Author

Jayakumar Surendradoss

Observed names: J. Surendradoss, Surendradoss, Jayakumar

Institution: Chinook Therapeutics (United States)

Observed institutions: Centre for Drug Research and Development, University of British Columbia, Chinook Therapeutics (United States)

ORCID: 0000-0002-4777-1756

Observed ORCID: 0000-0002-4777-1756

OpenAlex ID: A5035933863

Role of Oxidative Metabolism in the Effect of Valproic Acid on Markers of Cell Viability, Necrosis, and Oxidative Stress in Sandwich-Cultured Rat Hepatocytes

2010 · Tony K. L. Kiang, Xiao Wei Teng, et al. · Toxicological Sciences · 57

Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity

2011 · Tony K.L. Kiang, Xiao Wei Teng, et al. · Toxicology and Applied Pharmacology · 55

Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes

2012 · Jayakumar Surendradoss, Thomas K.H. Chang, et al. · Toxicology and Applied Pharmacology · 25

Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria

2021 · Jinyue Ding, Rajesh Gumpena, et al. · ACS Medicinal Chemistry Letters · 23

Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood–Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases

2018 · Ronan Gealageas, Alice Devineau, et al. · Journal of Medicinal Chemistry · 21

Pos-378 Selective Eta Antagonist Atrasentan, Rapidly Reduces Albuminuria and Downregulates Intra-renal Pro-inflammatory and Pro-fibrotic Transcriptional Networks in the Gddy Mouse Model of Spontaneous Iga Nephropathy

2021 · A. KING, R. Oballa, et al. · Kidney International Reports · 11

Evaluation of In Situ Generated Valproyl 1-O-β-Acyl Glucuronide in Valproic Acid Toxicity in Sandwich-Cultured Rat Hepatocytes

2014 · Jayakumar Surendradoss, Thomas K.H. Chang, et al. · Drug Metabolism and Disposition · 10

Drug Metabolism: Detoxification and Xenobiotic Biotransformation

2022 · Jayakumar Surendradoss, Alice Varghese, et al. · Apple Academic Press eBooks · 8

Characterization of CHK-336, A First-in-Class, Liver-Targeted, Small-Molecule Lactate Dehydrogenase Inhibitor for Hyperoxaluria Treatment

2025 · Jennifer H. Cox, Marc-Olivier Boily, et al. · Journal of the American Society of Nephrology · 6

A rapid and sensitive assay to quantify valproyl 1-O-acyl glucuronide in supernatants of sandwich-cultured rat hepatocytes using ultra-high performance liquid chromatography–tandem mass spectrometry

2013 · Jayakumar Surendradoss, András Szeitz, et al. · Journal of Chromatography B · 4

Effects of Atrasentan on Kidney Gene Transcription, Mesangial Cell Proliferation, and Proteinuria in IgA Nephropathy

2025 · Jay J. Kuo, Joyce Wu, et al. · Kidney360 · 2

Discovery of CHK-336: A First-in-Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxaluria

2020 · Jennifer H. Cox, Marc-Olivier Boily, et al. · Journal of the American Society of Nephrology · 1

Preclinical Efficacy of CHK-336: A First in Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxalurias

2022 · Jennifer H. Cox, Marc-Olivier Boily, et al. · Journal of the American Society of Nephrology

Pos-442 Discovery of Chk-336: a First-in-class, Liver-targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxaluria

2021 · J. COX, M.O. Boily, et al. · Kidney International Reports

P134 - Evaluation of CRISPR-CAS9 and CRISPR-CAS13 in modulating drug metabolizing enzymes

2020 · Lisa Chen, Jiabin Qiu, et al. · Drug Metabolism and Pharmacokinetics

The combined application of long term hepatic co-culture and RNA interference for reaction phenotyping: lessons learned

2019 · Anthony Borel, Uma Fogueri, et al. · Drug Metabolism and Pharmacokinetics

Valproic acid biotransformation and toxicity in sandwich-cultured rat hepatocytes

2014 · Surendradoss, Jayakumar · cIRcle (University of British Columbia)

Evaluating In Situ (E)‐2,4‐Diene‐Valproic Acid in the Toxicity of Valproic Acid and (E)‐2‐Ene‐Valproic Acid in Sandwich‐Cultured Rat Hepatocytes

2012 · Jayakumar Surendradoss, Thomas K. H. Chang, et al. · The FASEB Journal

Works count: 18

Citation count: 223

H-index: 8

I10-index: 7