Get started
Author

Richard J Vickers

Observed names: R. J. Vickers, R. Vickers, Richard J. Vickers, Richard Vickers, Vickers, R.J.
ORCID: 0000-0001-9937-6953
Observed ORCID: 0000-0001-9937-6953
OpenAlex ID: A5036118804
Utilizing graph machine learning within drug discovery and development
2021 · Thomas Gaudelet, Ben Day, et al. · Briefings in Bioinformatics · 355
PDF
Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study
2017 · Richard J Vickers, Glenn S Tillotson, et al. · The Lancet Infectious Diseases · 127
PDF
An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases
2003 · Edward W Brooke, Stephen G Davies, et al. · Bioorganic & Medicinal Chemistry · 85
Discovery of 2-Arylbenzoxazoles as Upregulators of Utrophin Production for the Treatment of Duchenne Muscular Dystrophy
2011 · Daniel R. Chancellor, Kay E. Davies, et al. · Journal of Medicinal Chemistry · 81
Asymmetric synthesis and applications of β-amino Weinreb amides: asymmetric synthesis of (S)-coniine
2004 · Anthony J. Burke, Stephen G. Davies, et al. · Organic & Biomolecular Chemistry · 69
Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs)
2003 · Edward W. Brooke, Stephen G. Davies, et al. · Bioorganic & Medicinal Chemistry Letters · 67
Impact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969), a novel treatment for C. difficile infection
2016 · Eugénie Bassères, Bradley T. Endres, et al. · Journal of Antimicrobial Chemotherapy · 59
PDF
Enhanced preservation of the human intestinal microbiota by ridinilazole, a novel Clostridium difficile-targeting antibacterial, compared to vancomycin
2018 · Cheleste M. Thorpe, Anne V. Kane, et al. · PLoS ONE · 56
PDF
Ridinilazole: a novel therapy for Clostridium difficile infection
2016 · Richard J. Vickers, Glenn Tillotson, et al. · International Journal of Antimicrobial Agents · 54
PDF
Bioorganic & Medicinal Chemistry 22 (2014) 6965–6979
2014 · J. Oluoch Odingo, Theresa O’Malley, et al. · 51
Automated Large-Scale Culture and Medium-Throughput Chemical Screen for Modulators of Proliferation and Viability of Human Induced Pluripotent Stem Cell–Derived Neuroepithelial-like Stem Cells
2012 · Donna McLaren, Thorsten Gorba, et al. · SLAS DISCOVERY · 47
PDF
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars
2010 · Isaac M. Westwood, Sanjib Bhakta, et al. · Protein & Cell · 47
PDF
A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections
2015 · Richard Vickers, Neil Robinson, et al. · BMC Infectious Diseases · 44
PDF
In vitro susceptibility of Clostridium difficile to SMT19969 and comparators, as well as the killing kinetics and post-antibiotic effects of SMT19969 and comparators against C. difficile
2015 · D. Corbett, A. Wise, et al. · Journal of Antimicrobial Chemotherapy · 43
PDF
SMT19969 as a treatment for Clostridium difficile infection: an assessment of antimicrobial activity using conventional susceptibility testing and an in vitro gut model
2014 · S. D. Baines, G. S. Crowther, et al. · Journal of Antimicrobial Chemotherapy · 42
PDF
Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile infection, enhances preservation of microbiota-dependent bile acids
2020 · Xi Qian, Karin Yanagi, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 40
Chirally templated boronic acid Mannich reaction in the synthesis of optically active α-amino acids
2000 · Gordon S. Currie, Michael G. B. Drew, et al. · Journal of the Chemical Society Perkin Transactions 1 · 38
SMT19969 for Clostridium difficile infection (CDI): in vivo efficacy compared with fidaxomicin and vancomycin in the hamster model of CDI
2015 · Abdul Sattar, Pia Thommes, et al. · Journal of Antimicrobial Chemotherapy · 35
PDF
Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents
2014 · Joshua Odingo, Theresa O’Malley, et al. · Bioorganic & Medicinal Chemistry · 33
PDF
In Vivo Assessment of SMT19969 in a Hamster Model of Clostridium difficile Infection
2014 · William Weiss, Mark Pulse, et al. · Antimicrobial Agents and Chemotherapy · 33
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnership
2015 · John Mann, Peter W. Taylor, et al. · MedChemComm · 30
PDF
Asymmetric synthesis of substituted 1-aminocyclopropane-1-carboxylic acids via diketopiperazine methodology
2003 · Elena Buñuel, Steven D. Bull, et al. · Organic & Biomolecular Chemistry · 30
Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators
2015 · Jane Freeman, Jonathan Vernon, et al. · Antimicrobial Agents and Chemotherapy · 29
PDF
Imaging-based chemical screens using normal and glioma-derived neural stem cells
2010 · Davide Danovi, Anna Falk, et al. · Biochemical Society Transactions · 28
Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates
2007 · Stephen G. Davies, A. Christopher Garner, et al. · Organic & Biomolecular Chemistry · 28
Works count: 50
Citation count: 1,695
H-index: 26
I10-index: 32
Year
Topic
Type