–specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential
2002 · Padraic J. Dunne, Jeffery M. Faint, et al. · Blood · 147
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IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells
2011 · Cheryl M. Sweeney, Roisin Lonergan, et al. · Brain Behavior and Immunity · 137
Attenuating Regulatory T Cell Induction by TLR Agonists through Inhibition of p38 MAPK Signaling in Dendritic Cells Enhances Their Efficacy as Vaccine Adjuvants and Cancer Immunotherapeutics
2008 · Andrew G Jarnicki, Helen Conroy, et al. · The Journal of Immunology · 137
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Hepatitis C Virus-Specific Th17 Cells Are Suppressed by Virus-Induced TGF-β
2008 · Aileen G Rowan, Jean M Fletcher, et al. · The Journal of Immunology · 131
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Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo
2004 · John R. Reed, Milica Vukmanovic-Stejic, et al. · The Journal of Experimental Medicine · 112
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CD141+ myeloid dendritic cells are enriched in healthy human liver
2013 · Aoife Kelly, Ronan Fahey, et al. · Journal of Hepatology · 103
Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis
2022 · Achilleas Floudas, Conor M Smith, et al. · Annals of the Rheumatic Diseases · 93
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Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell–Mediated Suppression in the Context of Autoimmunity
2015 · Sharee A Basdeo, Barry Moran, et al. · The Journal of Immunology · 92
Natural Killer Cell Lysis of Cytomegalovirus (CMV)-Infected Cells Correlates with Virally Induced Changes in Cell Surface Lymphocyte Function-Associated Antigen-3 (LFA-3) Expression and Not with the CMV-Induced Down-Regulation of Cell Surface Class I HLA
1998 · Jean M Fletcher, H Grant Prentice, et al. · The Journal of Immunology · 91
Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset
2024 · Megan M. Hanlon, Conor M. Smith, et al. · Science Advances · 86
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Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis
2018 · U Fearon, M M Hanlon, et al. · Clinical & Experimental Immunology · 85
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Works count: 105
Citation count: 6,811
H-index: 37
I10-index: 57
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